Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 41
Filter
1.
Rev. esp. med. nucl. (Ed. impr.) ; 30(2): 97-100, mar.-abr. 2011. ilus
Article in Spanish | IBECS | ID: ibc-86205

ABSTRACT

La esplenosis se define como el autotrasplante heterotópico de tejido esplénico como resultado de una rotura del bazo por trauma o cirugía. Es una condición benigna y de hallazgo casual, aunque en ciertas ocasiones las pruebas de imagen puedan orientar a malignidad simulando tumores renales, linfomas abdominales y endometriosis, entre otros. Presentamos el caso de un varón de 42 años al que, tras un estudio por dolor abdominal, se le realiza una resonancia magnética en la que se observan múltiples adenopatías en el abdomen que pueden orientar a un síndrome linfoproliferativo. Como antecedente importante, presenta esplenectomía por trauma abdominal a los 9 años. Tras varios estudios, se decide realizar una gammagrafía con hematíes desnaturalizados marcados con tecnecio-99m que muestra múltiples depósitos patológicos distribuidos por todo el abdomen e, incluso, la pelvis, siendo este hallazgo compatible con esplenosis(AU)


Splenosis is defined as the heterotopic autotransplantation of splenic tissue because of a ruptured spleen due to trauma or surgery. It is a benign and incidental finding, although imaging tests may sometimes orient toward malignancy simulating renal tumors, abdominal lymphomas, endometriosis, among other. We report the case of a 42-year old male in whom a MRI was performed after a study due to abdominal pain. Multiple enlarged lymph nodes were observed in the abdomen, suggestive of lymphoproliferative disease. As an important background, splenectomy was carried out due to abdominal trauma at age 9. After several studies, it was decided to perform a 99mTc-labeled heat-damaged red blood cell scintigraphy that showed multiple pathological deposits distributed throughout the abdomen, and even the pelvis, being consistent with splenosis(AU)


Subject(s)
Humans , Male , Adult , Splenosis , Technetium , Erythrocytes , Magnetic Resonance Imaging/instrumentation , Magnetic Resonance Imaging , Lymphoproliferative Disorders , /methods , Radiography, Thoracic/methods , Splenosis/physiopathology , Abdominal Pain/etiology , Abdominal Pain , Splenectomy/methods , Nuclear Medicine/methods
2.
Rev Esp Med Nucl ; 30(2): 97-100, 2011.
Article in Spanish | MEDLINE | ID: mdl-20570413

ABSTRACT

Splenosis is defined as the heterotopic autotransplantation of splenic tissue because of a ruptured spleen due to trauma or surgery. It is a benign and incidental finding, although imaging tests may sometimes orient toward malignancy simulating renal tumors, abdominal lymphomas, endometriosis, among other. We report the case of a 42-year old male in whom a MRI was performed after a study due to abdominal pain. Multiple enlarged lymph nodes were observed in the abdomen, suggestive of lymphoproliferative disease. As an important background, splenectomy was carried out due to abdominal trauma at age 9. After several studies, it was decided to perform a (99m)Tc-labeled heat-damaged red blood cell scintigraphy that showed multiple pathological deposits distributed throughout the abdomen, and even the pelvis, being consistent with splenosis.


Subject(s)
Splenosis/diagnostic imaging , Abdominal Injuries/surgery , Abdominal Pain/etiology , Adult , Bromhexine , Cholestasis/diagnosis , Diagnosis, Differential , Erythrocytes , Humans , Incidental Findings , Lymphatic Metastasis , Lymphoproliferative Disorders/diagnosis , Magnetic Resonance Imaging , Male , Postoperative Complications/diagnostic imaging , Postoperative Complications/etiology , Postoperative Complications/pathology , Radiography , Radionuclide Imaging , Radiopharmaceuticals , Spleen/injuries , Spleen/surgery , Splenectomy , Splenosis/epidemiology , Splenosis/etiology , Splenosis/pathology , Technetium , Time Factors
3.
Rev. esp. med. nucl. (Ed. impr.) ; 29(1): 25-28, ene.-feb. 2010. ilus
Article in Spanish | IBECS | ID: ibc-75516

ABSTRACT

IntroducciónEl tumor carcinoide es una rara neoplasia de origen neuroendocrino con localizaciones diversas, siendo las más frecuentes en la edad pediátrica el apéndice y el pulmón. La gammagrafía con 111In-DTPA-d-Phe1-octreótido ha supuesto un considerable avance en el diagnóstico de extensión de pacientes con tumor carcinoide. Presentamos tres pacientes pediátricos con carcinoide bronquial (CB) explorados con gammagrafía con análogos de la somatostatina (GRSS).La primera paciente (9 años) fue estudiada mediante GRSS tras cirugía por tumoración carcinoide en el lóbulo inferior derecho (LID), que objetivó resto tumoral (más evidente en el estudio tomográfico). Nuevos estudios de control con GRSS demostraron el aumento de tamaño del resto tumoral, la existencia de metástasis óseas, hepáticas y otro foco pulmonar de forma más precoz que las otras técnicas de imagen realizadas.La segunda paciente (10 años) acudió por tumoración endobronquial en el lóbulo inferior izquierdo (LII) junto con atelectasia del lóbulo superior izquierdo y enfisema del LII. Las técnicas de imagen radiológicas planteaban el diagnóstico diferencial entre tumor carcinoide endobronquial o granulomas de células plasmáticas o a cuerpo extraño. La GRSS mostró un depósito anormal de actividad en el hemitórax izquierdo compatible con tumoración carcinoide. No se visualizaron otras áreas sugestivas de metástasis. Tras la cirugía (resección endobronquial), los nuevos controles con GRSS mostraron ausencia de enfermedad.El tercer paciente (12 años) acudió tras lobectomía (lóbulo superior derecho) por CB. La GRSS no mostró áreas anormales de actividad. En un control posterior (3 meses) se visualizó un depósito de actividad en el tercio medio del hemitórax derecho, tras lo que se realizó lobectomía (LID y lóbulo medio), que objetivó pequeños restos de carcinoide neuroendocrino. Los controles posteriores fueron negativos...(AU)


IntroductionCarcinoid tumor is a rare neuroendocrine neoplasm with different locations, the most frequent ones during the pediatric age being the appendix and lung. Scintigraphy with 111In-DTPA-d-Phe1-octreotide has led to an importance advance in the diagnosis of extension in carcinoid tumor patients. We present three pediatric patients with bronchial carcinoid studied with somatostatin analogue scintigraphy (SSRS).Clinical casesThe first patient (9 years) was studied using the SSRS after surgery due to carcinoid tumor in the right lower lobe in which tumor remains was observed (this being clearer in the tomography study).The second patient (10 years) presented due to endobronchial tumor in the left lower lobe together with atelectasis of the LUL and emphysema of the LLL. Radiology imaging techniques suggested the differential diagnosis between the endobronchial carcinoid tumor or plasma cells or foreign body gramuloma. The SSRS showed an abnormal deposit of activity in the left hemithorax consisted with carcinoid tumor. No other areas suggesting metastasis were observed. After the surgery (endobronchial resection), new controls with SSRS showed absence of disease.The third patient (12 years) came after a lobectomy (RUL) due to bronchial carcinoid. The SSRS did not show any abnormal areas of activity. In the subsequent control (3 months), a deposit of activity was observed in the middle third of the right hemithorax, after which a lobectomy was performed (RLL and ML) that showed small remains of neuroendocrine carcinoid. Subsequent controls were negative.ConclusionThe SSRS has demonstrated great utility in the diagnosis, follow-up and staging of pediatric patients, carriers of neuroendocrine carcinoid tumors(AU)


Subject(s)
Humans , Male , Female , Child , Somatostatin , Carcinoma/complications , Carcinoma/diagnosis , Carcinoma, Bronchogenic/diagnosis , Ultrasonography/methods , Pneumonectomy/methods , Neoplasm Metastasis/pathology , Diagnosis, Differential , Prognosis
4.
Rev Esp Med Nucl ; 29(1): 25-8, 2010.
Article in Spanish | MEDLINE | ID: mdl-19819594

ABSTRACT

INTRODUCTION: Carcinoid tumor is a rare neuroendocrine neoplasm with different locations, the most frequent ones during the pediatric age being the appendix and lung. Scintigraphy with (111)In-DTPA-d-Phe(1)-octreotide has led to an importance advance in the diagnosis of extension in carcinoid tumor patients. We present three pediatric patients with bronchial carcinoid studied with somatostatin analogue scintigraphy (SSRS). CLINICAL CASES: The first patient (9 years) was studied using the SSRS after surgery due to carcinoid tumor in the right lower lobe in which tumor remains was observed (this being clearer in the tomography study). The second patient (10 years) presented due to endobronchial tumor in the left lower lobe together with atelectasis of the LUL and emphysema of the LLL. Radiology imaging techniques suggested the differential diagnosis between the endobronchial carcinoid tumor or plasma cells or foreign body gramuloma. The SSRS showed an abnormal deposit of activity in the left hemithorax consisted with carcinoid tumor. No other areas suggesting metastasis were observed. After the surgery (endobronchial resection), new controls with SSRS showed absence of disease. The third patient (12 years) came after a lobectomy (RUL) due to bronchial carcinoid. The SSRS did not show any abnormal areas of activity. In the subsequent control (3 months), a deposit of activity was observed in the middle third of the right hemithorax, after which a lobectomy was performed (RLL and ML) that showed small remains of neuroendocrine carcinoid. Subsequent controls were negative. CONCLUSION: The SSRS has demonstrated great utility in the diagnosis, follow-up and staging of pediatric patients, carriers of neuroendocrine carcinoid tumors.


Subject(s)
Biomarkers, Tumor/analysis , Bronchial Neoplasms/diagnostic imaging , Carcinoid Tumor/diagnostic imaging , Lung Neoplasms/diagnostic imaging , Neoplasm Proteins/analysis , Receptors, Somatostatin/analysis , Bronchial Neoplasms/chemistry , Bronchial Neoplasms/surgery , Carcinoid Tumor/chemistry , Carcinoid Tumor/surgery , Child , Diagnosis, Differential , Female , Humans , Indium Radioisotopes , Lung Neoplasms/chemistry , Lung Neoplasms/surgery , Male , Octreotide/analogs & derivatives , Pneumonectomy , Postoperative Care , Postoperative Complications/etiology , Pulmonary Atelectasis/etiology , Pulmonary Emphysema/etiology , Radionuclide Imaging , Radiopharmaceuticals , Reoperation
5.
Rev Esp Med Nucl ; 28(5): 242-5, 2009.
Article in Spanish | MEDLINE | ID: mdl-19922841

ABSTRACT

We present a clinical case of a 54-year-old woman that was admitted in our hospital with the diagnosis of fever of unknown origin. All the laboratory tests and imaging techniques did not manage to establish the fever's aetiology until a (67)Ga-citrate scan was performed and kidney uptake was observed, which lead to the clinical suspicion of drug-induced interstitial nephritis. The renal biopsy confirmed the diagnosis. This finding allowed corticoid therapy and cure.


Subject(s)
Citrates , Fever of Unknown Origin/etiology , Gallium , Nephritis, Interstitial/complications , Nephritis, Interstitial/diagnostic imaging , Radiopharmaceuticals , Female , Humans , Middle Aged , Radionuclide Imaging
6.
Rev. esp. med. nucl. (Ed. impr.) ; 28(5): 242-245, sept.-oct. 2009.
Article in Spanish | IBECS | ID: ibc-73594

ABSTRACT

Exponemos el caso de una paciente mujer de 54 años que ingresó en nuestro hospital para estudio de fiebre de origen desconocido.Todas las pruebas de laboratorio y de imagen no lograron establecer la causa de la fiebre y, al realizar una gammagrafía con 67Ga-citrato, se objetivó captación patológica en los riñones, lo que llevó a la sospecha clínica de nefritis intersticial inducida por medicamentos. La biopsia renal confirmó el diagnóstico. Este hallazgo permitió el tratamiento con corticoides y la curación de la enferma(AU)


We present a clinical case of a 54-year-old woman that was admitted in our hospital with the diagnosis of fever of unknown origin.All the laboratory tests and imaging techniques did not manage to establish the fever's aetiology until a 67Ga-citrate scan was performed and kidney uptake was observed, which lead to the clinical suspicion of drug-induced interstitial nephritis. The renal biopsy confirmed the diagnosis. This finding allowed corticoid therapy and cure(AU)


Subject(s)
Humans , Female , Middle Aged , Nephritis, Interstitial , Fever of Unknown Origin/complications , Fever of Unknown Origin/etiology , Biopsy/methods , Nephritis, Interstitial/complications , Nephritis, Interstitial/diagnosis , Nephritis, Interstitial , Fever of Unknown Origin
9.
Rev Esp Med Nucl ; 25(3): 166-71, 2006.
Article in Spanish | MEDLINE | ID: mdl-16762270

ABSTRACT

OBJECTIVE: Relative renal function (RRF) quantification based on dimercaptosuccinic acid (DMSA) uptake is an established method for determining differential renal function. An abnormal kidney size may lead to an alteration in its RRF value, although it has no dysfunction. Therefore, it is useful to correct RRF values taking into account relative renal volumes, thus obtaining the normalized relative renal function (NRRF). The feasibility of the method used for volume correction, differences with respect to usual quantification and different normality intervals were studied. MATERIAL AND METHODS: A total of 187 DMSA renal scintigraphies (130 children and 57 adults) were studied. RRF was quantified and volume corrected to obtain NRRF. Patients were classified as normal or pathological using various normality intervals for NRRF. A second classification was performed depending on how the diagnostic changed after volume correction. RESULTS: An increase of pathological diagnosis was observed after volume correction, mainly in children. Using an intermediate estimation for the normality interval, 53% of the initially pathological diagnosis for children may be caused simply by different renal volumes. CONCLUSIONS: NRRF provides complementary information to RRF and helps to distinguish between a smaller kidney and a really hypofunctioning one in cases with abnormal RRF.


Subject(s)
Kidney Function Tests/methods , Kidney/physiopathology , Succimer , Adolescent , Adult , Age Factors , Aged , Aged, 80 and over , Algorithms , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Kidney/pathology , Kidney Diseases/diagnosis , Kidney Diseases/pathology , Kidney Diseases/physiopathology , Male , Middle Aged , Organ Size , Reference Values , Sex Factors , Succimer/pharmacokinetics
10.
Rev. esp. med. nucl. (Ed. impr.) ; 25(3): 166-171, mayo 2006. ilus, tab, graf
Article in Es | IBECS | ID: ibc-048039

ABSTRACT

Objetivo. La cuantificación de la función renal relativa (FRR) basada en la incorporación de ácido dimercaptosuccínico (DMSA) es un método establecido para la determinación del nivel de funcionamiento renal. Un tamaño anormal del riñón puede producir una alteración en el valor de su FRR, aunque no tenga disfunción alguna. Por tanto, resulta de utilidad corregir por volumen renal relativo los valores de la FRR, obteniendo así la función renal relativa normalizada (FRRN). En este trabajo se estudiará la viabilidad del método utilizado para la corrección por volumen, las diferencias respecto a la cuantificación habitual, y la influencia del margen de normalidad a aplicar. Material y métodos. Se estudiaron las gammagrafías renales con 99mTc-DMSA de 187 pacientes, 130 infantiles y 57 adultos. Se cuantificó la FRR y se corrigió por volumen para evaluar la FRRN. Se clasificaron los pacientes en normales o patológicos estableciendo varios márgenes de normalidad para la FRRN. Se realizó una segunda clasificación de los casos según cómo cambió su valoración al corregir por volumen. Resultados. Se observó un aumento de los diagnósticos patológicos al corregir por volumen, sobre todo en niños. Para el margen de normalidad aceptado se observó que del total de casos infantiles diagnosticados como patológicos inicialmente, el 53 % puede ser debido simplemente a una diferencia de volumen renal. Conclusiones. La FRRN proporciona una información complementaria a la FRR y ayuda a distinguir entre un riñón de menor tamaño y uno realmente hipocaptante en el caso de que la FRR resulte fuera de la normalidad


Objective. Relative renal function (RRF) quantification based on dimercaptosuccinic acid (DMSA) uptake is an established method for determining differential renal function. An abnormal kidney size may lead to an alteration in its RRF value, although it has no dysfunction. Therefore, it is useful to correct RRF values taking into account relative renal volumes, thus obtaining the normalized relative renal function (NRRF). The feasibility of the method used for volume correction, differences with respect to usual quantification and different normality intervals were studied. Material and methods. A total of 187 DMSA renal scintigraphies (130 children and 57 adults) were studied. RRF was quantified and volume corrected to obtain NRRF. Patients were classified as normal or pathological using various normality intervals for NRRF. A second classification was performed depending on how the diagnostic changed after volume correction. Results. An increase of pathological diagnosis was observed after volume correction, mainly in children. Using an intermediate estimation for the normality interval, 53 % of the initially pathological diagnosis for children may be caused simply by different renal volumes. Conclusions. NRRF provides complementary information to RRF and helps to distinguish between a smaller kidney and a really hypofunctioning one in cases with abnormal RRF


Subject(s)
Infant , Child , Adult , Aged , Adolescent , Middle Aged , Humans , Kidney/physiopathology , Succimer , Kidney Function Tests/methods , Age Factors , Algorithms , Kidney/pathology , Kidney Diseases/pathology , Kidney Diseases/physiopathology , Reference Values , Sex Factors , Succimer/pharmacokinetics
11.
Rev Esp Med Nucl ; 21(6): 426-32, 2002.
Article in Spanish | MEDLINE | ID: mdl-12425890

ABSTRACT

This work tries to provide the clinicians an objective tool that can contribute to the assessment of the results of radioisotopic synoviorthesis (RS). This study aims to assess the value of the quantification of bone scintigraphy in blood pool and late phase of the affected joints treated with 90Y silicate, in order to observe the clinical improvement experienced by most of these patients. A total of 69 bone scintigraphies (BS) in blood pool and late phase have been quantified. They belonged to 23 patients who were treated with RS with 90Y. The first scintigraphy study was performed before the treatment, the second and the third ones were performed 2 and 6 months after treatment. In each BS we quantified the index: counts per pixel of healthy / affected joint. We also have calculated the fraction in the late phase: counts per pixel of healthy bone / counts per pixel of affected and healthy joint. For the comparative statistical analysis of the results we used the Student's t test. We considered statistical significance when p < 0.05. All the patients presented clinical improvement. If we compare the index obtained in BS 2 months after treatment and pre-treatment we find statistical significance (p < 0.05) in the increase of index in the anterior view and late phase. If we compare the index obtained in BS 6 month after treatment and pre-treatment, we find a statistically significant increase in the anterior (p < 0.01) and posterior (p < 0.05) view of the blood pool phase and the anterior view of late phase (p < 0.01). The fraction counts per pixel of healthy bone / counts per pixel of affected and healthy joint did not present a significant increase in any BS control (2 and 6 months). We recommend quantification using the index (counts per pixel healthy / affected joint ) proposed in this work, because it is easy to perform, cheap and reliable in the follow-up of patients treated with RS.


Subject(s)
Bone and Bones/diagnostic imaging , Joint Diseases/radiotherapy , Joints/diagnostic imaging , Radiopharmaceuticals/therapeutic use , Silicates/therapeutic use , Yttrium Radioisotopes/therapeutic use , Yttrium/therapeutic use , Adolescent , Adult , Aged , Arthritis, Reactive/complications , Arthritis, Rheumatoid/radiotherapy , Chondromatosis, Synovial/radiotherapy , Female , Follow-Up Studies , Hemarthrosis/etiology , Hemarthrosis/radiotherapy , Hemophilia A/complications , Humans , Joint Diseases/diagnostic imaging , Male , Middle Aged , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Synovial Membrane/blood supply , Synovial Membrane/diagnostic imaging , Synovitis, Pigmented Villonodular/radiotherapy , Treatment Outcome , Yttrium Radioisotopes/pharmacokinetics
12.
Rev. esp. med. nucl. (Ed. impr.) ; 21(6): 426-432, nov. 2002.
Article in Es | IBECS | ID: ibc-17460

ABSTRACT

Este trabajo intenta aportar una herramienta objetiva que pueda contribuir a la valoración del resultado de la sinoviortesis radioisotópicas (SR). El objetivo de este estudio es comprobar el valor de la cuantificación de la gammagrafía ósea en fase precoz y tardía de las articulaciones sometidas a SR con 90Y silicato, con el fin de objetivar la mejoría clínica que experimentan la mayoría de estos pacientes. Se han cuantificado 69 gammagrafías óseas (GO) en fase precoz y tardía pertenecientes a 23 pacientes a los que se les practicó SR con 90Y. El primer estudio gammagráfico se realizó previo al tratamiento, el segundo y tercer estudio se realizaron a los dos y seis meses. En cada GO cuantificamos el índice: cuentas por píxel de la articulación sana / patológica. También calculamos, en la fase tardía, el cociente cuentas por píxel del hueso sano / cuentas por píxel de la articulación patológica y sana. Para el análisis estadístico comparativo de los resultados de la cuantificación utilizamos el test de la t de Student para datos apareados. El nivel de significación estadística se consideró a partir de p < 0,05. Todos los pacientes experimentaron una mejoría clínica. Si comparamos los índices obtenidos en las GO dos meses posttratamiento y pre-tratamiento, encontramos significación estadística (p < 0,05) en el aumento de los índices para la proyección anterior y en fase tardía. Si comparamos los índices obtenidos en las GO seis meses post-tratamiento y pretratamiento, encontramos una aumento de los índices estadísticamente significativo en las proyecciones anterior (p < 0,01) y posterior (p < 0,05) de la fase precoz y en la proyección anterior de la fase tardía (p < 0,01). El cociente cuentas por píxel del hueso sano / cuentas por píxel de la articulación patológica y sana no experimentó un incremento significativo en ninguno de los controles (dos y seis meses). Recomendamos el uso del método de cuantificación de los índices (cuentas por píxel articulación sana / patológica) propuesto en este trabajo, por tratarse de un método sencillo de realizar, de bajo coste y fiable en el seguimiento de pacientes sometidos a SR (AU)


Subject(s)
Middle Aged , Adolescent , Adult , Aged , Male , Female , Humans , Synovitis, Pigmented Villonodular , Synovial Membrane , Yttrium Radioisotopes , Chondromatosis, Synovial , Yttrium , Radiopharmaceuticals , Treatment Outcome , Silicates , Bone and Bones , Arthritis, Rheumatoid , Hemophilia A , Joints , Joint Diseases , Follow-Up Studies , Hemarthrosis , Arthritis, Reactive
13.
Rev Esp Med Nucl ; 21(4): 281-5, 2002 Jul.
Article in Spanish | MEDLINE | ID: mdl-12206741

ABSTRACT

We have studied three women (66,72 and 72 years) with Parkinson's disease of 11, 6 and 21 years of evolution and drug-resistant severe depressive episodes treated with electroconvulsive therapy (ECT). We have performed a brain SPECT (99mTc-HMPAO) before and after the ECT. The clinical improvement of the severe depressive episodes were measured using the Hamilton score. The first patient did not experience any clinical improvement (Hamilton score 42 to 42). In this patient the brain SPECT before treatment presented a reduced perfusion in the posterior parietal region, anterior cingulate cortex and medial frontal and parietal cortex. After the treatment, the brain SPECT did not present significant variations. The second patient presented a moderate clinical improvement (Hamilton score 46 to 36) and also presented moderate improvement in the neurological symptoms. The brain SPECT before the treatment showed reduced perfusion in the left temporal cortex and medium-posterior parietal cortex. After the treatment, it also did not reflect significant variations. The third patient experienced a very good response to the ECT sessions (Hamilton score 45 to 10) and also an improvement regarding the neurological symptoms. This patient presented a reduced perfusion in the medium-posterior parietal regions in the brain SPECT performed before the treatment; these regions presented a moderate improvement in the brain SPECT performed after the treatment. The patient who presented a significant neurological and psychiatric improvement also presented an improvement in the perfusion of the decreased areas in the brain SPECT and showed fewer alterations in the baseline brain SPECT compared with the others. The brain SPECT could have a prognostic (and confirmation) role regarding clinical improvement induced by ECT in resistant depression in Parkinson's disease. ECT is an alternative in treatment of severe depressive drug-resistant episodes associated to the Parkinson's disease.


Subject(s)
Brain/diagnostic imaging , Depressive Disorder/diagnostic imaging , Electroconvulsive Therapy , Parkinson Disease/diagnostic imaging , Tomography, Emission-Computed, Single-Photon , Aged , Antidepressive Agents/therapeutic use , Brain/blood supply , Cerebral Cortex/blood supply , Cerebral Cortex/diagnostic imaging , Cerebrovascular Circulation , Depressive Disorder/drug therapy , Depressive Disorder/etiology , Depressive Disorder/therapy , Drug Resistance , Female , Follow-Up Studies , Humans , Parkinson Disease/psychology , Prognosis , Treatment Outcome
14.
Rev. esp. med. nucl. (Ed. impr.) ; 21(4): 281-285, jul. 2002.
Article in Es | IBECS | ID: ibc-17440

ABSTRACT

Hemos estudiado tres mujeres de 62, 72 y 72 años con enfermedad de Parkinson de 11, 6 y 21 años de evolución y episodios depresivos graves fármaco-resistentes, tratados con terapia electro-convulsiva (TEC). La mejoría clínica de la depresión se midió utilizando la escala de Hamilton. Hemos realizado un SPECT cerebral (99mTcHMPAO) antes y después de la realización de la TEC. La primera paciente no experimentó ninguna mejoría clínica estable (puntuación en la escala de Hamilton de 42 a 42). En esta paciente el SPECT cerebral de perfusión antes del tratamiento presentaba disminución de la perfusión en áreas parietales posteriores, córtex cingular anterior y medial, córtex frontal y parietal. Tras el tratamiento el SPECT no sufrió variaciones significativas. La segunda paciente presentó una mejoría clínica moderada (Hamilton de 46 a 36) y en la sintomatología neurológica. El SPECT cerebral previo al tratamiento mostraba perfusión reducida en el córtex temporal izquierdo y parietal medio-posterior. Tras el tratamiento no experimentó cambios significativos. La tercera paciente respondió de manera muy satisfactoria a la TEC (Hamilton de 45 a 10 e importante mejoría de los síntomas neurológicos). Esta paciente presentaba una perfusión disminuida en las regiones parietales medias y posteriores en el estudio previo al tratamiento. Estas regiones presentaron una mejoría moderada en el estudio posterior. La paciente que presentó mejoría neurológica y psiquiátrica significativa, presentó también una mejoría en la perfusión de las áreas más afectadas en el SPECT cerebral previo y además mostraba menos alteraciones en el estudio basal que las otras pacientes. El SPECT cerebral podría tener un papel pronóstico (y de confirmación) respecto a la mejoría clínica inducida por TEC en la depresión resistente en la enfermedad de Parkinson. La TEC es una alternativa en el tratamiento de los episodios depresivos graves fármaco-resistentes asociados a la enfermedad de Parkinson (AU)


Subject(s)
Aged , Female , Humans , Tomography, Emission-Computed, Single-Photon , Electroconvulsive Therapy , Treatment Outcome , Parkinson Disease , Prognosis , Antidepressive Agents , Cerebral Cortex , Cerebrovascular Circulation , Depressive Disorder , Drug Resistance , Follow-Up Studies , Telencephalon
15.
Rev. esp. med. nucl. (Ed. impr.) ; 20(7): 517-524, dic. 2001.
Article in Es | IBECS | ID: ibc-770

ABSTRACT

Determinar la relación de captación de DMSA del riñón izquierdo frente al derecho, es teóricamente uno de los procedimientos cuantitativos más sencillos en medicina nuclear. La cuantificación puede realizarse sobre la proyección posterior, con o sin proyección lateral para la corrección de la profundidad renal. También puede determinarse la media geométrica usando las proyecciones anterior y posterior. El objetivo de este trabajo es investigar si existen diferencias importantes en la cuantificación de la función renal porcentual utilizando la media geométrica y usando la proyección posterior únicamente. Además tratamos de estudiar la influencia de la edad de los pacientes y la patología de base por la que se solicita la gammagrafía renal en estas diferencias. Por último proponemos un protocolo de trabajo donde indicamos los casos en los que aconsejamos la realización de la media geométrica para minimizar los errores posibles cometidos al utilizar únicamente la proyección posterior. Se han estudiado 328 gammagrafías renales con 99mTcDMSA realizadas en nuestro Servicio de Medicina Nuclear en los últimos 6 meses. La diferencia entre la función del riñón derecho en proyección posterior Rd (post) y el riñón derecho utilizando el método de la media geométrica Rd (MG) se calculó en todos los pacientes. Obtuvimos la media y la desviación estándar de las diferencias así como el coeficiente de correlación entre ambos métodos. Se empleó el test de la t de Student para determinar si la media de las diferencias entre ambos métodos difería estadísticamente de cero. Se encontraron diferencias estadísticamente significativas en los pacientes mayores de 9 años así como en los pacientes con malformaciones del tracto genitourinario (AU)


Subject(s)
Middle Aged , Child, Preschool , Child , Adult , Adolescent , Aged , Male , Infant , Female , Humans , Algorithms , Kidney Function Tests , Reproducibility of Results , Confidence Intervals , Radiopharmaceuticals , Age Factors , Kidney Diseases , Kidney , Technetium Tc 99m Dimercaptosuccinic Acid
16.
Rev. esp. med. nucl. (Ed. impr.) ; 20(7): 544-546, dic. 2001.
Article in Es | IBECS | ID: ibc-766

ABSTRACT

El histiocitoma fibroso maligno (HFM) es el tumor maligno de tejidos blandos más común en edades tardías. Se ha descrito que el HFM presenta avidez por el 67 Ga y tan solo un 38 por ciento de estos por el 99mTc-MDP, aunque pocos casos clínicos se han publicado. Presentamos el caso de un varón de 73 años con un HFM que presentó en la gammagrafía con 99mTc-MDP captación más intensa en fase vascular, siendo uno de los pocos casos descritos de HFM primario que no invaden hueso captadores de 99mTcMDP. En el presente trabajo además se revisan algunos de los casos de HFM publicados y las diferentes técnicas utilizadas para su diagnóstico y seguimiento. (AU)


Subject(s)
Aged , Male , Humans , Technetium Tc 99m Medronate , Radiopharmaceuticals , Neoplasm Invasiveness , Arm , Soft Tissue Neoplasms , Histiocytoma, Benign Fibrous
17.
Rev Esp Med Nucl ; 20(7): 517-24, 2001 Dec.
Article in Spanish | MEDLINE | ID: mdl-11709136

ABSTRACT

Determining the relationship of DMSA uptake of the left versus right kidney is theoretically one of the easiest quantitative procedures in nuclear medicine. The quantification can be performed on the posterior view, with or without a lateral view for correction of kidney depth. The geometric mean can also be determined by using both the anterior and the posterior views. This study has aimed to evaluate if there are significant differences in the quantification of the renal function percentage using only the posterior view and the geometric mean. Furthermore, we evaluated to what extent the patient's age and diagnosis influenced these differences. We have proposed a work protocol in which we indicate which cases the geometric mean should be calculated in order to minimize the possible errors occurring when only the posterior view is used.A total of 328 renal scintigraphies with 99mTc-DMSA performed at our Department in the last six months were studied. The mean and standard deviation of the differences as well as the correlation coefficient between both methods were calculated. The difference between the right renal function in posterior view and the right renal function obtained using the geometric mean was calculated for all the patients. The Student's T test was applied to determine whether the differences between both methods were statistically different from zero. Statistical differences were found in patients older than 9 years and in patients with genitourinary malformations.


Subject(s)
Algorithms , Kidney Function Tests , Kidney/diagnostic imaging , Radiopharmaceuticals , Technetium Tc 99m Dimercaptosuccinic Acid , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Confidence Intervals , Female , Humans , Infant , Kidney/abnormalities , Kidney/physiopathology , Kidney Diseases/diagnostic imaging , Kidney Diseases/physiopathology , Male , Middle Aged , Radionuclide Imaging , Reproducibility of Results
18.
Rev Esp Med Nucl ; 20(7): 544-6, 2001 Dec.
Article in Spanish | MEDLINE | ID: mdl-11709140

ABSTRACT

Malignant fibrous histiocytoma (MFH) is the most common soft tissue malignant tumour in late adult life. MFH has been mentioned to have avid uptake of 67Ga citrate, and only 38% is uptake of 99mTc-MDP, although few cases of MFH have been reported. We present the case of a 73 years old male patient with MFH. In the blood pool phase of the bone scintigraphy, MFH was presented as an intense hyperactive lesion. In the late phase the tumor is one of the few MFH described to have avid uptake for 99mTc-MDP. In this work we also review some cases of MFH described and the different techniques used in the diagnosis and follow-up of these tumours.


Subject(s)
Histiocytoma, Benign Fibrous/diagnostic imaging , Radiopharmaceuticals , Soft Tissue Neoplasms/diagnostic imaging , Technetium Tc 99m Medronate , Aged , Arm , Histiocytoma, Benign Fibrous/pathology , Histiocytoma, Benign Fibrous/surgery , Humans , Male , Neoplasm Invasiveness , Radionuclide Imaging , Radiopharmaceuticals/pharmacokinetics , Soft Tissue Neoplasms/pathology , Soft Tissue Neoplasms/surgery , Technetium Tc 99m Medronate/pharmacokinetics
20.
Rev Esp Med Nucl ; 20(6): 462-5, 2001 Oct.
Article in Spanish | MEDLINE | ID: mdl-11578581

ABSTRACT

The case of a 60-year old woman first presented a rapidly growing left cervical mass is presented. The fine needle aspiration-puncture (FNAP) lead to a diagnosis of thyroiditis. Due to the persistence of the symptoms, the FNAP was repeated again but was not conclusive, so that a surgical biopsy was performed. The pathological diagnosis was diffuse large cell primary thyroid lymphoma (PTL). The PTL is a rare entity that accounts for less than 1% of all the Non-Hodgkin's lymphomas. The thyroid scintigraphy showed the existence of a cold nodule in the left thyroid lobule and the 67Ga scan revealed a large abnormal lesion in the mediastinum that extended to the right latero-cervical region. After two chemotherapy courses, the 67Ga scan was normal.


Subject(s)
Gallium Radioisotopes , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Radiopharmaceuticals , Thyroid Gland/diagnostic imaging , Thyroid Neoplasms/diagnostic imaging , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy, Needle , Combined Modality Therapy , Cyclophosphamide/administration & dosage , Diagnostic Errors , Doxorubicin/administration & dosage , Humans , Lymphoma, Large B-Cell, Diffuse/pathology , Lymphoma, Large B-Cell, Diffuse/therapy , Mediastinal Neoplasms/diagnostic imaging , Mediastinal Neoplasms/therapy , Middle Aged , Neoplasm Staging , Prednisone/administration & dosage , Radionuclide Imaging , Radiotherapy, Adjuvant , Remission Induction , Thyroid Gland/pathology , Thyroid Neoplasms/pathology , Thyroid Neoplasms/therapy , Thyroidectomy , Thyroiditis/diagnosis , Vincristine/administration & dosage
SELECTION OF CITATIONS
SEARCH DETAIL
...