DIVERSITY OF NON-TIMBER FOREST PLANT PRODUCTS IN THE WEEKLY MARKETS OF MAIBONG SUB-DIVISION, DIMA-HASAO DISTRICT, ASSAM.

Weekly markets of Manderdisha, Hatikhali, Lungting, Maibong have been surveyed at different seasons for one year. The Non-Timber Forest Plant Products were documented through interview with vendors and buyers, personal observation and these are documented with scientific names/families, local(Dimasa) names, plant parts used , purpose of use and selling price. Forty (40) plant species belonging to nineteen(19) different families and thirty nine (39) genera were collected and documented. Among these fifteen (15) were recorded as medicines,twenty (20) as food and five (5) for other utility. 95% of the vendors are ladies suggesting their valuable contribution to family for sustenance and they are good informants also. Conservation practices are not scientific and suggestions have been included in this paper.

Real-world use of once-weekly semaglutide in Thai patients with type 2 diabetes mellitus in a private hospital setting / Journal of the ASEAN Federation of Endocrine Societies

Objective@#To evaluate the real-world use of once-weekly semaglutide among Thai patients with type 2 diabetes (T2DM) in a private hospital setting.@*Methodology@#A retrospective review of Thai patients with T2DM who have initiated semaglutide for at least 1 month between June 2020 and March 2022 at Theptarin Hospital, Bangkok, Thailand.@*Results@#A total of 58 patients (50% female, mean age 55.6 ± 15.9 years, with duration of diabetes 12.6 ± 10.3 years, BMI 31.5 ± 4.4 kg/m2, baseline HbA1c 7.9 ± 1.9%, with prior GLP-1 RA use 24.1%, and concomitant SGLT2i intake (41.4%) were included. During a median follow-up of 6 months, the mean serum HbA1c level reduction was 1.3 ± 1.7% with weight loss of 4.7 ± 4.1 kg. The proportion of patients who achieved optimal and sustainable glycemic control (HbA1c <7.0%) increased from 43.1% to 55.8% at the last follow-up. The proportion of patients reaching both HbA1c targets of <7.0% and 5% weight loss was 27.8%. No cases of pancreatitis, cancer, or progressive retinopathy were observed.@*Conclusion@#In this single center undertaking, it was shown that in among persons with T2DM and obesity in Thailand, semaglutide was associated with short-term glycemic control and weight loss comparable with what has been observed in randomized clinical trials and other RWE.

Effects of resistance training on consecutive and non-consecutive days on hormonal, neuromuscular and morphological responses in recreationally trained men / Efeitos do treinamento de força em dias consecutivos e não consecutivos nas respostas hormonal, neuromuscular e morfológica em homens treinados recreacionalmente

abstract The purpose of the present study was to investigate the effect of two recovery periods between consecutive and non-consecutive days in strength training sessions on hormonal, neuromuscular and morphological variables in recreationally trained men. Nineteen young men completed the study and were randomly divided into two groups: 24R, 24-hour recovery group (n = nine) and 72R, 72-hour recovery group (n = ten). The strength training program (RT) lasted six weeks with two serial routines, with a weekly frequency of four times. The saliva sample was collected once a week in the morning to determine salivary testosterone. The 1RM, jump against movement and body composition tests were performed in the pre- and post-training periods. As for salivary testosterone, there was no significant effect with respect to time and between groups. Both groups improved maximal strength in terms of intervention time in the barbell bench press and in the leg press 45º, not differing between groups and body composition showed significant interaction in time to body fat percentage ∆% = -14.6 ± 10.0 (24R) and -17.2 ± 10.9 (72R); p = 0.00, fat mass ∆% = -13, 7 ± 9.2 (24R) and -18.2 ± 13.0 (72R); p = 0.00 and fat-free mass ∆% = 3.5 ± 2.7 (24R) and 2.5 ± 2 .8 (72R), p = 0.00. The recovery periods 24 and 72 hours between sessions induced similar responses in the parameters investigated in recreationally strength-trained men.

resumo O objetivo do presente estudo foi investigar o efeito de dois períodos de recuperação entre dias consecutivos e não consecutivos em sessões de treinamento de força sobre variáveis hormonais, neuromusculares e morfológicas em homens treinados recreacionalmente. Dezenove homens jovens completaram o estudo e foram divididos aleatoriamente em dois grupos: 24R, grupo de recuperação de 24 horas (n = nove) e 72R, grupo de recuperação de 72 horas (n = dez). O programa de treinamento de força (TF) durou seis semanas com duas rotinas seriadas, com frequência semanal de quatro vezes. A amostra de saliva foi coletada uma vez por semana no período da manhã para determinação da testosterona salivar. Os testes de 1RM, salto contra movimento e composição corporal foram realizados nos períodos pré e pós-treinamento. Quanto à testosterona salivar, não houve efeito significativo em relação ao tempo e entre os grupos. Ambos os grupos melhoraram a força máxima em termos de tempo de intervenção no supino reto com barra e no leg press 45º, não diferindo entre os grupos e composição corporal apresentaram interação significativa no tempo para percentual de gordura corporal ∆% = -14,6 ± 10,0 (24R) e -17,2 ± 10,9 (72R); p = 0,00, massa gorda ∆% = -13, 7 ± 9,2 (24R) e -18,2 ± 13,0 (72R); p = 0,00 e massa isenta de gordura ∆% = 3,5 ± 2,7 (24R) e 2,5 ± 2,8 (72R), p = 0,00. Os períodos de recuperação de 24 e 72 horas entre as sessões induziram respostas semelhantes nos parâmetros investigados em homens treinados de força recreacionalmente.

Covid-19 Hazard Index: A Spatiotemporal Risk Forecast Tool

Background: In each geographic region, risk of new cases of COVID19 are driven by internal factors such as agent, host, and environment characteristics, as well as external factors, such as population mo-bility and cross border transmission of disease. COVID19 control measures are best implemented when local governments and health teams are well aware of these internal and external risks. These risks are dynamic in nature and hence need to be reviewed at regular intervals. The study conducted to develop a composite spatiotemporal Hazard Index comprising of three factors – presence of susceptible popula-tion, population density and presence of active cases with corresponding growth rates, to rank areas within an administrative boundary by their fortnightly risk of active COVID19 cases. Methods: Using Principal Component Analysis, the weights of each of these factors were determined and applied to transformed values of factors in the districts of Gujarat state for months of January to July 2021. Hazard Index thus obtained was used to rank the districts. Results: Spearman correlation between the Hazard Index and number of active cases 15 days later was moderate and significant (p<0.01) throughout the study period. Conclusion: Hazard Index can predict Districts at highest risk of active cases in the given time period. These districts with high Hazard Index would require different control measures, depending on the fac-tor that resulted in higher index value.

A prospective comparative study of concurrent chemoradiation in advanced carcinoma cervix patients with weekly cisplatin vs. weekly cisplatin and paclitaxel

Background: Cisplatin-based concurrent chemoradiation is the standard treatment for carcinoma cervix. However, there is a need to explore alternative chemotherapeutic agents to further improve the treatment outcome. In this study, weekly paclitaxel and cisplatin-based chemoradiation was compared with weekly cisplatin-based chemoradiation in terms of disease control and toxicity profile. Materials and Methods: Sixty-four patients with FIGO stage IB2-IIIB squamous cell carcinoma of the uterine cervix were divided (by simple random sampling) into two groups: control arm patients who received radiotherapy (50 Gy in 25 fractions over 5 weeks) with concurrent weekly cisplatin (40 mg/m 2 ) and study arm patients received same radiation dose with weekly cisplatin (30 mg/m2 ) and paclitaxel (40 mg/m2 ). After that, all patients received brachytherapy 21 Gy/three fractions, one fraction/week. All patients were followed up weekly during treatment, then 4–6 weeks after treatment completion, and thereafter monthly for at least 6 months. Results: The overall treatment response (complete+ partial response) was numerically higher in the cisplatin- containing control arm, but not significant (93% vs. 80%, P-value = 0.406). High-grade early rectal (60% vs. 25%, P-value = 0.014) and acute gastrointestinal toxicity (66% vs. 6%, P-value <0.001) were significantly higher in the cisplatin and paclitaxel-containing arm. Hematological, renal, late rectal, and bladder toxicities were also numerically higher in the study arm, but not statistically significant. Conclusion: There was no significant benefit of weekly paclitaxel and cisplatin as an alternative to weekly cisplatin-based chemoradiation in the treatment of carcinoma cervix.

Prevalence of Anaemia among Adolescent Girls on Weekly Iron and Folic Acid Supplementation (WIFS) and Non WIFS Group in Rural Schools of Mangalore, Karnataka; a Comparative Study

Background: Weekly Iron and Folic Acid Supplementation (WIFS) Programme is an initiative to decrease the burden of anaemia among adolescents studying in Government schools. Objective: To assess the difference in prevalence of anaemia among Government school-going adolescents girls on WIFS as compared to private school girls not on WIFS. Methods: Cross-sectional study was conducted among adolescent girls, 7th to 10th standard in Government schools (on WIFS) and private schools (not on WIFS). The sample size in each group was 104, selected by multi-stage sampling. Data was collected using semi-structured questionnaire, clinical examination and haemoglobin estimation. Chi-square test and Unpaired t test used to compare the categorical and continuous variables respectively. Results: The prevalence of anaemia among the school children in government schools was 51% and in the private schools it was 64.4%. The mean haemoglobin was 11.77 � 1.41 and 11.34 � 1.49 in government and private school girls, respectively, which was statistically significant (p=0.013). Conclusions: The prevalence of anaemia among the government school girls was lesser as compared to the private schools girls, suggesting the role of WIFS in the reduction of prevalence of anemia. WIFS programme may be extended to private schools as well.

Organizing Information on “Dangerous Drugs” Published in Weekly Magazines and Evaluating Its Relevance / 医薬品情報学

Objective: Recently, special features on “dangerous” prescription drugs have been frequently published in few mass media platforms, such as weekly magazines. However, to our knowledge, there have been no prior studies, systematically organizing and evaluating the contents of these articles (e.g., drugs and their side effects that are reported). In this study, we aimed to evaluate the relevance of the information on “dangerous drugs” that was published in weekly magazines using the modified “Media Doctor” instrument.Methods: We extracted articles on “dangerous” prescription drugs from 10 weekly magazines for which the table of contents of previous issues are available on their official websites. Information regarding the target drugs and their classifications was compiled and organized. The relevance of the extracted news articles was assessed by two independent evaluators. The evaluation index was based on the modified “Media Doctor” instrument, and 9 evaluation criteria were used to assign the following categories: satisfactory, unsatisfactory, or not applicable.Results: A total of 1,064 articles were screened, and 19 articles were selected for further evaluation. A total of 179 drugs (belonging to 34 drug classes) were listed. The most frequently mentioned class of drugs included hypnotics and sedatives, and the most frequently listed was triazolam. Of the 19 articles, 11 had zero items that were judged satisfactory by both the evaluators. The number of unsatisfactory items was widely distributed, but in 11 of the 19 articles, five and more items were judged unsatisfactory by both the evaluators.Conclusion: We revealed that a wide variety of drugs have been termed as “dangerous” by weekly magazines. Additionally, we found that these articles were inadequate and incomplete with respect to scientific validity, and that there are many aspects that require further improvement.

Effect of weekly versus daily primaquine on Plasmodium vivax malaria recurrences: A real-life cohort study

ABSTRACT Background: Although primaquine (PQ) is indicated for G6PD-deficient patients, data on weekly PQ use in Brazil are limited. Methods: We aimed to investigate malaria recurrences among participants receiving daily and weekly PQ treatments in a real-life setting of two municipalities in the Amazon between 2019 and 2020. Results: Patients receiving weekly PQ treatment had a lower risk of recurrence than those receiving daily PQ treatment (risk ratio: 0.62, 95% confidence interval: 0.41-0.94), using a model adjusted for study site. Conclusions: Weekly PQ use did not increase the risk of malaria recurrence. Further studies with larger populations are warranted.

Improving maternal nutrition in public health facilities by strengthening the dietary component of Janani Shishu Suraksha Karyakram – A government of India programme

@#Introduction: The Janani Shishu Suraksha Karyakram (JSSK) is a government of India initiative for all pregnant women visiting public health facilities, with many free entitlements – free diet being one. After an in-depth study of existing dietary provisions in all community health centres, an elaborate cyclic-weekly nutritious menu was designed taking into consideration the latest recommendations (2019) by the Ministry of Family and Child Welfare, India to improve maternal health nutrition. Methods: The health functionaries from all ten community health centres of rural Vadodara were chosen for an in-depth estimation of the different meals served in the facilities. Standard measuring cups and spoons were used to measure the exact serving sizes for each person. Each meal served was supervised, checked and quantified in triplicate, while macro- and micronutrients were calculated using the Indian Food Composition Tables 2017 (Longvah et al. 2017). To bridge the gap in service delivery, two new models of cyclic-weekly menu were developed, keeping in mind the amount per mother per day as one hundred Indian rupees. Results: On average the foods served in the community health centres provided 69% of recommended energy intake, while mean recommended dietary allowance met for protein was 51%, calcium 18%, iron 50%, and fat 267%. Conclusion: The recommendations specified in this paper would improve the nutritional status of all pregnant and lactating women availing the services in rural health facilities, which would go a long way in ensuring safe and healthy motherhood.

The acceptability of weekly iron-folic acid supplementation and its influencing factors among adolescent school girls in Yogyakarta city: a mixmethods study

@#Introduction: Indonesia has initiated the weekly iron-folic acid supplementation programme (WIFS) among adolescent school girls since 2016. However, its acceptability needs to be investigated. This study aimed to assess the acceptability of WIFS and its influencing factors. Methods: A mixed-methods study was conducted in six schools in Yogyakarta from January-April 2018. Totally, 211 participants aged 12-18 years were involved in the cross-sectional survey, followed by four focus group discussions (FGDs) and in-depth interviews (IDIs). Body mass index-for-age, haemoglobin, serum ferritin, habitual intake, and acceptability (defined as selfreported iron folic acid tablet consumption) were assessed. Results: This study reported that 22.3% and 12.4% of the participants were categorised as iron deficient and anaemic, respectively. Almost 90% of participants had received the tablet, but only 62.0% of them reported consuming it. Logistic regression test indicated that the participants were more likely to take the tablet if it tasted good [OR (95%CI): 4.66 (1.90-11.43)]. Meanwhile, motivation for tablet consumption declined when respondents perceived the odour of tablet was unpleasant, reported forgetfulness, lacked peer support, and experienced side effects, with OR (95%CI) of 0.23 (0.07- 0.77), 0.35 (0.13-0.95), 0.30 (0.08-0.58), and 0.04 (0.04-0.39), respectively. The results from FGD and IDIs strengthened the findings that the experience of nausea, organoleptic properties of iron-folic acid tablet, forgetfulness, and mother’s support play important roles in students’ acceptability. Conclusion: This study found moderate acceptability towards the WIFS programme. The inhibiting and reinforcing factors of WIFS acceptability in this study could be considered as inputs for programme improvements in the future.

Reliability and Validity of the Chinese Version of Weekly Calendar Planning Activity for Executive Function Assessment in Community-dwelling Middle-aged and Elderly Adults / 中国康复理论与实践

Objective:To examine the reliability and validity of a performance-based executive function assessment, the Chinese Version of Weekly Calendar Planning Activity (WCPA-C), in community-dwelling middle-aged and elderly adults. Methods:From July to August, 2020, 55 community-dwelling adults aged 41 to 89 years participated in this study. A total of 30 participants were evaluated with the WCPA-C version A. After two weeks and four weeks, they were retested with version B and version A, respectively. The intraclass correlation coefficient (ICC) was calculated. All the participants were divided into the mild cognitive impairment (MCI) group (n = 37) and normal cognition (NC) group (n = 18) according to the scores of the Montreal Cognitive Assessment (MoCA). The results of WCPA-C between two groups were compared. Results:There were four participants lost, and 26 participants completed all three tests. Except the planning time, the ICCs were 0.43~0.78 between the first and the second tests, and were 0.50~0.80 between the second and the third tests. WCPA-C results were significant different between two groups (Z > 1.288, P < 0.05), except the total time and the planning time (Z < 1.641, P > 0.05). Conclusion:WCPA-C demonstrats satisfactory test-retest reliability and discriminative validity in community-dwelling middle-aged and elderly adults.

Weekly versus daily Levothyroxine Tablet Replacement in Adults with Hypothyroidism: A meta-analysis / Journal of the ASEAN Federation of Endocrine Societies

Objectives@#Daily levothyroxine is the treatment of choice and standard of care in hypothyroidism, sufficient to restore thyroid stimulating hormone (TSH) to normal range. For many patients, daily lifelong therapy is required, making adherence a major issue. In such cases, weekly replacement may be a suitable alternative to improve adherence. In this study, we aimed to determine the efficacy and safety of weekly levothyroxine replacement among adults with hypothyroidism.@*Methodology@#Electronic databases were searched. Two reviewers (HCC and RBL) independently screened the abstracts, reviewed full-text papers, critically appraised the quality of included studies using PRISMA guidelines. Meta-analysis was performed using the random-effects model. The primary outcome is the difference in serum TSH levels between weekly and daily administration, while secondary outcomes included adverse events and symptoms of hypothyroidism.@*Results@#The primary outcome is the difference in serum TSH levels between weekly and daily administration. Secondary outcomes included adverse events and clinical symptoms. The study included two randomized trials (n=109) in the primary analysis. The difference in TSH levels was 1.78 mIU/mL higher [(95% confidence interval (CI): 1.28 to 2.28, p<0.00001] at 6 weeks and 1.22 mIU/mL higher (95% CI: 0.76 to 1.67, p<0.00001) at 12 weeks for the weekly regimen. There was no significant heterogeneity between the two groups. There was no significant difference in hypothyroid symptoms and adverse events before and after levothyroxine treatment within each group.@*Conclusions@#Weekly levothyroxine resulted in less suppression and higher mean serum TSH levels, while still remaining within the normal reference range. It may be a suitable alternative for non-adherent patients. However, larger randomized trials with longer duration of follow-up are needed to firmly establish its role.

A Study of Nutritional Health Problems of Adolescent Girls in Rural Area of Nagpur District: A School Based Cross Sectional Study

Introduction: "Adolescence" literally means "to emerge"or "to attain identity" and is essentially the period of rapidphysical and psychological development. The World HealthOrganization (WHO) defines “adolescent” as an individualbetween 10 to 19 years of age. About 19.7% of Indianpopulation is adolescents. Nutritional health problems areone of the important health problem faced by adolescents.Prevalence of anemia in adolescents (15-19 years) girls is54%. Underweight is seen among 46.4% adolescent girls.Hence this study was conducted to find out nutritional healthproblems of adolescent girls in a rural area of Nagpur district.Menstrual hygiene was also studied.Material and methods: A cross sectional study was carriedout in one of the randomly selected school in a rural area ofNagpur. Calculated sample size was 145, though the studywas carried out on 150 adolescent girls in August 2019 usinga pre-designed and pre- tested questionnaire.Results: Mean age of study participants was 14.87± 2.77years. Prevalence of anemia was found to be 80%. Prevalenceof undernutrition was 36%. None of the student receivedweekly iron and folic acid tablets in last three months. Only28% study subjects received information of menstrual hygieneprior to menarche.Conclusion: Prevalence of anemia and undernutrition wasfound to be high in a school of rural area of Nagpur district.WIFS program should be strengthened through inter-sectoralcollaboration among health and education sectors

Reliability of Chinese Version of Weekly Calendar Planning Activity for an Executive Function Assessment in College Students / 中国康复理论与实践

Objective:To investigate the intrarater and interrater reliability of Chinese version of Weekly Calendar Planning Activity (WCPA-C) as evaluating the executive function in college students. Methods:From August to November, 2019, 55 college students aged 18 to 30 participated in this study. One rater evaluated all the subjects with WCPA-C and retested two weeks later. Two raters evaluated 31 of the subjects with WCPA-C. The intraclass correlation coefficient (ICC) was calculated for intrarater and interrater. Results:Two cases dropped out. The ICCs of the indexes were 0.45 to 0.89 for intrarater excepted Total Errors, and they were better from the second assessment than the first time. The ICC for interrater was 0.84 to 1.00. Conclusion:WCPA-C is well interrater reliable for the healthy college students in China, however, there may be learning effect as interval of two weeks.

Outcome of Chemotherapeutic Regimens Cisplatin and 5-Fluorouracil vs Weekly 5-Fluorouracil in Advanced Gastric Cancer

Introduction: Gastric cancer is the second leading cause ofcancer death worldwide, with a 5-year survival rate of lessthan 20%. About 25% of patients with gastric cancer presentwith disseminated disease and more than half of those withapparently localized disease recur within 5 years. Study aimedto evaluate the response rate, median PFS, overall survivaland toxicity to 3 Weekly Cisplatin/5-Fluorouracil Vs Weekly5-Fluorouracil in patients with advanced gastric cancer.Material and Methods: Patients were recruited forchemotherapy with Cisplatin 75mg/mg2 in divided dosesand 5-Fluorouracil 750mg/m2 for 3 days in every 21 daysfor 6 cycles in one arm and 20 patients for treatment withWeekly 5- Fluorouracil 500mg for 16 weeks. Within twomonths of completion of chemotherapy, CT abdomen wasdone to compare with the baseline CT abdomen to assess theresponse rate using RESIST criteria Version V1.1. Also theimprovement in ECOG PS was ascertained as an endpoint.Results: In the Cisplatin /5FU arm had an overall response rateof 20%, median PFS of 6 months,45% had a partial response(PR), 10% had stable disease (SD) 25% had progression(PD), 20% achieved CR and more of haematological andnon-hematological toxicity. In the 5FU arm, 35% had stabledisease (SD),40% had progression (PD) 5% achieved CR andless of haematological and non-hematological toxicity.Conclusion: In advanced gastric cancer, Cisplatin /5FU hadmore response rate, more median PFS and more toxicity.Weekly 5FU is better tolerable regimen with

Safety and efficacy in actual clinical practice of once-weekly subcutaneous teriparatide for osteoporosis patients with a high fracture risk

OBJECTIVES: To reassess the safety and efficacy of once-weekly teriparatide 56.5 mg in osteoporosis patients with a high fracture risk. METHODS: This postmarketing observational study was conducted at 72 weeks according to the package insert. Of the 3573 Japanese osteoporosis patients in the safety analysis set, 91.80% were women, the mean age was 78.1 years, and 69.89% had a history of prevalent fragility fractures, indicating that a high proportion of patients at high risk of fracture were enrolled. RESULTS: Persistence with weekly teriparatide treatment was 59.36%, and 38.95% at 24 and 72 weeks, respectively. Adverse drug reactions (ADRs) were reported in 898 patients (25.13%), and serious ADRs were reported in 26 patients (0.73%). The most frequent ADRs were nausea, vomiting, and headache. The cumulative incidence of new vertebral fractures 72 weeks after the start of treatment was 3.31%. Increases in the bone mineral density were observed in the lumbar spine, femoral neck, and proximal femur. The serum levels of the bone formation markers, procollagen type I N-terminal propeptide and bone-type alkaline phosphatase, increased slightly at 24 weeks and then decreased to baseline levels. At 24 and 72 weeks, the bone resorption markers, serum cross-linked N-terminal telopeptide of type I collagen and urinary cross-linked N-terminal telopeptide of type I collagen, were the same as or slightly lower than at baseline. Visual analogue scale scores for low back pain also decreased. CONCLUSIONS: The present results showed that once-weekly teriparatide may also be useful for osteoporosis patients with a high risk of fracture.

Utility of radius bone densitometry for the treatment of osteoporosis with once-weekly teriparatide therapy

OBJECTIVES: As clinics that treat patients with osteoporosis do not usually have central dual-energy X-ray absorptiometry (DXA), bone density is often measured with radial DXA. However, no long-term evidence exists for radius bone density outcomes following treatment with once-weekly teriparatide in actual medical treatment. METHODS: We evaluated changes in bone density at 6-, 12-, and 18-month intervals using radial DXA in patients treated with once-weekly teriparatide for more than 6 months. RESULTS: A significant increase in bone mineral density (BMD) was observed at the 1/3 and 1/10 radius sites 12 months after the initiation of once-weekly teriparatide. We also observed that the rate of change in BMD was greater at the distal 1/10 radius than at the 1/3 radius. CONCLUSIONS: Considering these points, the effect of once-weekly teriparatide therapy can be observed at the radius. In clinics that do not have central DXA, but instead have radial DXA, these findings can help to evaluate the effect of once-weekly teriparatide treatment on osteoporosis.

Application Effect of Weekly Maintenance Together for Detection Equipment by Persons Specifically Designated / 现代检验医学杂志

Objective To explore the application effect of weekly maintenance together for detection equipment by persons specifically designated.Methods Firstly carries on the preliminary training and the organization of the examination for all junior technicians and nurses,the appropriate persons were selected.Secondly,the recruited personnel were trained and as-sessed by the manufacturer or equipment engineers.After obtaining a certificate of conformity,weekly centralized mainte-nance for detection equipment officially began to implement in August 2014.Maintenance time was designated as every Wednesday afternoon or evening.Two months after the operation the test carried out by the head of clinical laboratory and the equipment department engineers in strict accordance with the week maintenance prcedures for each instrument and each item,and on-site questions.Other personnel also participated in the test as a control group.After half a year,the question-naire was sent to all the inspectors,and the satisfaction rate about the maintenance of the instrument was counted.Results Seven personnel selected to participate in the weekly maintenance,includings two senior technicians,three technicians and two nurses.Experimental personnel BC5390,UF-1000i,BH5100Plus and BH2100,C8000 and i2000,ADVIA2400 average score was significantly higher than the control group.Before and after the programme,the average number of failures of the instrument was reduced from 22 to 8 times and the average satisfaction rate of the inspection personnel was 83.0%±5.0%and 98.0%±2.0% respectively,and the difference was statistically significant.Conclusion Weekly centralized maintenance for detection equipment by persons specifically designated can truly implement instrument maintenance requirements,and at the same time with the implementation of the program,the failure times is greatly reduced,which is beneficial to improve the quality of inspection and to avoid the medical risks caused by TAT.

Once-weekly subcutaneous injection of recombinant human parathyroid hormone (1-34) promotes the bone fracture healing in rats / 中国实验动物学报

Objective To study the effect of once-weekly injection of recombinant human parathyroid hormone rhPTH(1-34) on the healing of bone fracture in rats.Methods Fifty male 3-month old SD rats were used in this study to produce unilateral tibial fracture and received internal fixation with a Kirschner needle.Based on the dose and frequency of rhPTH (1-34) injection, the rats were randomly divided into five groups (n=10 each) as follows: subcutaneous injec-tions of saline, and rhPTH in a dose of 10, 20, 10, and 20 μg/kg/d.After 4 weeks of treatment, the rats were euthana-tized and the fractured tibia were assessed by X-ray, dual energy X-ray absorptiometry ( DXA) ,micro-computed tomography ( microCT) and three-point bending test.Results The fracture healing in the 20μg/kg/w group was better than the saline group.The fracture healing in the 20μg/kg/w group was as well as the 10 μg/kg/dgroup.The BMD of 20μg/kg/w group was 26.2%higher than the saline group.The mineralized callus volume in the 20μg/kg/w group was 51.4%higher than the saline group.The total callus volume in the 20μg/kg/w group was 21.6%higher than the saline group.The ultimate load of the 20 μg/kg/w group was 29.3% higher than the saline group.There was no significant difference between the 20 μg/kg/w group and 10 μg/kg/d group in BMD, bone micro-architecture, and biomechanical strength ( P >0.05 ) . Conclusions Once weekly injection of rhPTH (1-34)can promote the bone fracture healing.

Pharmacist Education and National License Examination System in North Korea

Unity, understanding our pharmacist pharmacy education and training and their ecosystems rather then overwrite the system will get you ready to integrate and balance searching for contacts. Since 2015 we started the 6-year pharmacy education in the North were already carried out (the current 5.5 years). This chemist (or pharmacist) educate university education and vocational school and health officials made in the training school in jimyeo. Duration of each is to the University of 5.5 years, college three years, health officer training school two years and various types of training methods (weekly, communication, special) is applied is positive. License test system is also in favor of the state graduation test graduation test committee of professors in the university college diploma than the national notification system, and pharmacists 'qualifications'-are licensed is granted. The North Korean education system pharmacists and pharmacist review and analysis test system for the future reunification of Korea oriented education system pharmacists and pharmacists in health care personnel office systems through correct understanding and awareness-will be a useful resource integration plan designed to pharmacists.