In-depth virological assessment of kidney transplant recipients with COVID-19.
Am J Transplant
; 20(11): 3162-3172, 2020 11.
Article
Dans Anglais
| MEDLINE | ID: covidwho-703597
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
See preprint
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread widely, causing coronavirus disease 2019 (COVID-19) and significant mortality. However, data on viral loads and antibody kinetics in immunocompromised populations are lacking. We aimed to determine nasopharyngeal and plasma viral loads via reverse transcription-polymerase chain reaction and SARS-CoV-2 serology via enzyme-linked immunosorbent assay and study their association with severe forms of COVID-19 and death in kidney transplant recipients. In this study, we examined hospitalized kidney transplant recipients with nonsevere (n = 21) and severe (n = 19) COVID-19. SARS-CoV-2 nasopharyngeal and plasma viral load and serological response were evaluated based on outcomes and disease severity. Ten recipients (25%) displayed persistent viral shedding 30 days after symptom onset. The SARS-CoV-2 viral load of the upper respiratory tract was not associated with severe COVID-19, whereas the plasma viral load was associated with COVID-19 severity (P = .010) and mortality (P = .010). All patients harbored antibodies during the second week after symptom onset that persisted for 2 months. We conclude that plasma viral load is associated with COVID-19 morbidity and mortality, whereas nasopharyngeal viral load is not. SARS-CoV-2 shedding is prolonged in kidney transplant recipients and the humoral response to SARS-CoV-2 does not show significant impairment in this series of transplant recipients.
Texte intégral:
Disponible
Collection:
Bases de données internationales
Base de données:
MEDLINE
Sujet Principal:
Transplantation rénale
/
Charge virale
/
Pandémies
/
SARS-CoV-2
/
COVID-19
/
Anticorps antiviraux
Type d'étude:
Études expérimentales
/
Étude observationnelle
/
Étude pronostique
Les sujets:
Covid long
Limites du sujet:
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
/
Adulte d'âge moyen
Pays comme sujet:
Europe
langue:
Anglais
Revue:
Am J Transplant
Thème du journal:
Transplantation
Année:
2020
Type de document:
Article
Pays d'affiliation:
Ajt.16251
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