ABSTRACT
A simple and rapid spectrophotometric assay for the determination of metoclopramide hydrochloride in pure and dosage forms has been developed. It is based on the reaction between metoclopramide and 3-methyl-2-benzothiazolone hydrazone in the presence of ferric chloride to give a coloured product with a maximum absorbance at 556 nm. The results obtained are reproducible with a coefficient of variation less than 2% and in a good agreement with the official method. The proposed method is also applicable to urine samples
Subject(s)
Spectrophotometry/methodsABSTRACT
A simple, rapid and direct method for the determination of thymol and eugenol in volatile oils was presented. It was based on the reaction of these compounds with 3-methyl-2-benzothiazolone hydrazone hydrochloride in the presence of cerric ammonium sulfate and direct measurement at 510 nm. The results obtained were encouraging and reasonably reproducible with a relative st and ard deviation less than 1%
Subject(s)
Thymol/analysis , Eugenol/analysis , Colorimetry/methodsABSTRACT
Two simple sensitive and accurate methods for the quantitative determination of minoxidil in pure and tablet forms are described. One method is based on recording the first and second derivative curves of minoxidil using the peak-height technique. The other is based on the reaction of minoxidil with 7, 7, 8, 8- tetracyanoquinondimethane [TCNQ] with the formation of stable and highly colored product exhibiting maximum absorption at 842 nm. The two methods are applied to the determination of minoxidil in pure and tablet form with a coefficient of variation less than 1%
Subject(s)
Spectrophotometry , ColorimetryABSTRACT
A simple and rapid colorimetric method for the determination of bamipine hydrochloride, in powder and in tablet forms, was presented. The method was based on the reaction between bamipine hydrochloride and 3-methyl-2-benzothiazolone hydrazone hydrochloride, in the presence of ferric chloride, to give a blue color with a maximum absorbance at 606 nm and a second-derivative peak-trough at 626-600 nm. Beer's Law is obeyed over a concentration range of 0.4-2.4 mug ml -1 and 0.2- 1.2 mug ml -1 for the two techniques, respectively. The method has been applied for the determination of the drug in powder and in tablets and proved to be reproducible with coefficient variation less than 1%
Subject(s)
Colorimetry/methodsABSTRACT
Derivative spectrophotometric methods were described for the determination of metoclopramide HCl and lignocaine HCl in dosage forms. The first drug was determined in suppositories, syrups, ampoules, tablets and drops. The second was determined in vials, jelly and ointments. The methods were efficient to correct for the interference due to additives viz. parabens and coadministered drugs as paracetamol and naphazoline. Results obtained were accurate with coefficient of variation less than 2%