Evaluation of maternal and perinatal outcomes in pregnancy with preeclampsia at Aljala Maternity Hospital

Hypertensive disorders of pregnancy (HDP) accounts for 18% of maternal deaths worldwide, with an estimated number of about 62, 000­77, 000 deaths occur each year. The current study aimed to assess maternal and perinatal outcomes of pregnancies complicated by hypertension in Aljala Maternity Hospital. A retrospective, descriptive, case series analysis for four hundred patients was done on the outcome of hypertensive disorder among pregnant women who admitted and were managed at Aljala teaching hospital with preeclampsia during the years 2019 and 2020. Demographic data involving age, parity, gestational week, clinical and laboratory findings were recorded from the medical files. Additionally, delivery route, indications of cesarean section, fetal and maternal complications were determined. The current finding reported high prevalence of perinatal and maternal mortality among pregnant women with preeclampsia. Moreover, other severe maternal and perinatal complications such as Hemolysis Elevated Liver Enzyme Platelet (HELLP) syndrome, placental abruption, eclamptic fits, as well as low birth weight were also commonly reported. The current study showed early onset of preeclampsia was associated with increased risk of developing adverse maternal-fetal/neonatal outcomes compared to lateonset after 36 weeks. Our findings call for special consideration and close surveillance of those women with early-onset diseases

Aspects cliniques et évolutifs de la pré-éclampsie sévère traitée à la maternité Befelatanana, Madagascar / Clinical aspects and outcome of severe pre-eclampsia treated at the Befelatanana maternity hospital, Madagascar

Pre-eclampsia is a major public health problem and is one of the main causes of maternal-fetal morbidity. The main objective of this study is to describe the clinical and evolutionary aspects of severe pre-eclampsia. Methods: This was a retrospective, monocentric, descriptive, observational and cross-sectional study of 6 months, from January 01, 2019 to June 30, 2019, conducted at the level of the resuscitation service of the university hospital of gynecology obstetrics Befelatanana (CHU GOB). Results: Three hundred and fourteen (5.10%) cases out of 6153 admissions of severe pre-eclampsia were collected in the study; the average age was 27.29 ±7.47 years. Eclampsia (30.25%, n= 95), retroplacental hematoma (13.38%, n= 42) and acute renal failure (7.96%, n= 25) were the most frequent maternal complications. Maternal prognosis was favorable in 92.36% of cases (n= 290). Maternal death represented 3.18% (n= 10). Prematurity (44.82%, n= 95), fetal hypotrophy (37.26%, n= 79) and fetal asphyxia (14.15%, n= 30) were the most common fetal complications. Fetal death was 26.47% (n= 81). Conclusion: It is necessary to reinforce the information and education of parturients on the first signs for an early detection, diagnosis and management

Magnitude of preeclampsia and associated factors among women attending delivery service in Debre Tabor Specialized Hospital

BACKGROUND: Preeclampsia is among the leading causes of maternal and perinatal morbidity and mortality, and it continues as a global health concern. Therefore, this study was aimed to assess the magnitude of pre-eclampsia and its determinant factors among women attending delivery services in Debre Tabor Comprehensive Specialized Hospital Northwest Ethiopia. METHODS: Institutional-based cross-sectional study was conducted among 261 women from January 1- 30, 2021. A systematic sampling technique was applied. Data were collected using a structured and pre-tested questionnaire. The collected data were entered using Epi-data version 4.2 and analyzed by statistical package for social science (SPSS) version 23. A significant association was declared at a p-value of < 0.05 with a 95% Confidence interval. RESULTS: Overall 15,7% of women had preeclampsia. Age at menarche (10-15 years) (AOR=4.79; 95% CI: 2.07-15.27), unwanted pregnancy (AOR:1.29; 95% CI: 1.59-8.44), history of chronic hypertension (AOR:2.93; 95% CI: 1.00-6.20), BMI ≥ 30 Kg/m2 (AOR:1.79; 95% CI: 1.06-3.65), and alcohol consumption (AOR:2.12; 95% CI: 4.00-14.14) were significantly associated with preeclampsia. CONCLUSION: This study showed that the magnitude of preeclampsia was significantly high compared with previous national reports. Early menarche age, the status of current pregnancies, history of chronic hypertension, BMI, and alcohol consumption were significantly associated with preeclampsia. Therefore, the government and respective stakeholders should be strengthening antenatal care services to early identify and manage women with preeclampsia. Besides, health education and promotion should be strengthened regarding the maintenance of appropriate body weight and alcohol intake before pregnancy

Retinal changes among pre-eclamptic patients in University of Benin Teaching Hospital, Benin, Nigeria

Background: Preeclampsia is one of the hypertensive disorders in pregnancy that contributes significantly to maternal and fetal morbidity and mortality, with the impact felt more in developing countries. It is characterized by endothelial dysfunction and vasospasm of vessels which can be observed by an ocular fundal examination. The aim of this study was to determine the ocular fundus findings of women with preeclampsia. Methods: This was a cross-sectional study, carried out at the University of Benin Teaching Hospital involving a total of 220 pregnant women. The women were divided into two groups of 110 pregnant women (A&B).Their Age and Gestational age was cross-matched and retinopathy graded according to Keith and Wagner classification. Group A was made up of Preeclamptic women and Group B was made up of healthy pregnant women. Visual acuity was measured using Snellens' chart, and the fundus was examined with direct ophthalmoscope. Results: This showed that the retinal changes observed in the preeclamptic women were associated with their age (P = 0.009), gestational age (P = 0.044), blood pressure (P = 0.001), Proteinuria (P = 0.001), Severity of the disease (P = 0.001), visual acuity (P = 0.035) as well as with the visual symptoms (P = 0.001) but not statistically significant with the gravida (P = 0.799). Conclusion: Our study highlights the importance of timely ophthalmoscopy which helps to assess severity of disease (pre-eclampsia) which affects the decision of induction of delivery to predict and prevent possible complications which in turn immensely helps in judicious management of disease. Also, the study revealed that preeclamptic women who are multigravida are more likely to have retinopathy than primigravid

An Evaluation of Risk Factors Associated with Pregnancy Related Acute Kidney Injury in Women Admitted to the High Dependency Care Unit at Women and Newborn Hospital, Lusaka-Zambia

Objective:To evaluate factors associated with Pregnancy-related KidneyInjury(PRAKI) inwomen admitted to high dependency care unit at Women and Newborn Hospital in Lusaka, ZambiaMethodology:This was an unmatched case-control study conducted in the high-dependency care unit at Women and Newborn Hospital in Lusaka. Study participantswererecruitedconsecutivelybyconveniencesampling.Participants'medicalrecords were reviewed to capture serum creatinine levels;whileastructuredquestionnairewasadministeredto eligible andconsentedstudy participants to capture data on sociodemographic, obstetric, and medical factors. Serum creatinine levels above 84µmol/l were used as criteria for classifying PRAKI. Excel was used for data cleaningandStatav13usedforanalysis.Descriptive statistics were done for all variables followed by univariate and multivariable logistic regression to determine association. 95% CI was usedand p value of<0.05 was consideredsignificant.Results:Thestudy comprised of185 study participants, split into 85 women with PRAKI (cases) and 100 women without PRAKI (controls). The median age was 29 years with 11years interquartile range. 75.3%of the study participants wereinmarriagerelationships.Pre-existinghypertension was the most prevalent medical condition in both the cases (51.8%) and the controls (38%). Sickle celldisease was much less common at 1.2% in cases and 8% in controls. Among the obstetric conditions, preeclampsia was the most common condition at 77.6% and 60% in cases and controls respectively. Eclampsia was found in 38.8% of cases and 11% of controls. Sepsis was least common at 4.7% of cases. This study found that obstetricfactorssuch as eclampsia (AOR = 5.12, 95% CI [2.14 ­ 12.23]; p≤0.0001), preeclampsia (AOR = 2.46, 95% CI [1.12 ­ 5.39]; p = 0.025), and postpartum haemorrhage were associated with the development of PRAKI. Medical conditions were not associated with PRAKI.

Hypertensive disorders of pregnancy: A five-year review in Babcock University Teaching Hospital, Ilishan-Remo, Ogun State, Nigeria

Objective: To determine the prevalence and outcome of hypertensive disorder of pregnancy in Babcock University Teaching Hospital, Ilishan-Remo, Ogun State Nigeria Method: This was a retrospective descriptive study of all documented cases of hypertensive disorder of pregnancy between the 1st of June 2012 and 31st May, 2017. Information such as age, parity, booking status, level of education, blood pressure at presentation, urinalysis at presentation, gestational age at presentation, and delivery, mode of delivery, baby's birth weight was extracted from patients' case files. Result: There were 1,118 deliveries during the study period out of which 55 (4.9%) patients had hypertensive disorders in pregnancy. The mean age was 31.5years ±48.1 and mean parity, 1.2± 1.1. The mean systolic and diastolic blood pressures were 180.4 ± 1.88mmHg and 105.1± 1.5mmHg, respectively. Thirty-four (75.5%) of the women had preeclampsia/ eclampsia, while 7 (15.5%) had gestational hypertension. Most women were delivered preterm (22 patients, 48.7%). The majority of them (33, 73.3%) were delivered by cesarean section, out of which 2 (4.4%) were elective cesarean section and 31 patients (68.8%) were emergency cesarean section. The case fatality rate was 1.8%. Conclusion: Pre-eclampsia was the most prevalent t hypertensive disorder of pregnancy. It was more prevalent among primigravidae patients and the most common complication was preterm delivery. Strengthening antenatal care services will enable early identification of cases. Prompt referral of cases for specialist care will help in reducing the adverse outcomes associated with the condition.

Pregnancy induced hypertension and associated factors among women attending delivery service at Mizan-Tepi University Teaching Hospital, Tepi General Hospital and Gebretsadik Shawo Hospital, Southwest, Ethiopia

BACKGROUND: Disorders of pregnancy induced hypertensive are a major health problem in the obstetric population as they are one of the leading causes of maternal and perinatal morbidity and mortality. The World Health Organization estimates that at least one woman dies every seven minutes from complications of hypertensive disorders of pregnancy. The objective of this study is to assess pregnancy induced hypertension and its associated factors among women attending delivery service at Mizan-Tepi University Teaching Hospital, Gebretsadikshawo Hospital and Tepi General Hospital. METHODS: A health facility based cross-sectional study was carried out from October 01 to November 30/2016. The total sample size (422) was proportionally allocated to the three hospitals. Systematic sampling technique was used to select study participants. Variables with p-value of less than 0.25 in binary logistic regression were entered into the multivariable logistic regression to control cofounding. Odds ratio with 95% confidence interval was used. P-value less than 0.05 was considered as statistically significant. RESULTS: The prevalence of pregnancy induced hypertension was 33(7.9%); of which 5(15.2%) were gestational hypertension, 12 (36.4%) were mild preeclampsia, 15(45.5%) were severe preeclampsia and 1 (3%) eclampsia. Positive family history of pregnancy induced hypertension [AOR5.25 (1.39-19.86)], kidney diseases (AOR 3.32(1.04-10.58)), having asthma [AOR 37.95(1.41-1021)] and gestational age (AOR 0.096(0.04-.23)) were predictors of pregnancy induced hypertension. CONCLUSION: The prevalence of pregnancy induced hypertension among women attending delivery service was 7.9%. Having family history of pregnancy induced hypertension, chronic kidney diseases and gestational age were predictors of pregnancy induced hypertension

Comparing perceived social support and perceived stress in healthy pregnant women and pregnant women with preeclampsia

BACKGROUND: Preeclampsia is a prevalent side effect of pregnancy. Different studies have reported different results about the relationship between mental stress and blood pressure disorders. In addition, social support is highly important to help women who experience risky pregnancy in adapting to the stressors they experience. This study aimed to compare perceived social support and perceived stress in women with and without preeclampsia. METHODS AND MATERIALS: Fifty pregnant women definitely diagnosed with preeclampsia and 50 healthy pregnant women visiting public hospitals including Hazrat Masoumeh, Motazedi,and Imam Reza in Kermanshah-Iran took part in a descriptiveanalytical study from June 2017 to January 2018. Data gathering tools included demographics questionnaire, social support appraisals scale and perceived stress scale. The collected data was analyzed with SPSS (v.20) using independent t-test. RESULTS: The mean score of perceived social support in the preeclampsia and non-preeclampsia groups were 69.88±7.3 and 76.80±7.6 respectively (P<0.01). The mean score of perceived stress in the preeclampsia and non-preeclampsia groups were 35.6±8.7 and 26.01±5.56 respectively (P<0.01). This means that compared with healthy women, women with preeclampsia perceived more stress and less social support. CONCLUSION: In comparison with healthy pregnant women, women with preeclampsia perceived more stress and less social support. Healthcare providers should recommended to pay more attention to improving social support and attenuating stress in pregnant women

Pre-eclampsia at Laquintinie hospital (Douala): survey of prevalence and morbidity from 2010 to 2015

Objective: to determine the prevalence of pre-eclampsia and describe its complications at Laquintinie Hospital in Douala. Methods: We conducted a descriptive study with retrospective data collection for 03 months (January 18, 2016 to April 18, 2016) from the records of pregnant women received at the gynecology-obstetrics department over a 6-year period from 1st January 2010 to 31st December 2015 at Laquintinie Hospital in Douala. We identified pregnant women with BP≥140 / 90 mmHg combined with proteinuria> 0.3g / 24h or significant albuminuria (2+) on urine strips after 20 weeks of amenorrhea. Results: Of the 17644 deliveries recorded during our study period, we found 1080 cases of PE, a frequency of 6.12%. PE was common among primi-parous women (46.7%) in the age group [20-29] years. Pregnant women under the age of 20 were the most affected by eclampsia. Preeclampsia was frequently found in pregnant women with twin pregnancies and those with macrosomic fetuses with 10.1% and 8.9% frequency, respectively. Multiparous women with preeclampsia often had a history of PE (43 cases or 4%), arterial hypertension (55 cases or 5.1%) and / or diabetes (5 cases or 0.5%). Eclampsia was the principal maternal complication (29.7%). The maternal case fatality rate was 0.5%. Fetal complications were dominated by induced prematurity (19.5%) and intra-uterine fetal death (9.4%). Conclusion: This study reveals that pre-eclampsia is frequent in Douala Laquintinie hospital with high maternal-fetal morbidity and mortality rate and therefore remains a major public health problem

Factor associated with progression to chronic arterial hypertension in women with preeclampsia in Yaoundé, Cameroon

Introduction: hypertensive diseases in pregnancy are the leading medical problem during pregnancy. Some of the women affected remain hypertensive after pregnancy and the post-partum period. This study aimed to assess the factors associated to the persistence of hypertension after preeclampsia.Methods: this was a retrospective cohort study which included all women who had preeclampsia. The minimal follow-up period was 12 months. We excluded from the study all women who had superimposed preeclampsia. Sociodemographic data and past history were recorded and a physical exam was performed for all participants. Multivariate logistic regression was used to determine factors independently associated to the persistence of hypertension.Results: our cohort consisted of 136 women. The mean follow-up period was 3.7 years. Thirty two women (23.53%) remained hypertensive. This represented an incidence rate of 2.85% per year. Old age (≥ 40 years), housewife occupation, multigravidity (> 4), onset of preeclampsia before 34 weeks' gestation, obesity and the presence of hypertension in siblings were factors independently associated to persistent hypertension. Conclusion: many women affected by preeclampsia remain hypertensive after pregnancy. It is important to provide adequate follow-up for this patients in order to intervene on the factors leading to this outcome

L'hypotension induite par la rachianesthésie lors des césariennes chez les patientes avec pré-éclampsie

Introduction. L'objectif de ce travail était d'étudier l'hypotension au cours de la rachianesthésie pour césarienne chez les patientes présentant une pré-éclampsie (groupe PE) en comparaison avec les patientes non pathologiques (groupe NPE). Patientes et Méthodes. Il s'agit d'une étude prospective et comparative sur six mois après approbation du comité d'éthique de notre établissement. Nous avons inclus les patientes opérées pour césariennes sous rachianesthésie. Le critère de regroupement était la présence ou non d'une pré-éclampsie. Les variables étudiées étaient l'hypotension, sa sévérité et les moyens thérapeutiques. L'analyse statistique a été réalisée avec le logiciel SPSS 20.0, en utilisant les tests de Student, de Man Withney et de Khi 2 avec un seuil de significativité de 0,05. Résultats. Nous avons colligé 113 patientes d'âge moyen de 28,19±6,42 ans, avec un terme moyen de grossesse de 38,41±2,83 semaines d'aménorrhées. Le taux d'hypotension induite était de 65,61% dans le groupe des patientes sans prééclampsie et de 34,67% chez les patientes pré-éclamptiques (p<0,001). Les besoins en éphédrine pour la correction de l'hypotension étaient de 3,45±3,15 mg pour le groupe NPE versus 8,98±4,40 mg pour le groupe PE, (p<0,001), le volume de sérum physiologique perfusé en remplissage vasculaire était de 870,55±181,33 ml (NPE) versus 635,12±99,98 ml (PE), (p<0,001). Conclusion. L'hypotension est moins fréquente et moins sévère chez la pré-éclamptique par apport à la non prééclamptique au cours de la rachianesthésie pour césarienne

Maternal and perinatal outcomes in women undergoing expectant management of early-onset pre-eclampsia: A retrospective cohort study

Background. Expectant management of early-onset pre-eclampsia, with the aim of improving perinatal outcomes, may increase the risk of maternal morbidity. Objective. To study the maternal and perinatal outcomes and their association with various risk factors in women undergoing expectant management for early-onset pre-eclampsia. Methods. A retrospective cohort study was carried out in a tertiary centre in south India between April 2014 and June 2015. We studied 201 women with singleton pregnancies with pre-eclampsia diagnosed between 28 and 34 weeks' gestation. Demographic data, medication and treatment details, and delivery data were extracted from maternal charts. The primary outcomes were: (i) composite maternal outcomes, defined as the development of any of eclampsia, abruptio placentae, pulmonary oedema or renal failure; and (ii) perinatal mortality. Logistic regression was used to assess the independent association risk factors with primary outcomes, after adjusting for other variables. Results. Sixty-nine women (34.3%) had one or more of the composite adverse maternal outcomes, and there were 74 (36.8%) cases of perinatal mortality. The presence of imminent symptoms (odds ratio (OR)=2.35) and multiparity (OR=2.31) were associated with composite adverse maternal outcomes, whereas low birth weight and breech vaginal delivery were associated with perinatal mortality. Perinatal mortality was higher in women with pre-eclampsia diagnosed between 28 and 30 weeks. Gestational age at diagnosis was not found to be associated with composite adverse maternal outcomes or perinatal morbidity. Conclusion. Expectant management in early-onset pre-eclampsia can be safely considered without increasing maternal risk, after thorough counselling about outcomes, based on the available neonatal facilities in low-resource settings

La rachianesthésie pour césarienne d'urgence en cas de prééclampsie sévère : une étude rétrospective de 44 cas

But. L'étude avait pour objectif d'étudier les modalités et le retentissement hémodynamique de la rachianesthésie pour césarienne en urgence dans un pays d'Afrique subsaharienne. Patients et méthodes. Il s'agit d'une étude rétrospective menée à Dakar durang un an, du 1er Janvier 2007 au 31 Décembre 2007 à partir des dossiers anesthésiques. Ont été recrutées toutes les patientes ayant bénéficié d'une césarienne sous rachianesthésie en urgence pour une pré éclampsie sévère. Les variables étudiées étaient les caractéristiques démographiques des patientes, le traitement antihypertenseur, le volume du remplissage, le score d'Apgar, le poids de l'enfant et le retentissement hémodynamique de la rachianesthésie. La pression artérielle systolique, la pression artérielle diastolique et la pression artérielle moyenne étaient mesurées avant et au cours de la rachianesthésie qui était pratiquée par 10 mg de bupivacaïne hyperbare à 0,5% et 2,5 γ de sufentanyl. Résultats. Quarante quatre patientes sur 48 ont été retenues dans l'étude avec un âge moyen de 33± 6,3 ans, des extrêmes de 26 ans et 40 ans et un âge gestationnel moyen de 35± 2 semaines d'aménorrhée (SA) avec des extrêmes de 34 et 37 SA. Le poids moyen des enfants était de 2044± 700 g avec 1340 g et 2750 comme extrêmes, avec un score d'Apgar moyen de 8±1 et des extrêmes de 7 et 9. Dix neuf patientes avaient un traitement antihypertenseur. Le remplissage vasculaire moyen était de 1640 ± 540 ml de Ringer lactate avec des extrêmes de 1000 ml et 2000 ml. Seules trois patientes ont eu des épisodes d'hypotension transitoires. Conclusion. La rachianesthésie est encore réalisable au cours de la pré éclampsie. Le retentissement hémodynamique est faible et sans conséquence pour la mère et l'enfant

Prévalence et facteurs de risque des syndromes vasculo-rénaux en milieu hospitalier à Parakou (Bénin) en 2015

Introduction : L'hypertension artérielle (HTA) au cours de la grossesse est une pression artérielle systolique ≥ 140 mmHg (millimètre de mercure) et/ou une pression artérielle diastolique ≥ 90 mmHg confirmée par deux reprises, chez une patiente assise ou couchée.Objectif : Déterminer la prévalence des syndromes vasculo-rénaux en milieu hospitalier. Méthode : Il s'est agi d'une étude prospective, transversale, descriptive à visée analytique qui s'est déroulée du 1er mars au 31 juillet 2015 en milieu hospitalier à Parakou. Résultats : Deux-mille cinq cent trois (2503) patientes avaient été enregistrées avec 180 cas de pathologies cardiovasculaires dont 155 cas d'HTA (86,11%) soit une prévalence hospitalière de 6,19%. L'HTA gestationnelle (36,13%) et la prééclampsie (39,35%) étaient les plus représentées suivi de l'HTA chronique (11 ; 07,10%) de l'éclampsie (23 ; 14,84%) et de la prééclampsie surajoutée (4 ; 02,58%). Les femmes étaient enceintes (92,90%) et dans les suites de couche (7,10%). L'âge moyen de la grossesse était de 34,8 ± 4,7 avec des extrêmes de 19 et 41 semaines d'aménorrhée. Les facteurs associés à l'HTA étaient le jeune âge ≤ 30 ans (p = 0,007), le bas niveau socioéconomique (p = 0,02), la faible gestité (p = 0,0007) et la faible parité (p = 0,000002)

Early pregnancy plasminogen activator inhibitor-1 levels in Nigerian women and its relationship with preeclampsia

Aim: This study compared early plasma levels of plasminogen activator inhibitor-1 (PAI-1) in normal pregnancy and preeclampsia and determined its relationship with disease severity. Subjects and Methods: This was a prospective cohort study of 195 normotensive, aproteinuric pregnant women without prior history of gestational hypertension. The women were attending the Antenatal Clinic at The Lagos University Teaching Hospital and were within 24 weeks gestation at recruitment. The outcome measures were PAI-1, systolic blood pressure (SBP), diastolic blood pressure (DBP), and significant proteinuria. The endpoint of the study was the development of preeclampsia. The diagnosis of preeclampsia was made by the attending Obstetrician. The data were analyzed using the IBM SPSS statistical software. Statistical significance was set at P < 0.05. Results: First trimester PAI-1 levels were significantly higher in the women who later developed preeclampsia compared to those who had a normal pregnancy (P < 0.0001). In these group of women who later developed preeclampsia, PAI-1 had an inverse relationship with gestational age (r = 0.878) whereas in normal pregnancy, PAI-1 and gestational age had a direct relationship (r = 0.017). Second trimester systolic and DBP values were also significantly higher in the women who later developed preeclampsia compared to normal pregnancy, P = 0.007 and 0.004, respectively. There was, however, no correlation between PAI-1 values and SBP, DBP and proteinuria in the women who developed preeclampsia. Conclusion: Plasma levels of PAI-1 are increased early in pregnancies complicated by preeclampsia, but the lack of correlation of this marker with disease severity may limit its clinical utility

Hypertension in pregnancy among rural women in Katsina State, Nigeria

Hypertension in pregnancy (HIP) is defined as a systolic blood pressure ≥140 or diastolic blood pressure ≥90 mmHg or both. It could be described as chronic, gestational, preeclampsia or eclampsia depending on the gestational period, tendency for postpartum resolution, presence of proteinuria or convulsion. Hypertension in pregnancy affects about 5-22% of pregnancies especially in developing countries. Though preeclampsia and eclampsia seems to create more concern than others, evidence abound that any form of hypertension in pregnancy places women at increased risk of adverse outcomes

Prise en charge de la pré-éclampsie : le pidolate de magnésium injectable peut-il être une alternative au sulfate de magnésium dans les pays à ressources limitées ?

Introduction : La pré-éclampsie et ses complications représentent la deuxième cause de mortalité maternelle dans notre pays. L'administration de magnésium sulfate en IV est la référence du traitement médical, mais le pidolate de magnésium par voie IM peut être une alternative. Méthodes : Il s'agissait d'une étude prospective, comparative, randomisée en double aveugle, menée de janvier 2015 à décembre 2015 à la maternité du centre hospitalo-universitaire (CHU) de Cocody-Abidjan. Tous les cas de pré-éclampsie modérée, soit une pression artérielle systolique ≥ 140 mmHg et une pression artérielle diastolique ≥ 90 mmHg, associée à une protéinurie à 300 mg chez des gestantes porteuses d'une grossesse à 37 semaines d'aménorrhée (SA), ont été retenus (n = 136). Ces gestantes ont été réparties en deux groupes de 68 cas et ont été suivies régulièrement dans l'attente de la décision d'accouchement. Cette surveillance hospitalière comportait, outre un examen obstétrical et général complet, un contrôle horaire systématique de la pression artérielle (PA) et la recherche de la protéinurie aux bandelettes réactives jusqu'à l'accouchement. Le premier groupe de gestantes représentait les cas et a reçu un traitement au pidolate de magnésium injectable (Mag injectable 0,8%®) à raison de 244,2mg de magnésium par jour, réparti en 3 injections intramusculaires (IM) d'une ampoule de 10ml contenant 81,4mg de magnésium, chaque 8 heures. Aux gestantes du 2e groupe, qui représentaient le groupe témoin, il a été prescrit un traitement par le sulfate de magnésium injectable, selon le protocole de l'OMS, soit en traitement d'attaque : 14g en dose de charge répartie de la manière suivante : 10g en IM dont 5g dans chaque fesse et 4g en IV, puis en traitement d'entretien : 1g en IV après chaque 4h jusqu'à l'accouchement. Lorsque persistaient les signes de gravité, la césarienne ou le déclenchement artificiel du travail étaient immédiatement décidés. Ces gestantes ont, parallèlement, reçues un traitement antihypertenseur. L'analyse statistique a consisté en une comparaison de l'issue de la grossesse et la survenue de complications aiguës materno-fœtales de la pré-éclampsie. Le test du khi deux au seuil de signification fixé à 5% (p<0,05) et le t-Student ont été utilisés pour la comparaison des effectifs.Résultats : Nous n'avons pas observé de différence significative concernant l'apparition de complications maternelles (éclampsie, hématome rétro placentaire et HELLP syndrome), ou de complications fœtales (petit poids de naissance, mort fœtale in utero et mauvais score d'Apgar), entre les 2 groupes. Conclusion : Le pidolate de magnésium par voie IM est aussi efficace dans la prévention de la crise d'éclampsie que le magnésium sulfate. Il présente, en outre, l'avantage de sa meilleure disponibilité, d'une facilité d'emploi et d'un coût faible

Blood glucose and serum lipid profiles during pregnancy

Pregnancy is associated with significant changes in the functions of the normal liver and understanding these changes is essential to a proper clinical evaluation of liver abnormalities during pregnancy. This study aimed at determining blood glucose level, triglyceride (TG), high-density lipoprotein (HDL), total cholesterol (TC), and low-density lipoprotein (LDL) in the three trimesters of pregnancy among women in Benin City, Nigeria. This was a prospective cohort study, in which 50 blood samples were collected at each mid trimester of pregnancy. Controls were age-matched, non-pregnant women. Data were analysed using ANOVA and p<0.05 was considered statistically significant. The results showed that glucose concentration was significantly higher in pregnant women than the control group, and it was highest in the third trimester of pregnancy. Lipid profile results showed that TG was significantly lower in the control group than in pregnant women. TG was highest in first trimester pregnancy and least in the control group. HDL was significantly lower in the first trimester than in the control group, second or third trimester. Delayed TG clearance is a function of increased blood TG levels and when this occurs with high blood pressure in pregnancy, it could lead to the development of pre-eclampsia. This association may be significant in understanding the process of pre-eclampsia and may help in developing strategies for prevention and early diagnosis of pre-eclampsia