ABSTRACT
Objective: To study the chemical constituents from the aerial parts of Hypericum beanii. Methods: Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results: Fifteen compounds were isolated from the aerial parts of H. beanii. Their structures were identified as hyperbeanol E (. 1), (E)-linalool-1-oic acid (. 2), (4S,5R)-5-(4'-methyl-3'-pentenyl)-4-hydroxy-5-methyl-dihydrofuran-2-one (. 3), benzoic acid (. 4), 4-(3-O-3')-3'-methylbutenyl-6-phenyl-pyran-2-one (. 5), 4-hydroxy-4a,7-dimethoxy-4,4a-dihydrodibenzo-p-dioxin-2(3H)-one (. 6), isoimperatorin (. 7), 2,3-dimethoxyxanthone (. 8), 3,4-dihydroxy-2-methoxyxanthone (. 9), osajaxanthone (. 10), nigrolineaxanthone F (. 11), hypercohone G (. 12), betulinic acid (. 13), oleanolic acid 3β-caffeate (. 14), and isoastilbin (. 15). Conclusion: Compound 1 is a new menthane monoterpene derivative which owns an extra lactone ring. Compounds 2-7 and 10-15 are isolated from genus Hypericum Linn. for the first time and the other compounds are first obtained from the plants in H. beanii.
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Objective: To study the chemical constituents from the root barks of Morus alba. Methods: Various chromatographic techniques were used to separate the constituents and their structures were elucidated on the basis of extensive spectroscopic interpretation. Results: Six compounds were isolated from the root barks of M. alba. The structure of new compound, named as albafuran D (1), was established together with known compounds sanggenon H (2), kuwanon E (3), kuwanon U (4), kuwanon F (5), and benzokuwanon E (6). Conclusion: Compound 1 is a new geranylated 2-arylbenzofuran.
ABSTRACT
Objective: To study the chemical constituents from the aerial parts of Euphorbia altotibetica. Methods: The compounds were isolated and purified by various chromatographic techniques and their structures were elucidated by spectral analysis. Results: Six compounds were isolated and their structures were identified as altotibetin E (1), proline (2), corchoionoside C (3), icariside B2 (4), 1-O-(9Z,12Z,15Z-octadecatrienoyl)-2-O-hexadecanoyl-3-O-α-(6-sulfoquinovopyranosyl) glycerol (5), and (2S)-2,3-O-dioctadeca-9Z, 12Z,15Z-trienoylglyceryl-6'-O-(α-D-galactopyranosyl)-β-D-galactopyranoside (6). Conclusion: Compound 1 is a new cembranoid diterpene named altotibetin E, compounds 2, 5, and 6 are isolated from the species of Euphorbia L. for the first time and the other compounds are firstly obtained from this plant.
ABSTRACT
Objective: To study the chemical constituents from the roots of Campanumoea javanica and their antiangiogenesis activities. Methods: The compounds were isolated and purified by various chromatographic techniques and their structures were elucidated by spectral analysis, the antiangiogenic activities of the isolated compounds were evaluated using a zebrafish model. Results: Fourteen compounds were isolated and identified from 90% ethanol extract in ethyl acetate fraction in the roots of C. javanica, including campanumoside (1), lobetyol (2), tetradeca-4E,8E,12E-triene-10-yne-1,6,7-triol (3), 9-(tetrahydropyran-2-yl)-non-trans- 8-ene-4,6-diyn-3-ol (4), 9-(tetrahydropyran-2-yl)-nona-trans,trans-2,8-diene-4,6-diyn-1-ol (5), lobetyolinin (6), (Z)-3-hexenyl-O- α-L-arabinopyranosyl-(1→6)-β-D-glucopyranoside (7), 3,4-dihydroxybenzoic acid (8), tangshenoside II (9), zanthocapensol (10), ampelopsin (11), agathisflavone (12), β-ecdysterone (13), and α-tocopherolquinone (14). Conclusion: Compound 1 is a new polyacetylene glucoside named campanumoside. Compounds 2-14 are isolated from the plants of Campanumoea Bl. for the first time. Compounds 3 and 4 exhibit the certain antiangiogenic activity in the pharmacological evaluation with a zebrafish model.
ABSTRACT
AIM@#To investigate the chemical constituents and their biological activities of the aerial parts of Euphorbia tibetica.@*METHOD@#Compounds were isolated and purified by various chromatographic methods, and their structures were elucidated through the use of extensive spectroscopic techniques including 2D-NMR, the structures of compounds 5 and 6 were confirmed by single-crystal X-ray crystallography. Bioactivities of all the isolated compounds were evaluated by the MTT method on A549 and anti-angiogenesis assay.@*RESULTS@#One new compound, methyl 4-epi-shikimate-3-O-gallate (1), together with twenty-three known constituents (2-24) were isolated from the aerial parts of E. tibetica.@*CONCLUSION@#Compound 1 is new, and the other compounds were isolated from this plant for the first time. Compounds 5-7, 9, 11, 17, 18 and 20 exhibited inhibitory effects on the growth of human lung cancer cell A549 and compounds 5, 7, 12, 13, 17 and 19 showed anti-angiogenic effects in a zebrafish model.
Subject(s)
Animals , Humans , Angiogenesis Inhibitors , Chemistry , Pharmacology , Cell Line , Cell Proliferation , Drugs, Chinese Herbal , Chemistry , Pharmacology , Euphorbia , Chemistry , Growth Inhibitors , Chemistry , Pharmacology , Molecular Structure , ZebrafishABSTRACT
Objective: To study the chemical constituents from the stem barks of Engelhardtia roxburghiana. Methods: The compounds were isolated and purified by various chromatographic techniques and their structures were elucidated by spectral analysis. Results: Ten compounds were obtained and identified as eudesm-4(15)-ene-1β, 6α-diol (1), (4S)-4-hydroxy-1-tetralone (2), (-)- regiolone (3), p-hydroxybenzoic acid (4), kaempferol (5), isolicoflavonol (6), broussoflavonol F (7), broussonol E (8), kaempferol-3-O- α-L-rhamnoside (9), and quercetin-3-O-α-L-rhamnoside (10). Conclusion: Compounds 1, 4, and 6-8 are isolated from the plants of Engelhardtia Leschen. et Bl. for the first time, and the prenylated flavonoids are firstly reported in this genus.
ABSTRACT
Objective: To study the chemical constituents in the aerial parts of Euphorbia royleana. Methods: The constituents were isolated and purified by chromatographic of silica gel, Sephadex LH-20, RP18, and MCI columns, and their structures were elucidated by spectroscopic analyses. Results: Twelve compounds were isolated from the 70% acetone extracts in the aerial parts of E. royleana and their structures were identified as (6S, 9R)-roseoside (1), 13-carboxyblumenol C 9-O-β-glucoside (2), 3, 3'-dimethylellagic acid-4-O-β-D-glucopyranoside (3), cycloart-23-ene-3β, 25-diol (4), 23(E)-25-methoxycycloart-23-en-3β-ol (5), α-amyrin (6), triptohypol F (7), 9(11), 12-dieneoleana-3β-ol (8), friedelane-3β, 29-diol (9), D:A-friedoolean-29-ol-3-one (10), dischidiol (11), and lupeol (12). Conclusion: Compounds 1, 2, 7-11 are obtained from the plants in Euphorbia L. for the first time and compounds 3-5 and 12 are isolated from this plant for the first time.
ABSTRACT
Sixteen compounds were isolated from the aerial parts of Euphorbia sikkimensis by means of various chromatographic techniques such as silica gel, Sephades LH-20 and RP-18, and their structures were elucidated as naringenin (1), kaempferol (2), quercetin (3), kaempferol-3-O-alpha-L-arabinopyranoside (4), quercetin-3-O-alpha-L-arabinopyranoside (5), quercetin-3-O-(2"-galloyl)-alpha-L-arabinopyranoside (6), 5alpha, 8alpha-epidioxy-(22E, 24R)-ergosta-6,22-dien-3beta-ol (7), stigmast-5-ene-7-one-3beta-ol (8), 3beta-hydroxy4a, 14alpha-dimethyl-5alpha-ergosta-8, 24(28)-dien-7-one(9), beta-sitosterol (10) , 10-cucurbitadienol( 1) , scopoletin(12) , ethyl gallate(13), p-hydroxybenzaldehyde (14), 3 betahydroxybenzeneethanol( 15) ,and 2,4-dihydroxy-6-methoxy-acetophenone (16) on the basis of spectroscopic data analysis. All the compounds are isolated from this plant for the first time, and compounds 1, 4-8, 15 are obtained from Euphorbia species for the first time.