[Repeatabilifi of ctinico-histopathologiculft.ndings and direct immanoflaotescence offtxed, paraffin embedded specimens fot diugnosis of lichen planas]

Background and. Aim: Lichen planus [LP] is a chronic mucocutaneous disorder mediated by the impaired immunity' in which the concomitance of clinical and histopathological findings are necessary for a definite diagnosis. In case of discrepancy between clinical and histopathological findings, use of adjunct diagnostic methods such as direct immunofluorescence [DIF] is recommended. This study sought to assess the repeatability of clinico histopathological findings and direct immunofluorescence of fixed, paraffin embedded specimens for diagnosis of LP.

Matertuh and Methods: In this retrospective descriptive study, 49 oral and cutaneous LP specimens were subjected to DIF assessment using fibrinogen, c3 and IgM. The intensity of fluorescence staining was graded as 0, I or 2' Findings were compared in each group and between oral and cutaneous LP groups using statistical tests.

Results: Statistical unulyr",, "rr"aled a correlation between C3 and IgM expression [Spearman's rho: 0'697, p=0'000]' which was more prominent in cutaneous specimens [p:0.000]. Additionally, a correlation was observed between fibrinogen and IgM expression in oral LP [Spearman's rho: 0.764, p:0.02].

Conclusion:It seems that DIF assessment of formalin-fixed, paraffrn embedded specimens using C3' fibrinogen and IgM does not have adequate repeatability for clinico-histopathological findings; although, combined application of C3 and IgM in cutaneous uoa IgVt and fibrinogen in oral LP specimens showed higher repeatability.

[Association of vitamin D and cognitive disorders an older population of Amirkola]

Vitamin D receptors are widespread in brain tissue, and the active form of vitamin D has been documented for its neuroprotective effects. This study was conducted to determine the association between vitamin D level and cognitive disorders. This descriptive-analytical cross sectional study was conducted within the framework of the "Amikola Health and Aging Project [AHAP]", [2011-12], conducted on 1616 older people, aged>60 years in the city of Amirkola, Iran. Serum levels of vitamin D were measured in morning blood samples and mental status was investigated using Mini-Mental State Examination [MMSE]. Data was analyzed with T test, ANOVA and Chi-square, and P-values <0.05 were considered significant. The mean age of study participants was 68.81 +/- 7.1 years. Among them 509 [31.5%] had cognitive impairment and 1103 [68.4%] did not. There was significant association between serum vitamin D level and normal and abnormal MMSE in women [P=0.029], but not in men [P=0.49]. Mean serum vitamin D level in participants with normal MMSE was 34.45 +/- 32.79 ng/ml and in participants with abnormal MMSE was 32.80 +/- 29.39 ng/ml but this finding was not significant [P=0.31]. Serum vitamin D level in older persons with normal MMSE was higher than in those with abnormal MMSE, although it was not significant. In this study, there was no association between serum vitamin D levels in older people with or without cognitive impairment

Investigation of the effect of Calendula officinalis extract on preventing radiotherapy-induced oral mucositis

Introduction: The objective of this study was to investigate the effect of Calendula officinalis mouthwash on preventing radiotherapy-induced oral mucositis

Materials and Methods: Patients with head and neck cancers referred to our center for radiotherapy were divided into two groups, one receiving drug and the other group receiving placebo. Patients in the drug group received 2% Calendula extract. Oral Mucositis Assessment Scale was used to evaluate oral mucositis intensity at the end of each week. The scale of mucositis at the end of each week was compared between groups

Results: Calendula extract significantly decreased the intensity of oral mucositis as compared to placebo at the end of the 2nd [p=0.019], 3rd [p<0.0001] and 6th week [p=0.031]

Conclusion: Calendula extract could be effectively used to decrease the intensity of radiotherapy- induced oral mucositis

[Evaluation of discontinuation of antibacterial prophylaxis in children with vesicoureteral reflux]

Vesicoureteral reflex is the most important factor in urinary tract infection. For prevention of urinary tract infection [UTI] in children with vesicoureteral reflux [VUR], prophylactic antibiotics are used, but maybe accompany with uncompliance of the parents and also it must use for long time. So, this study aimed at comporison of evaluation of discontinuation of antibacterial prophylaxis in children with VUR. This semi experimental study was done in 54 children with low grade VUR [1, 2] and higher than 5 years old. None of them have had any episode of UTI since last year. They were divided in two groups, continue and discontinue of prophylactic drugs and were followed for at least one year. Then the risk and episode of recurrent UTI were compared in 2 groups. The data were analyzed by SPSS and P<0.05 was determined as significant. Mean age of patients were 7.8 +/- 2.5 years. Forty two [77.8%] children were girls and others [22.2%] were boys. Five episode of UTI were diagnosed in first group and 7 episodes for second group [P>0.05]. Also the risk of recurrent UTI was 1.5 time in girls. According to this study, discontinuing of prophylactic drug in children with grade I and grade II of VUR and after 5 years old is safe and there isn't increased risk of recurrent UTI

[Comparison of the expression level of P53 and proliferating cell nuclear antigen [PCNA] genes in the inflamed and non-inflamed dentigerous cysts]

The role of P53 and proliferating cell nuclear antigen [PCNA] genes in inflamed and non-inflamed odontogenic cysts is related to cell proliferation but it is unclear. The aim of this study was immunohistochemical evaluation of P53 and PCNA expression in inflamed and non-inflamed dentigerous cysts. In the present study, 23 dentigerous cysts [12 inflamed and 11 non-inflamed] were surveyed. Three microns slices were got from paraffined blocks and stained with P53 and PCNA antibodies by immunohistochemistry. Slides were seen by oral pathologist with optical microscope [Olympus BX41] in x400 magnification and scored by Allred scoring. Data were analyzed by Mann-Whitney test via SPSS software. Percent of stained cells in inflamed compared non-inflamed dentigerous cyst did not show any significant difference for expression level of P53 and PCNA in basal and suprabasal layers [P> 0.05]. It seems that inflammation does not affect on expression level of P53 and PCNA in dentigerous cyst

Chronic diseases among older people in Amirkola, northern Islamic Republic of Iran

This descriptive cross-sectional study was undertaken to describe the prevalence of noncommunicable diseases and their risk factors in elderly people in Amirkola, Islamic Republic of Iran. A total of 1019 people aged 60+ years were assessed using a standard questionnaire and a review of medical records. The most common chronic diseases were cardiovascular disease [29.5%], digestive disorders [28.5%], hypertension [23.6%] and diabetes mellitus [23.5%], while 44.4% of subjects were overweight or obese. Overall, 83.0% of the sample reported at least 1 chronic disease and 64% had 2 or more diseases. In age-adjusted logistic regression analysis, hypertension [OR 3.94, 95% CI: 2.87-5.40] and diabetes mellitus [OR 1.83,95% Cl: 1.32-2.55] were associated with cardiovascular disease, but sex, smoking, overweight and lack of walking were not. The study provides valuable data for planning appropriate health services for elderly people in this area of the Islamic Republic of Iran

[Estimation of mandibular premolar teeth length and mesiodistal width based on panoramic radiograph]

Statement of Problem: In diagnostic studies of dentistry, estimation of the mesiodistal width of the unerupted teeth and the required space for their eruption in relation to the space analysis and evaluation of the root-crow ratio is of great importance

Purpose: This study aimed to evaluate the ratio between the real and radiographic length and mesiodistal width of mandibular premolars and provide a formula for prediction of the teeth length and mesiodistal width

Materials and Method: Fifty six extracted teeth of mandibular first and second premolars of patients and their panoramic radiographs with good quality were collected. The extracted teeth were divided into four groups: T34 [lower left first premolar], T44 [lower right first premolar], T35 [lower left second premolar], and T45 [lower right second premolar]. Then the length and mesiodistal width of both the panoramic images and the extracted teeth were measured. All of the obtained data were analyzed through t-test, two tailed student and linear regression model

Results: It was shown that the vertical magnification of the mandibular first premolars was almost 11.4%-12.1% and that of the mandibular second premolar was almost 16%. The horizontal magnification of the mandibular first premolar was almost 15% and that of the mandibular second premolar was almost 26%. No statistically significant differences were found between the true and radiographic length and mesiodistal width and the magnifications of the left side premolars compared with right side premolars. To determine the real mesiodistal width and length size, some equations are introduced

Conclusion: The panoramic radiographs taken in this research by X-ray imaging machine are feasible and reliable for estimating the actual premolar teeth length and mesiodistal width using specific equations for each teeth in the lower jaw

[Histopathological effect of advanced periodontal disease on the dental pulp]

Statement of Problem: Many authors have claimed that pulpal inflammation may occur following periodontal diseases. Appropriate diagnosis of different lesions that have affected the dental pulp or periodontium is critical for prevention of unnecessary or harmful treatments; this must be taken into account before treatment

Purpose: The purpose of this study was histological evaluation of the pulp in the teeth with advanced periodontitis

Materials and Method: 30 permanent single teeth root that had advanced periodontitis with attachment loss >/= 5 mm at least in one surface were used. The teeth were not maintainable and did not have caries, restoration and any sign of primary trauma from occlusion and did not receive any periodontal professional treatment in the past 6 months with no background of trauma. After clinical and radiographical examination and confirmation of the existence of advanced periodontitis, the teeth were extracted. Then cracks were created in the teeth by special clips. After fixation of the teeth in 10% formalin solution and decalcification by 10% nitric acid, the sections were prepared and stained by hematoxylin and eosin and then evaluated from histological perspectives. The data were analyzed by Spearman correlation coefficient ANOVA, t-test and Kruskal wallis tests

Results: In this survey, we did not find any significant correlation between clinical findings and histopathological situation. The relationship between clinical attachment loss and pulp diagnosis was statistically significant [p =0.043]. Also there was a statistically significant relationship between clinical attachment loss and calcification in the pulp [p =0.014]

Conclusion: According to the result of this research, it seems that periodontal condition affects the pulpal condition and it should be considered in future treatments on these teeth

[Effect of inflammation on expression of Ki67, BCL-2 in odontogenic kertocyst]

Odontogenic keratocyst is a developmental odontogenic cyst. However, inflammation has been reported in the connective tissue layer of this cyst. On the other hand, Ki67 is a proliferation marker while, BCL-2 protein is an anti-apoptotic marker. The aim of this study was to evaluate the effect of inflammation on expression of ki67 and BCL-2 in odontogenic keratocyst. This retrospective descriptive analytic study was conducted with 20 cases of OKC. Specimens were divided into two groups of inflamed [n=10] and none-inflamed OKC. Two sections of 3micro m, and 5fim were dissected from each specimen. This step was followed by Hematoxylin and Eosin staining first and then immunohistochemistry staining was performed using monoclonal antibody for Ki67 and BCL-2. Number of nucleus and cytoplasm of immunostained epithelial cells with Ki67 and BCL-2 in 1000 serial epithelial cells were considered as the labeling index [LI]. Inflammatory infiltration density was recorded for each HPF by looking at the depth of adjacent basement membrane. The average inflammatory score and average labeling index were calculated for further comparison. Data was evaluated using Roc curve and student T-test analysis. The mean Ki67 labeling index in all linings of inflamed and non-inflamed OKC was [19.8 +/- 0.88%], [17.9 +/- 1.03%] respectively. The mean BCL-2 labeling index in all linings of inflamed and non-inflamed OKC was [36.06 +/- 1.09%], [37.2 +/- 0.75%] respectively. The Ki67 and BCL-2 labeling index demonstrated significant differences between inflamed and non-inflamed OKC [P<0.05]. The HPF in inflamed cyst, showed an increase in Ki67 expression and decrease in BCL-2 expression when compared with non-inflamed HPF [P<0.001]. Moderate and severe inflammation can affect the overall proliferation activity of OKC epithelium. An increase in Ki67 expression and decrease in BCL-2 expression can be observed in inflamed OKC especially adjacent to basement membrane

Prevalence of hepatitis A IgG in individuals with chronic hepatitis B infection in Babol

To determine the prevalence of previous hepatitis A virus [HAV] infection in people chronically infected with hepatitis B virus [HBV], we assessed the prevalence of anti-HAV IgG in 392 patients. The study was carried out in Babol, northern Islamic Republic of Iran from September 2004 to March 2005. Prevalence in those aged 10-19 years was 59.4% and was significantly lower than that in those aged 20-29 years [89.8%] and those over 29 years [97.5%]. There was no significant difference in prevalence according to sex or place of residence. A significant proportion of Iranian adolescents and young adults with chronic HBV infection are at risk of contracting HAV infection

Study of relationship of sperm parameters with successful IUI in Fatemeh Zahra Infertility Center in Babol

Intrauterine insemination [IUI] after ovulation induction is one of the infertility treatment methods that is used before more invasive assisted reproductive techniques [ART] because of its simplicity and low expenditures. This procedure is performed in different kinds of sub-fertility such as those related to male factors, cervical factors and unexplained infertility. The aim of this study was to determine the relationship of sperm parameters with IUI success. In this cross sectional descriptive analytical study, 223 infertile couples who had undergone 413 IUI cycles were studied. Sampling method was census and based on available medical records of the patients in 2004. Number of IUI cycle and sperm parameters of the patients were reviewed. Semen analysis was done on the basis of NAFA-ESHRE guide manual [2001]; data were collected and then analyzed statistically by means of X[2], T and Fisher exact tests. p<0.05 was considered significant. Pregnancy rate was 7.7% for every IUI cycle and 14.3% for every couple. Those who had progressive sperm [grade 3 and 4] in their first semen analysis, had more pregnancy rate [19.8% vs. 8.9%] [p=0.016]. Those with 15% and more morphologically normal sperm had higher pregnancy rate [18.3%], but, in other subjects with less than 15%, the pregnancy rate declined to 9.8% [p=0.143]. In the study of sperm count after washing, the pregnancy rate in the wives of the men with total sperm count of more than 20 million was 16%, while total sperm count of less than 20 million, led to a pregnancy rate of 3.4% [p=0.054]. According to our study the existence of progressive sperms [grade 3 and 4] in semen analysis before washing, is one of the most important factors in prediction of IUI success

Clinical symptoms and complications in Iranian troops wounded by chemical weapons [Babol Shahid Yahyanejad Hospital; 2001-2003]

During the Iran-Iraq imposed war, many of Iranian troops were exposed to chemical weapons and now after years of ending the war, many of them are suffering from the outcome of this lethal agent exposure. The purpose of this study was to assess late skin lesions in these individuals. This descriptive study was performed on 198 troops wounded by chemical weapons who were referred to Yahyanejad hospital by Babol Bonyad Janbazan organization. All patients were asked to answer the questions about their diseases and then clinical examinations for skin lesions were recorded and analyzed. All patients complained of skin problems and the most common complaint was pruritus [90.3%]. In clinical examination, the erythema was the most common skin lesion and a skin lesion was seen in 89.9% of the patients. Anterior trunk was the most frequently involved site [33.8%] and the most common disease was chronic urticaria [27.2%].The results show skin lesion due to by chemical weapons may continue overtime. However these complications are not considered as a serious danger to patients' health but they need to be treated

Study of major trauma of genitourinary system in patients referred to emergency center of Babol Shahid Beheshti Hospital [1998-2003]

Trauma is a dynamic process and involves different systems of body according to its severity. Genitourinary system injury is seen in trauma process. This study was done to evaluate the major trauma of genitourinary system with special attention to multiple trauma patients. This descriptive and cross-sectional study was performed on records of 293 patients with genitourinary system trauma who referred to emergency center of Shahid Beheshti hospital from 1998-2004. One hundred and two patients suffering from major trauma of genitourinary system who operated were included in this study. Then necessary information such as sex, age, pattern of trauma, type and mechanism of trauma, involved organ, clinical findings, associated lesions, surgical procedure, laboratory findings, duration of hospitalization and year of admission were obtained and studied. From 102 patients, 92.2% were male and 7.8% were female with mean age of 29.4 +/- 13 years. 33.3% of patients had multiple trauma and 98% of them had blunt trauma. Mean duration of hospitalization was 6.2 +/- 4.4 days. From 13 patients [12.7%] with major kidney trauma, 5 cases had shattered kidney that went under nephrectomy. Only 1 patient [1%] had ureter trauma with final diagnosis of left middle ureter transection. Five patients [4.9%] had intraperitoneal rupture of bladder in which 3 cases had rupture in dome area. Five patients [49%] had urethral injury with clinical findings such as blood at meatus and inability to void. In 50 patients [49%] with penile trauma, 49 patients had penis Fx and 1 case had total amputation of penis and left testis. Fifteen patients [16.7%] had testis trauma in which clinical findings were pain, swelling and ecchymosis. Eleven patients [10.8%] had major trauma of scrotum. According to the results of this study, the most common organ involved in major trauma of genitourinary system was penis. Accurate history and complete physical examination should be considered in patients with multiple trauma

Comparison of Lidocaine and magnesium sulfate on hemodynamic changes in response to endotracheal intubation

Laryngoscopy and endotracheal intubation may produce adverse hemodynamic effects such as hypertension and tachycardia. To attenuate these stimulating responses, various methods and drugs were recommended. The objective of this study was to compare the effect of lidocaine and magnesium sulfate on hemodynamic changes in response to endotracheal intubation. In this study, 100 patients [ASA class I-II] were selected and divided randomly into two groups [50 patients in each group]. Premedication and induction drugs were the same in both groups according to weight. In case group, magnesium sulfates 40mg/kg [50%] and in control group, lidocaine lmg/kg [1%] was used before induction of anesthesia. In both groups, BP and HR checked in all patients and recorded before and after premedication after induction and in the 1st, 3rd, 5th minutes after endotracheal intubation. Data were analyzed by SPSS. T-test was used to compare the mean heart rate and systolic and diastolic blood pressure in different time and p<0.05 was considered significant. Two groups were equal in ASA class, frequency distribution of gender and age, HR, systolic and diastolic BP before and after premedication. But decrease in BP and HR after inducation of anesthesia in control group was more than study group [p<0.05]. There were no significant differences between two groups in mean BP and HR in the 1st, 3rd, 5th minutes after endotracheal intubation. Magnesium sulfate and lidocaine have the same effect on attenuating cardiovascular responses to endotracheal intubation

Fast tracheal intubation with adminstration of ephedrine before atracurium

The most important duty of anesthesiologist is to maintain a secure airway that in emergency patients by injection of intravenous anesthetic drugs such as nesdonal and succinylcholine, tracheal intubation is performed with a 30-45 second delay. But in cases that succinylcholine is contraindicated, nondepolarizing muscle relaxant like atracurium is injected and tracheal intubation is performed with a 3-5 minute delay. The aim of this study was to compare the effect of atracurium and ephedrine with atracurium alone for shortening the time of tracheal intubation. One hundred patients [ASA class I] were randomly divided into two groups of 50 cases. Induction of anesthesia was performed in both groups with nesdonal and then atracurium with dose 0.6mg/kg was administered in both groups. After premedication in case group, ephedrine with dose 70 micro g/kg was performed. In control group, tracheal intubation was performed 3-5 minutes after injection atracurium. Systolic and diastolic blood pressure and heart rate were measured and recorded at different times and also intubaion condition was recorded and data was compared. The mean age was 26.3 +/- 10 years in case group and 31.4 +/- 10 years in control group. In case group, tracheal intubation was performed in all patients during 2 minutes. After anesthesia induction, systolic and diastolic blood pressure decreased and heart rate increased in both groups, but there was a significant difference after intubation at minute 1 and 5 [p<0.05]. Quality of tracheal intubation was seen in 88% of subjects in case group and 96% of subjects in control group, this difference was not statistically significant. Ephedrine can cause a decrease in the onset time of atracurium and faster intubation without adverse hemodynamic effect

Accuracy evaluation of panoramic radiography in detecting the position of third molar roots

Correct radiographic interpretation, especially for root morphology is a useful way to choose open or close surgery and to avoid root fracture during tooth extraction. Since, the third molar has the most irregular and unpredictable root position between all teeth, this study was performed to evaluate the accuracy of panoramic radiography in detecting the position of third molar roots. This cross-sectional and analytical study was performed on 38 patients [49 third molar teeth] who referred to Babol dental school during 2003-2005. Panoramic radiographs were taken from patients in the standard condition and two specialists of oral and maxillofacial radiology and surgery were asked to complete the questionnaire about radiographic interpretation of third molar before surgery. The questionnaire contained the number of tooth roots, relation between roots and relation between root angle and crown. After surgery tooth position was evaluated again. Presurgical and post-surgical radiographic findings were compared and then data were analyzed using paired t-test, X [2], Linear regression and Pearson correlation coefficient. In this study, the accuracy of interpretation of panoramic radiographs in evaluation of number of third molar roots and relation between roots [fused or non fused] was 64.3% and 63.3%, respectively. For the root angle to crown, the radiographic interpretation significantly estimated accurate angle [p<0.0001]. According to the results, panoramic radiography is a useful method for evaluation of the third molar position. Nevertheless, we must be aware of its high diagnostic error rate in evaluation of morphological details of root [number of roots and relation between roots]

Assessment of radiomorphometric and radiomorphologic indices in postmenopausal women

Osteoporosis, the most common metabolic disease, significantly decreases bone mineral density especially among post menopausal women. Techniques of screening osteoporosis are very expensive and needs the skill of an expert. The aim of this study was to assess the radiomorphometric and radiomorphologic indices in post menopausal women. This cross sectional, descriptive and analytical study was performed on 40 postmenopausal women who were referred to the oral and maxillofacial radiology department of the dental faculty in 2004. Mental index [MI], panoramic mandibular index [PMI], mandibular cortical index [MCI] and gonial index [GI] were assessed on their standard panoramic radiographs. Age, menopausal duration, dental condition, educational level, history of fracture and number of deliveries were also recorded and data was analyzed using T test, Man-whitney test, Pearson and Spearman correlation test and regression analysis. Age and menopausal duration have inverse significant correlation with GI, PMI and MI and direct significant correlation with MCI [p<0.001]. Dental condition and educational level significantly correlate with MI [p=0.03, p=0.04] and PMI [p=0.01, p-0.03] while, had no significant correlation with MCI and GI. Number of deliveries and history of fracture had no significant correlation with any of indices. Age and menopausal duration have more effect on MI, PMI, GI and MCI. MI and PMI correlate with more variables and they might be useful for prognosis and screening those patients with low bone mineral density

Biliary pseudolithiasis during ceftriaxone therapy in children

Ceftriaxone is almost widely used in the treatment of pediatric infection and this is accompanied by some complications. The aim of this study was to determine the incidence of abnormal ultrasonography findings of gallbladder [pseudolithiasis or sludge] during ceftriaxon therapy and its relation to fasting, sex and G6PD deficiency. This quasi-experimental survey was done in Amirkola Children's Hospital, Babol, Iran. First ultrasonography was done before initiation of ceftriaxone therapy and it was repeated 24-48 hours after therapy and in the 5th, 7th, 10th and 14th day after the treatment. If abnormal finding was seen, ultrasonography was done weekly in the first two weeks until the side effect disappeared. Data was collected and analyzed by SPSS software. Of all 108 patients, who were between 3 months to 10 years old, 20 cases had abnormal findings in gallbladder [2 sludges and 18 pseudolithiases]. Length of fasting before ceftriaxone therapy had a positive relation with possibility of stone formation [p<0.005], but age, sex, duration of therapy and G6PD deficiency were not related [p>0.05]. In four cases pseudolithiasis was formed after only 1-2 doses of ceftriaxone. Shortest and longest periods of resolution of complications were 1 and 17 days respectively after formation. Incidence of pseudolithiasis or sludge formation during ceftriaxone therapy was 18.5% and fasting had a great effect on these complications

[A study on prevalence of Pediculosis in the primary school students of Babol [2003-2004]]

Regarding the role of lice in the transmission of different diseases, and also as an important agent of determining the hygiene level in the society. This study was performed to assess the prevalence of pediculosis in primary school students of Babol in 2003-2004. In this study, from 15500 primary school students in Babol, 2300 ones [girl and boy] were assessed. Cluster sampling was done in girl and boy school. Data was collected by questionnaire containing personal and family characteristics. Findings showed that 51 students [%2.2] were infected to pediculosis [head lice or nit] and only in two samples live head lice were found. Prevalence of infestation was significantly higher in girls [%3.48] than boys [%0.96] [p<0.000]. Prevalence of pediculosis in students had a significant correlation with fathers' education [p<0.005] and number of children in family [p=0.018]. The results showed that the prevalence of pediculosis in students of Babol was almost low. Since the father's educational level of students who were infested to pediculosis was lower than other educational level of other students' fathers, so it is recommended that necessary actions be taken to promote public knowledge in order to control and prevent pediculosis

[Effect of smoking on salivary composition in subjects with moderate periodontitis before and after periodontal therapy]

There are many researches regarding association between periodontal problem and smoking but there are a few studies about this relationship and the changes in salivary composition. The aim of this study was to evaluate the effect of smoking on salivary composition in subjects with moderate periodontitis before and after periodontal therapy. In this study saliva samples were taken from 30 patients [15 smokers and 15 nonsmokers] with mean age of 33 who referred to periodontal clinic of Babol dental faculty. Laboratory parameters were SIgA, SIgG, Na, K, Ca, P, Mg, Albumin and Amylase. Salivary sampling was done in two stages before and after scaling. Data were analyzed using paired t-test and t-test. The concentration of SIgA, K and P were greater in smokers before therapy [p<0.05]. Post treatment, K and P level were greater in smokers [K=18.8 +/- 0.57, P=11.27 +/- 0.8] than nonsmokers [K=16.78 +/- 0.43, P= 8.83 +/- 0.8] and Mg was greater in nonsmokers [2.73 +/- 0.55] than smokers [1.16 +/- 0.13] [p<0.05]. There was a reduction of SIgA and Mg in smokers after treatment [P<0.05]. The reduction of SIgA in smokers [0.08 +/- 0.011] was greater than nonsmokers [0.03 +/- 0.012] [p=0.005]. Post treatment nonsmokers had reduced SIgA level and increased Ca concentration [p<0.05]. There was a reduction in SIgA level after treatment in both groups, which is related to decrease of inflammation. Smoking has not any considerable effect on salivary composition changes after periodontal therapy