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1.
The Lancet Regional Health - Europe ; : 100249, 2021.
Article | ScienceDirect | ID: covidwho-1472087

Résumé

Summary Background The effectiveness of heterologous prime-boost Coronavirus disease 2019 (Covid-19) vaccination is currently unknown. Methods From individuals vaccinated with two doses against Covid-19 in Sweden until July 5, 2021 (N=3,445,061), we formed a study cohort including 94,569 individuals that had received heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, 16,402 individuals that received heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination, and 430,100 individuals that received homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 prime-boost vaccination. In addition, 180,716 individuals were selected who were unvaccinated at the date of vaccination in the corresponding case. Unvaccinated individuals were censored at first dose of any vaccine. Baseline was the date of the second dose of any vaccine, with the same date in the corresponding unvaccinated individual. The outcome included incident symptomatic Covid-19 infection occurring >14 days after baseline. Findings During a mean follow-up time of 76 (range 1-183) days, symptomatic Covid-19 infection was confirmed in 187 individuals with heterologous vaccine schedules (incidence rate: 2.0/100,000 person-days) and in 306 individuals from the unvaccinated control group (incidence rate: 7.1/100,000 person-days). The adjusted vaccine effectiveness was 67% (95% CI, 59-73, P<0.001) for heterologous ChAdOx1 nCoV-19 / BNT162b2 prime-boost vaccination, and 79% (95% CI, 62-88, P<0.001) for heterologous ChAdOx1 nCoV-19 / mRNA-1273 prime-boost vaccination. When combined and analysed together, the two heterologous vaccine schedules had an effectiveness of 68% (95% CI, 61-74, P<0.001) which was significantly greater (Pinteraction<0.001) than the 50% effectiveness for homologous ChAdOx1 nCoV-19 / ChAdOx1 nCoV-19 (95% CI, 41-58, P<0.001). Interpretation The findings of this study suggest that the use of heterologous ChAdOx1 nCoV-19 and mRNA prime-boost vaccination is an effective alternative to increase population immunity against Covid-19, including against the Delta variant which dominated the confirmed cases during the study period. These findings could have important implications for vaccination strategies and logistics, and consequently in the battle against the Covid-19 pandemic.

2.
Journal of Vascular Surgery ; 74(5):1771-1772, 2021.
Article Dans Anglais | EMBASE | ID: covidwho-1472085
3.
Journal of Virological Methods ; : 114339, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472084

Résumé

The COVID-19 pandemic has highlighted the need for generic reagents and flexible systems in diagnostic testing. Magnetic bead-based nucleic acid extraction protocols using 96-well plates on open liquid handlers are readily amenable to meet this need. Here, one such approach is rigorously optimized to minimize cross-well contamination while maintaining sensitivity.

4.
Journal of Virological Methods ; : 114337, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472083

Résumé

In Emergency Room, Point-of-care antigen testing for SARS-CoV-2 antigen can expedite clinical strategies for patient management. We tested 1,232 consecutive patients during Italian second wave peak using the recent LumiraDx microfluidic assay. This assay showed high concordance (96.9%), sensitivity and specificity compared to molecular testing, being highly valuable.

5.
Journal of Veterinary Behavior ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472082

Résumé

The COVID-19 pandemic imposed a strict state of emergency on Belgrade residents with a curfew and restriction on movement. Therefore, the aim of this study was to determine how the measures introduced as a consequence of this disease in the capital of Serbia affected the duration of walking time of owners and their dogs. The study allowed for sociodemographics of owners, characteristics of their homes and breeds of dog. The research was conducted in the period from March 22 to April 4, 2020. In general, the COVID-19 pandemic restrictions reduced the duration of dog walks and owners’ walking time. Of the 216 adult dog owners, 59% walked their dogs successfully (≥150 min/week) before the state of emergency. The number of owners who walked their dogs for ≥150 min/week decreased to only 44% (N=96) during the state of emergency. The pandemic also decreased the number of owners who achieved total walking times of ≥150 min/week, so only 56% of them were successful in total walking time during the state of emergency (100% were successful before the pandemic, as this was one of inclusion criteria). This difference was statistically significant (P<0.01). A Wilcoxon signed-rank test found significant differences in the total walking time before and during the state of emergency, with regard to characteristics of the owner, home and dog, with strong effect sizes of these differences were seen (P<0.01). McNemar's test showed that female owners, owners aged 45-64 years and owners with high income who were previously successful in walking their dogs (≥150 min/week) were more affected by the pandemic in regard to walking time with dogs (P<0.01). Significant correlations (P<0.01) were observed between: dog breed and walking time before the state of emergency;age and walking time with the dog during the state of emergency and;age and total walking time during the state of emergency. Comparisons between different categories within the same characteristics (owner demographics, home characteristics and dog breed) by Fisher's exact test found significant differences only between younger and older dog owners in total walking time during the state of emergency (P<0.01). Younger owners were significantly more successful in achieving ≥150 min/week total walking time than owners aged 45-64. The COVID-19 pandemic has left some owners jobless and allowed them to spend more time walking dogs. The occurrence of this disease has led to changes in the social structure of households and in the daily habits of household members. These factors have impacted on the length of walking time of owners and their dogs in Belgrade.

6.
Journal of Veterinary Behavior ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472081

Résumé

An international online questionnaire Pets in Lockdown was conducted during the first COVID-19 lockdown during the months of April and May 2020 to assess how pet owners perceived some aspects of their relationship with their pets, including time spent together and how much they enjoyed it, difficulties taking care of their pets, the amount of comfort they obtained from interacting with their pets, and whether they had observed any changes in their pets’ resting time and behaviour. Most pet owners did not describe any changes in the relationship with their pets or in their pets’ behaviour. Horse owners expressed more difficulties taking care of their animals than owners of other species. Approximately 20% of the animals had less time available to rest undisturbed. Of the animals that displayed behavioural changes, remaining closer to the owner was the most frequently described change followed by descriptions of higher arousal and increased negative affective states.

7.
Vaccine: X ; : 100117, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472080

Résumé

Vaccination of the population seems to be an important strategy in halting the COVID-19 pandemic in both local and global society. The aim of this study was to explore Swedish adolescents’ willingness to be vaccinated against COVID-19 and its association with sociodemographic and other possible factors. A survey was distributed in Sweden between 7 July and 8 November 2020. The main qualitative question concerned adolescents’ thoughts on vaccination against COVID-19 and evaluated whether the adolescents would like to be vaccinated when a COVID-19 vaccine is made available. In total, 702 adolescents aged between 15-19 responded to the questionnaire. A convergent parallel mixed-methods design was used. The results showed that nearly one in three adolescents had not decided if they wanted to get a COVID-19 vaccine, i.e. 30.5%: n=214. Of the participants 54.3% (n=381) were willing to be vaccinated. Girls had higher levels of anxiety about the vaccine compared to boys. In addition, high levels of anxiety impacted on the participants’ willingness to be vaccinated. One reason for being undecided about the vaccine was that participants felt they did not know enough about it. Practising social distancing increased willingness to be vaccinated, as reflected in the qualitative results which showed participants wanted to be vaccinated to protect others. The results impart important knowledge to healthcare professionals and contribute to their communication with adolescents about vaccine hesitancy.

8.
Journal of Taibah University Medical Sciences ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472079

Résumé

Objectives In the wake of recent widespread interest in telemedicine during the COVID-19 era, many orthopaedic surgeons may be unfamiliar with clinical examination skills, patients’ safety, data security, and implementation-related concerns in telemedicine. We present a bibliometric analysis and review of the telemedicine-related publications concerning orthopaedics care during the COVID-19 pandemic. Such analysis can help orthopaedic surgeons become acquainted with the recent developments in telemedicine and its usage in regular orthopaedics practice. Methods We systematically searched the database of Thomson Reuters Web of Science for telemedicine-related articles in orthopaedics published during the COVID-19 pandemic. The selected articles were analysed for their source journals, corresponding authors, investigating institutions, countries of the corresponding authors, number of citations, study types, levels of evidence, and qualitative review. Results Fifty-nine articles meeting the inclusion criteria were published in 28 journals. Three hundred forty-two authors contributed to these research papers. The United States (US) contributed the most number of articles to the telemedicine-related orthopaedics research during the COVID-19 era. All articles combined had a total of 383 citations and 66.1% were related to the Economic and Decision-making Analyses of telemedicine implementation. By and large, level IV evidence was predominant in our review. Conclusion Telemedicine can satisfactorily cover a major proportion of patients' visits to outpatient departments, thus limiting hospitals’ physical workload. Telemedicine has a potential future role in emergency orthopaedics and inpatient care through virtual aids. The issues related to patient privacy, data security, medicolegal, and reimbursement-related aspects need to be addressed through precise national or regional guidelines. Lastly, the orthopaedic physical examination is a weak link in telemedicine and needs to be strengthened.

9.
Journal of Stroke and Cerebrovascular Diseases ; : 106179, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472078

Résumé

Objectives: This study aims to evaluate shortening door-to-needle time of intravenous recombinant tissue plasminogen activator of acute ischemic stroke patients by multidisciplinary collaboration and workflow optimization based on our hospital resources. Materials and Methods: We included patients undergoing thrombolysis with intravenous recombinant tissue plasminogen activator from January 1, 2018, to September 30, 2020. Patients were divided into pre- (January 1, 2018, to December 31, 2019) and post-intervention groups (January 1, 2020, to September 31, 2020). We conducted multi-department collaboration and process optimization by implementing 16 different measures in prehospital, in-hospital, and post-acute feedback stages for acute ischemic stroke patients treated with intravenous thrombolysis. A comparison of outcomes between both groups was analyzed. Results: Two hundred and sixty-three patients received intravenous recombinant tissue plasminogen activator in our hospital during the study period, with 128 and 135 patients receiving treatment in the pre-intervention and post-intervention groups, respectively. The median (interquartile range) door-to-needle time decreased significantly from 57.0 (45.3-77.8) minutes to 37.0 (29.0-49.0) minutes. Door-to-needle time was shortened to 32 minutes in the post-intervention period in the 3rd quarter of 2020. The door-to-needle times at the metrics of ≤30 min, ≤45 min, ≤60 min improved considerably, and the DNT>60min metric exhibited a significant reduction. Conclusions: A multidisciplinary collaboration and continuous process optimization can result in overall shortened door-to-needle despite the challenges incurred by the COVID-19 pandemic.

10.
Saudi Pharmaceutical Journal ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472075

Résumé

Poisoning is a major global health concern. Every year, unintentional poisoning contributes to 106,683 deaths globally. In Kuwait, paediatric poisoning cases comprise approximately 50% of total poisoning cases. Despite the extensive importance and the long history of poison control centres (PCCs) and the emphasis of the World Health Organization (WHO) to establish a PCC in Kuwait, no functional PCC exists in Kuwait. Here we reported 82 poisoning cases between July and December 2020, revealing a 100% increase in comparison to the official figures published in 2004 and 2005. No fatalities were reported, and all cases were discharged home within 12 hours of their visit to the casualty. Children aged 2 to <4 years comprised the most reported poisoning cases with approximately 45% of the total. The number of male child poisoning cases was approximately two-fold of female children. The most common poisoning agent was silica gel granules (9%) followed by medicines – reported as paracetamol (7%), diclofenac (7%), multivitamin gummies (7%) and vitamin C (5%). Among other causes of poisoning were ingestion of salbutamol nebulizer solution (4%), oral contraceptives and insecticides (4%). These findings reveal the importance of establishing a functional PCC in Kuwait to minimise the unnecessary visits following ingestion of expired orange juice and henna, that may encounter further contraction of infections, especially with the current state of the COVID-19 pandemic. Moreover, a functional PCC would provide comprehensive data and hence further intervention such as shifting the dosage form of salbutamol from nebulizer solution to metered dose inhaler with a spacer, in addition to increasing public awareness towards minimizing such a dramatic increase in casualty visits because of -suspected poisoning.

11.
Journal of Saudi Chemical Society ; : 101367, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472074

Résumé

The current COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, remains a serious health hazard globally. The SARS-CoV-2 Mpro and spike proteins, as well as the human ACE2 receptor, have previously been reported as good targets for the development of new drug leads to combat COVID-19. Various ligands, including synthetic and plant-derived small molecules, can interact with the aforementioned proteins. In this study, we investigated the interaction of eight phytochemicals, from selected medicinal plants (Aegle marmelos, Azadirachta indica, and Ocimum sanctum) commonly used in Indian traditional medicine, with SARS-CoV-2 Mpro (PDBID: 6LU7), SARS-CoV-2S spike protein (PDB ID: 6M0J) and the human ACE2 receptor (PDB ID: 6M18). All compounds were subjected to density functional theory (DFT) and frontier molecular orbitals (FMO) analysis to determine their geometry, and key electronic and energetic properties. Upon examining the interactions of the phytochemicals with the human ACE2 receptor and the SARS-CoV-2 Mpro, spike protein targets, two compounds (C-5 and C-8) were identified as the best binding ligands. These were further examined in MD simulation studies to determine the stability of the ligand-protein interactions. QSAR, pharmacokinetic and drug-likeness properties studies revealed that C-5 may be the best candidate to serve as a template for the design and development of new drugs to combat COVID-19.

12.
Journal of Retailing and Consumer Services ; 64:102811, 2022.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472073

Résumé

Using the regulatory-focus theory (i.e. promotion- and prevention-focused concepts), the research investigates shoppers' positive/negative coping behaviours and segmentation linked to COVID-19. Supported by an online survey with 213 shoppers conducted after the first national lockdown (March 2020), factor analysis identified a set of four shopping factors meaningful to profile shoppers’ coping behaviours and segmentation. Positive coping is represented by quality-, price- and brand-focused shopping factors, whereas negative coping is represented by store-focused. The resultant three shopper segments are known as the mindful shopper (positive and negative coping), and the indulgent and the optimal shoppers (more positive coping).

13.
Journal of Psychiatric Research ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472071
14.
Journal of Psychiatric Research ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472070

Résumé

The coronavirus (COVID-19) pandemic has brought focus to the effects of anxiety on children. This study aimed to review the existing literature regarding the impact of the pandemic on pediatric anxiety. This review analyzed the existing literature between the open-sourced collection on PubMed inputting “anxiety disorder in children during pandemic” and “pediatric anxiety OR child anxiety AND COVID” and that of the Journal of the American Academy of Child & Adolescent Psychiatry using the keywords “social anxiety AND COVID.” This yielded 149 + 312 (461) entries and 68 articles were selected. Anxiety was found to have a prevalence of 18.9–23.87% in children during the COVID-19 pandemic whereas adolescent populations demonstrated a prevalence of 15.4–39.9%. Female gender was the most studied risk factor and physical activity was the most documented preventative factor. This review supported the notion that the COVID-19 pandemic is a major contributor to anxiety in the pediatric population.

15.
Journal of Policy Modeling ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472069

Résumé

Several scholars have focused on the COVID-19 case studies in Europe and USA, leaving the people in Southeast Asia with little information about the lesson learned from their own case studies. This study aims to analyses case studies through the SEIR model in three Southeast Asia countries including Singapore, Malaysia, and Indonesia. The SEIR model incorporates two type measures including social behavior and lockdowns as well as hospital preparedness. The SEIR model reveals that Malaysia, despite its relatively low testing capacity but with the application of the national lockdown, can slash the coronavirus transmission while Indonesia has still struggled to contain the COVID-19 flow owing to partial lockdowns. Singapore, at one hand, can successfully contain the coronavirus due to the national lockdowns, and the better healthcare system. With this point in mind, it is not surprised that Singapore has very low fatality rates and significantly low cases after lockdowns. Better preparedness, the full lockdowns, and sufficient testing capacity are keys to control the COVID-19 flow, especially if the development of vaccines or distribution of respective vaccines is under progress.

16.
The Journal of Pediatrics ; 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472068
17.
Joule ; 5(10):2687-2714, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472067

Résumé

Summary A potential response to the COVID-19 pandemic in sub-Saharan Africa (SSA) with long-term benefits is to provide electricity for medical equipment in rural health centers and communities. This study identifies a large gap in the electrification of healthcare facilities in SSA, and it shows that decentralized photovoltaic systems can offer a clean, reliable, quick, and cost-effective solution. The cost of providing renewable electricity to each health facility by a stand-alone PV system is analyzed for a given location (incorporating operational costs). The upfront investment cost for providing electricity with PV to >50,000 facilities (mostly primary health posts) currently without electricity is estimated at EUR 484 million. Analysis of the accessibility and population distribution shows that 281 million people could reduce their travel time to healthcare facilities (by an average of 50 min) if all facilities were electrified.

18.
Journal of Orthopaedic Translation ; 31:1-9, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472066

Résumé

Background/objective Coronavirus disease 2019 (COVID-19) is a disaster in human medical history and glucocorticoids remain the most promising therapy. Osteonecrosis is a disease caused by reduced intraosseous blood flow to bones in the joints, which will rapidly induce joint destruction. Approximately one-third patients with severe acute respiratory syndrome (SARS) who received high cumulative doses and long treatment durations of glucocorticoids occurred osteonecrosis. Considering the similarity of SARS and COVID-19 on their pathogen, clinical characteristics, and therapeutic strategies, it is particularly desirable to investigate whether osteonecrosis will become a common sequela among convalescent COVID-19 patients. Methods This multi-strategy study was designed by integrating different research methods, such as meta-analysis, systematic review, and cross-sectional investigations to address above study objectives. At first, two meta-analyses were performed on the osteonecrosis incidence among SARS patients and the clinical data of glucocorticoid exposure among COVID-19 patients. Then, a systematic review of low-dosage glucocorticoid associated osteonecrosis and a cross-sectional investigation of glucocorticoid exposure of COVID-19 patients in Wuhan city of China were also conducted. Moreover, the pathogenesis, diagnosis, prevention, and treatment options for osteonecrosis patients with COVID-19 infection were further presented and discussed. Results Our meta-analysis showed that 32% of SARS patients had developed osteonecrosis after receiving glucocorticoid treatment with high dose, and our system review supported that low level glucocorticoid exposure might also lead to the occurrence of osteonecrosis. Similarly, 40% of COVID-19 patients had undergone glucocorticoid treatment according to our meta-analysis. The cross-sectional investigation in Wuhan city of China found that the average of cumulative glucocorticoid exposure level was 504 

19.
Journal of the Neurological Sciences ; : 120034, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472064
20.
Journal of Neuroimmunology ; : 577755, 2021.
Article Dans Anglais | ScienceDirect | ID: covidwho-1472063

Résumé

Vaccine administration may be involved in the development of some central nervous system demyelinating diseases. The COVID-19 vaccine is being administered to the entire population, but to date, little association between vaccination and the risk of developing multiple sclerosis (MS) has been suggested, and only a few case reports have been published. Here, we present a 40-year-old woman who developed cervical myelitis after receiving the COVID-19 vaccine. Myelitis was considered the initial clinical manifestation of MS. Our case suggests a possible link between the vaccination and the clinical MS attack.

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