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2.
MedUNAB ; 23(3): 423-433, 26/11/2020.
Article in Spanish | LILACS | ID: biblio-1141196

ABSTRACT

Introducción. El Síndrome de Burnout afecta mundialmente a más de 100,000,000 personas, con prevalencia entre 47 y 76% en médicos residentes. El objetivo de este trabajo fue determinar la relación entre el Síndrome de Burnout y los niveles de proteína C-reactiva ultrasensible en médicos residentes de un hospital universitario en Caracas, Venezuela. Metodología. Estudio transversal y descriptivo. El instrumento de recolección de datos, así como el test Maslach Burnout Inventory, fueron enviados en formato electrónico. Posteriormente, se seleccionó dos submuestras, a quienes se les determinó la concentración de proteína C-reactiva ultrasensible Resultados. La muestra inicial fue de 174 residentes, de los cuales 57 (32.8%) presentaban Burnout. Los residentes positivos para la presencia del síndrome tenían niveles más elevados de proteína C-reactiva ultrasensible (>0.50mg/dl) (р=0.001) con respecto al grupo sin Burnout. Igualmente, los residentes de género femenino (р=0.046), aquellos que dormían menos de 8 horas al día (р=0.032) y que estaban sometidos a estrés familiar (р=0.036) presentaron una asociación estadísticamente significativa para desarrollar el síndrome de bornout. Finalmente, se evidenció cómo los residentes de menor edad tenían mayores puntajes en la subescala despersonalización (p=0.036). Discusión. El estrés crónico (entre ellos el Síndrome de Bornout) puede activar de manera continua ejes fisiológicos estresores (hipotálamo-hipófisis- suprarrenal y simpático-adrenal); conllevando a la producción de citosinas y proteínas de fase aguda (como proteína C-reactiva ultrasensible), promoviendo un estado proinflamatorio en el individuo y el desarrollo de patologías crónicas. Conclusiones. El síndrome de bornout y las variables sociodemográficas/laborales representan una condición de estrés crónico que pueden asociarse entre sí y conducir al desarrollo de distintas enfermedades a largo plazo. Cómo citar. González-Moret YA, Guzmán Cuárez NE. Relación entre niveles de proteína c-reactiva y síndrome de burnout en médicos de postgrado. MedUNAB. 2020;23(3): 423-433. doi: https://doi.org/10.29375/01237047.3870


Introduction. Burnout Syndrome affects over 100,000,000 people worldwide, with a prevalence of between 47% and 76% in resident physicians. This project's objective is to determine the relationship between Burnout Syndrome and ultrasensitive C-reactive protein in resident physicians in a university hospital in Caracas, Venezuela. Methodology. Cross-sectional and descriptive study. The data collection tool, as well as Maslach Burnout Inventory test, were sent digitally. Two sub-samples were subsequently collected, whose concentration of us ultrasensitive C-reactive protein was determined. Results. The initial sample was 174 residents, of which 57 (32.8%) had Burnout. Residents who tested positive for the syndrome had higher levels of us-CRP (>0.50mg/dl) (р=0.001) with respect to the group without Burnout. Moreover, female residents (р=0.046), those who slept less than 8 hours every day (р=0.032) and those who were subject to family stress (р=0.036) demonstrated a statistically significant association with developing Burnout Syndrome. Finally, it was evident how younger residents had higher scores on the Depersonalization Subscale (p=0.036). Discussion. Chronic stress (among which is burnout syndrome) can continuously activate physiological stress axes (hypothalamic-pituitary-suprarenal and sympathetic-adrenal), which leads to producing cytosines and acute-phase proteins (such as ultrasensitive C-reactive protein), promoting a proinflammatory state in individuals and the development of chronic pathologies. Conclusion. Burnout Syndrome and sociodemographic/work variables represent a chronic stress condition and can be related to each other. They may lead to developing various long-term diseases. Cómo citar. González-Moret YA, Guzmán Cuárez NE. Relación entre niveles de proteína c-reactiva y síndrome de burnout en médicos de postgrado. MedUNAB. 2020;23(3): 423-433. doi: https://doi.org/10.29375/01237047.3870


Introdução. A Síndrome de Burnout afeta mais de 100 milhões de pessoas em todo o mundo, com uma prevalência de 47-76% em médicos residentes. O objetivo deste trabalho foi determinar a relação entre a síndrome de burnout e os níveis de proteína C-reativa ultrassensível em médicos residentes de um hospital universitário em Caracas, Venezuela. Metodologia. Trata-se de um estudo transversal e descritivo. O instrumento de coleta de dados, assim como o teste Maslach Burnout Inventory, foram enviados em formato eletrônico. Posteriormente, foram selecionadas duas subamostras, nas quais foi determinada a concentração de níveis de proteína C-reativa. Resultados. A amostra inicial foi de 174 residentes, dos quais 57 (32.8%) apresentaram Burnout. Os residentes positivos para a presença da síndrome apresentaram níveis mais elevados de níveis de proteína C-reativa (> 0.50mg/dl) (р = 0.001) em comparação com o grupo sem Burnout. Da mesma forma, residentes do sexo feminino (р = 0.046), aqueles que dormiam menos de 8 horas por dia (р = 0.032) e aqueles que foram submetidos a estresse familiar (р = 0.036) apresentaram uma associação estatisticamente significativa para o desenvolvimento da síndrome de burnou. Por fim, evidenciou-se que os residentes mais jovens apresentaram escores mais elevados na subescala de despersonalização (p = 0.036). Discussão. O estresse crônico (incluindo a síndrome de burnout) pode ativar continuamente os eixos fisiológicos dos estressores (hipotálamo-hipófise-suprarrenal e simpático-adrenal), levando à produção de citocinas e proteínas de fase aguda (como níveis de proteína C-reativa), promovendo um estado pró-inflamatório no indivíduo e o desenvolvimento de patologias crônicas. Conclusão. A síndrome de burnout e as variáveis sociodemográficas/laborais representam uma condição de estresse crônico que podem estar associadas entre si e levar ao desenvolvimento de diferentes doenças a longo prazo. Cómo citar. González-Moret YA, Guzmán Cuárez NE. Relación entre niveles de proteína c-reactiva y síndrome de burnout en médicos de postgrado. MedUNAB. 2020;23(3): 423-433. doi: https://doi.org/10.29375/01237047.3870


Subject(s)
Burnout, Professional , Acute-Phase Proteins , Cytokines , Depersonalization , Academic Medical Centers
3.
Ann. afr. méd. (En ligne) ; 13(4): 3861-3866, 2020. tab
Article in French | AIM | ID: biblio-1259098

ABSTRACT

Contexte et objectif. L'ampleur réelle des néphropathies congénitales est peu connue en Afrique et notamment en Guinée. L'objectif de cette étude était de déterminer la fréquence des néphropathies congénitales rencontrées. Méthodes. Cette étude documentaire de type descriptif sur la néphropathie congénitale, a été conduite entre les 1er janvier 2007 et 30 juin 2012, dans les services de pédiatrie et de chirurgie pédiatrique de Donka. Les paramètres d'intêret englobaient les données épidémiologiques, cliniques et paracliniques. Résultats. Parmi les 34.448 dossiers colligés, 26 présentaient une néphropathie congénitale. Il s'agissait des néphroblastomes (n=17), des syndromes de jonction pyélo-urétérale (n=6), d'une hydronéphrose sur rein multikystique gauche (n=1), d'un rein multikystique en ptose (n=1) et d'une ectopie rénale (n=1). Le sexe masculin était prépondérant (21/26) avec un sexe ratio de 4,2/1. Les enfants de 29 jours à 2 ans étaient les plus touchés. Conclusion. Les néphropathies congénitales sont paraissent moins fréquentes dans cette institution hospitalière, à cause du manque d'un plateau technique diagnostique optimal. Le diagnostic précoce des néphropathies congénitales devrait être fait dans la période prénatale ce qui permettrait une meilleure prise en charge des enfants affectés


Subject(s)
Academic Medical Centers , Guinea , Kidney Diseases/diagnosis , Kidney Diseases/epidemiology , Multicystic Dysplastic Kidney , Wilms Tumor
4.
Niger. J. Dent. Res ; 5(2): 136-144, 2020. ilus
Article in English | AIM | ID: biblio-1266998

ABSTRACT

Objective: Full complement and replacement of lost teeth improves oral health and quality of life. The objective of this study was to assess the level of awareness of factors that can prevent premature loss of teeth and the reason for non-replacement of missing/lost teeth among nurses in a tertiary health institution. Methods: This study was a descriptive cross-sectional study, 251 nurses of the Jos University Teaching Hospital participated. Self-administered questionnaires were used for data collection. Analysis of data was done with IBM SPSS version 23.0. Results: The mean age of the 251 nurses was 38±9.88. 174(69.3%) were females while 77(30.7%) were males. Out of 91(36.3%) that had missing teeth, 16(17.6%) actually replaced their missing teeth with the majority of them representing 81.3% adopting removable acrylic partial denture as modality. Among the 75(82.4%) that did not replace their missing teeth, the reason for the non-replacement by the majority- 40.0% was that they didn't feel replacement was necessary. Conclusion: The awareness level on factors that can prevent premature loss of teeth was observed to be high among the participants, but many have missing teeth that needed replacement. Majority did not replace their missing teeth as a result of low level of awareness of the consequences and probably due to financial challenges and because of the non-coverage of prosthetic treatments by the National Health Insurance Scheme 'NHIS' in Nigeria


Subject(s)
Academic Medical Centers , Denture, Partial, Removable , Nigeria , Nurses , Oral Health , Quality of Life , Replantation , Tooth Loss
5.
Article in English | WPRIM | ID: wpr-719626

ABSTRACT

PURPOSE: To characterize the population of hypogonadal men who presented to a tertiary academic urology clinic and evaluate risk factors for primary vs. secondary hypogonadism. MATERIALS AND METHODS: We evaluated all men with International Classification of Diseases-9 diagnosis codes R68.82 and 799.81 for low libido, 257.2 for testicular hypofunction, and E29.1 for other testicular hypofunction at a tertiary academic medical center from 2013 to 2017. We included men who had testosterone (T) and luteinizing hormone (LH) drawn on the same day. We classified men based on T and LH levels into eugonadal, primary, secondary, and compensated hypogonadism. Risk factors including age, body mass index (BMI) over 30 kg/m2, current smoking status, alcohol use greater than 5 days per week, and Charlson comorbidity index greater than or equal to 1 were investigated and measured in each group using the eugonadal group for reference. RESULTS: Among the 231 men who had both T and LH levels, 7.4%, 42.4%, and 7.4% were classified as primary, secondary, and compensated hypogonadism, respectively. Only elevated BMI was associated with secondary hypogonadism compared to eugonadal men (median BMI, 30.93 kg/m2 vs. 27.69 kg/m2, p=0.003). BMI, age, comorbidities, smoking, or alcohol use did not appear to predict diagnosis of secondary hypogonadism. CONCLUSIONS: Secondary hypogonadism appears to be the most common cause of hypogonadism among men complaining of low T and decreased libido at a tertiary academic medical center. Secondary hypogonadism is associated with elevated BMI and therefore obesity should be used as a marker to evaluate men for both T and LH levels.


Subject(s)
Academic Medical Centers , Body Mass Index , Classification , Clomiphene , Comorbidity , Diagnosis , Humans , Hypogonadism , Libido , Luteinizing Hormone , Male , Obesity , Risk Factors , Smoke , Smoking , Tertiary Care Centers , Testosterone , Urology
6.
Article in Korean | WPRIM | ID: wpr-719439

ABSTRACT

BACKGROUND/AIMS: The eradication of Helicobacter pylori (H. pylori) is an effective treatment in gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with H. pylori infection. However, the treatment strategy in gastric MALT lymphoma patients who are H. pylori-negative or unresponsive to H. pylori eradication therapy remains controversial. In this study, we investigated the clinical efficacy of treatments other than H. pylori eradication therapy in these groups of patients. METHODS: This was a retrospective single-center study based on the medical records of patients diagnosed with gastric MALT lymphoma at Yeungnam University Medical Center between January 2005 and December 2016. Patients were treated with H. pylori eradication therapy, chemotherapy, or radiotherapy according to their H. pylori infection status and stage of gastric MALT lymphoma. RESULTS: Of the 68 eligible patients, 50 were enrolled in the study. Of the 42 patients with H. pylori-positive gastric MALT lymphoma, 36 (81.7%) were treated with H. pylori eradication therapy as primary treatment and 25 (69.4%) achieved a complete response (CR). Patients without a CR after H. pylori eradication therapy (n=11, 30.6%) received radiotherapy as a secondary treatment. Two patients with H. pylori-positive gastric MALT lymphoma and eight with H. pylori-negative gastric MALT lymphoma received radiotherapy as the primary treatment. CR was achieved in all 21 patients treated with radiotherapy as primary or secondary treatment. The 5-year progression-free survival rate after radiotherapy was 92.9%. CONCLUSIONS: Radiotherapy may be a worthwhile treatment option in patients with H. pylori-negative MALT lymphoma or H. pylori-positive MALT lymphoma that is not responsive to H. pylori eradication therapy.


Subject(s)
Academic Medical Centers , Disease-Free Survival , Drug Therapy , Helicobacter pylori , Helicobacter , Humans , Lymphoid Tissue , Lymphoma , Lymphoma, B-Cell, Marginal Zone , Medical Records , Radiotherapy , Retrospective Studies , Stomach Neoplasms , Treatment Outcome
7.
Gut and Liver ; : 54-61, 2019.
Article in English | WPRIM | ID: wpr-719367

ABSTRACT

BACKGROUND/AIMS: Statins have been postulated to lower the risk of colorectal neoplasia. No studies have examined any possible chemopreventive effect of statins in patients with inflammatory bowel disease (IBD) undergoing colorectal cancer (CRC) surveillance. This study examined the association of statin exposure with dysplasia and CRC in patients with IBD undergoing dysplasia surveillance colonoscopies. METHODS: A cohort of patients with IBD undergoing colonoscopic surveillance for dysplasia and CRC at a single academic medical center were studied. The inclusion criteria were IBD involving the colon for 8 years (or any colitis duration if associated with primary sclerosing cholangitis [PSC]) and at least two colonoscopic surveillance exams. The exclusion criteria were CRC or high-grade dysplasia (HGD) prior to or at enrollment, prior colectomy, or limited ( < 30%) colonic disease. The primary outcome was the frequency of dysplasia and/or CRC in statin-exposed versus nonexposed patients. RESULTS: A total of 642 patients met the inclusion criteria (57 statin-exposed and 585 nonexposed). The statin-exposed group had a longer IBD duration, longer follow-up period, and more colonoscopies but lower inflammatory scores, less frequent PSC and less use of thiopurines and biologics. There were no differences in low-grade dysplasia, HGD, or CRC development during the follow-up period between the statin-exposed and nonexposed groups (21.1%, 5.3%, 1.8% vs 19.2%, 2.9%, 2.9%, respectively). Propensity score analysis did not alter the overall findings. CONCLUSIONS: In IBD patients undergoing surveillance colonoscopies, statin use was not associated with reduced dysplasia or CRC rates. The role of statins as chemopreventive agents in IBD remains controversial.


Subject(s)
Academic Medical Centers , Biological Products , Chemoprevention , Cholangitis, Sclerosing , Cohort Studies , Colectomy , Colitis , Colon , Colonic Diseases , Colonoscopy , Colorectal Neoplasms , Epidemiology , Follow-Up Studies , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Inflammatory Bowel Diseases , Prevalence , Propensity Score
8.
Yonsei Medical Journal ; : 223-229, 2019.
Article in English | WPRIM | ID: wpr-742515

ABSTRACT

PURPOSE: To investigate the overall cancer risk and risk for specific cancers in rheumatoid arthritis (RA) patients in Korea by comparing cancer incidence between RA patients and the general population. MATERIALS AND METHODS: Individuals diagnosed with RA between 1996 and 2009 who underwent treatment at the Daegu Catholic University Medical Center were retrospectively examined. 1885 patients with RA were included in the analyses. Occurrence of cancer and death during follow up was ascertained by linking medical records to the Korean Central Cancer Registry and national death certificates. For comparing cancer incidence between RA patients and general population, standardized incidence ratios (SIR) were calculated. The 95% confidence intervals (CIs) of SIRs were calculated using the shortcut method introduced by Vandenbroucke. RESULTS: The total follow-up time was 10218.9 person-years. During follow up, 100 patients (31 men and 69 women) were diagnosed with cancer. Both men and women had greater risks of having malignancy, although cancer risk was greater in men. Men showed increased risks of lung cancer (SIR=5.46, 95% CI: 2.60–9.36) and leukemia (SIR=16.7, 95% CI: 1.58–47.9). Women showed increased risks of thyroid cancer (SIR=1.75, 95% CI: 1.02–2.68), cervical cancer (SIR=3.65, 95% CI: 1.65–6.42), non-Hodgkin's lymphoma (SIR=6.47, 95% CI: 2.04–13.4), and gallbladder cancer (SIR=3.87, 95% CI: 1.01–8.60). Disease-modifying anti-rheumatic drugs usage and cancer were not related: the relative risks of developing malignancy were not elevated for each medicine. CONCLUSION: The overall cancer incidence was increased in Korean men and women with RA. Increased risk of specific malignancy differed according to sex.


Subject(s)
Academic Medical Centers , Antirheumatic Agents , Arthritis, Rheumatoid , Death Certificates , Female , Follow-Up Studies , Gallbladder Neoplasms , Humans , Incidence , Korea , Leukemia , Lung Neoplasms , Lymphoma, Non-Hodgkin , Male , Medical Records , Methods , Retrospective Studies , Thyroid Neoplasms , Uterine Cervical Neoplasms
9.
Article in English | WPRIM | ID: wpr-742146

ABSTRACT

BACKGROUND/AIMS: Surgical resection or ablation is recommended for the treatment of early hepatocellular carcinoma (HCC), whereas transarterial chemoembolization (TACE) is frequently used in early HCC ineligible for curative resection. We evaluated the clinical effects and safety of radiofrequency ablation (RFA) shortly after TACE in patients with Barcelona clinic liver cancer (BCLC) stage A HCC. METHODS: Sixty-seven BCLC stage A HCC patients who failed to achieve complete response to TACE as either a first line treatment and who subsequently received RFA at the Konkuk University Medical Center from January 2005 to December 2017 were included. Evaluation indices included treatment response, overall survival rate, recurrence-free survival, prognostic factors, and procedure-related complications. RESULTS: Median follow-up was 46.9 months. Fifty-four (80.6%) patients were of Child-Pugh class A, and 13 (19.4%) were of class B. Modified UICC stages were I in 10 (14.9%), II in 46 (68.7%), and III in 11 (16.4%) patients. In the 67 study subjects, cumulative recurrence-free survival rates were 86.8%, 55.9% and 29.7% at 1, 3, and 5 years, respectively, and overall survival rates were 100%, 93.4%, and 83.5% at 1, 3, and 5 years, respectively. Tumor size significantly predicted recurrence. No treatment-related death occurred. CONCLUSIONS: Combination of RFA was an efficient and safe treatment for BCLC stage A HCC patients that failed to achieve complete response to initial TACE. We suggest TACE plus RFA be considered as a curative option for early HCC patients ineligible for curative resection of RFA.


Subject(s)
Academic Medical Centers , Carcinoma, Hepatocellular , Catheter Ablation , Follow-Up Studies , Humans , Liver Neoplasms , Liver , Recurrence , Survival Rate , Treatment Outcome
10.
Journal of Stroke ; : 332-339, 2019.
Article in English | WPRIM | ID: wpr-766258

ABSTRACT

BACKGROUND AND PURPOSE: To investigate the number and characteristics of patients eligible for endovascular treatment (EVT) determined using three different selection methods: clinical-core mismatch, target mismatch, and collateral status. METHODS: Using the data of consecutive patients from two prospectively maintained registries of university medical centers, the number and characteristics of patients according to the three selection methods were investigated and their correlation was analyzed. Patients with anterior circulation stroke due to occlusion of the middle cerebral and/or internal carotid artery and a National Institute of Health Stroke Scale (NIHSS) score of ≥6 points, who arrived within 8 hours or between 6 and 12 hours of symptom onset and underwent magnetic resonance imaging prior to EVT, were included. Collateral status was assessed using magnetic resonance perfusion-derived collateral flow maps. RESULTS: Three hundred thirty-five patients were investigated; the proportions of patients who were eligible and ineligible for EVT in all three selection methods were both small (n=85, 25.4%; n=54, 16.1%, respectively). The intercorrelation among the three selection methods was low (κ=0.235). The baseline NIHSS score and onset-to-selection time interval were associated with the presence of clinical-core mismatch, while the penumbra/core volume ratio and onset-to-selection time interval were related to target mismatch; none of these variables were associated with collateral status. The infarct core volume was associated with favorable profiles in all three selection methods. CONCLUSIONS: Although the application of individual selection methods resulted in favorable outcomes after EVT in clinical trials, there is a significant discrepancy in EVT eligibility depending on the selection method used.


Subject(s)
Academic Medical Centers , Carotid Artery, Internal , Humans , Magnetic Resonance Imaging , Methods , Prospective Studies , Registries , Stroke
11.
Article in English | WPRIM | ID: wpr-766181

ABSTRACT

OBJECTIVE: Our aim was to investigate the long term safety and efficacy of etanercept in children with juvenile idiopathic arthritis (JIA). METHODS: The study subjects were the 90 JIA patients treated with etanercept in the Department of Pediatrics, Hallym University Medical Center between January 2004 and December 2017. We retrospectively reviewed their medical records for age at diagnosis, duration of etanercept treatment, number of active joints, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and adverse events during treatment. RESULTS: Among the 90 patients, 38 (42.0%) were male and 52 (58.0%) were female; 15 (16.7%) had systemic onset, 41 (45.6%) had extended oligoarticular, 14 (15.6%) had rheumatoid factor-positive polyarticular, 18 (20.0%) had rheumatoid factor-negative polyarticular, and 2 (2.1%) had enthesitis-related arthritis. The median age at the start of etanercept treatment was 9 years (range, 3~18 years), and the median duration of etanercept treatment was 6 years (range, 0.5~13 years). The median number of active joints decreased from 9 to 0 after 6 months of etanercept treatment. The median CRP and ESR were within normal range after 3 months of treatment. Six patients experienced recurrence, 9 switched to other medications and 3 discontinued etanercept. Of the 14 reported adverse events, 1 was serious, and there were no tuberculosis infections or malignancies. CONCLUSION: Long-term treatment with etanercept is efficacious and safe for children with JIA. However, those with the systemic onset subtype appear to have low drug survival rate compared to those with other types of JIA.


Subject(s)
Academic Medical Centers , Arthritis , Arthritis, Juvenile , Blood Sedimentation , C-Reactive Protein , Child , Diagnosis , Etanercept , Female , Humans , Joints , Male , Medical Records , Pediatrics , Recurrence , Reference Values , Retrospective Studies , Survival Rate , Tuberculosis
12.
Article in English | WPRIM | ID: wpr-765394

ABSTRACT

OBJECTIVE: Rheumatoid arthritis (RA) is known to involve the cervical spine up to 86%. It often causes cervical instability like atlantoaxial subluxation (AAS), subaxial subluxation, and vertical subluxation (VS). In order to find the relation between RA and cord compression, we will evaluate the characteristics and risk factors of basilar invagination (BI) and cervicomedullary junction (CMJ) compression. METHODS: From January 2007 to May 2015, 12667 patients administrated to Hanyang University Medical Center. Four thousand three hundred eighty-six patients took cervical X-ray and 250 patients took cervical computed tomography or magnetic resonance imaging. Radiologic parameters, medication records were obtained from 242 patients. Multivariate logistic regression analysis was performed with correlation of CMJ compression, basin-dental interval (BDI), basin-posterior axial line interval (BAI), pannus formation, BI, and AAS. RESULTS: In the point of CMJ compression, atlantodental interval (ADI), posterior-atlantodental interval, BAI, AAS, and BI are relatively highly correlated. Patients with BI have 82 times strong possibility of radiologic confirmed CMJ compression, while AAS has 6-fold and pannus formation has the 3-fold possibility. Compared to the low incidence of BI, AAS and pannus formation have more proportion in CMJ compression. Furthermore, wrist joint erosion was correlated with VS and AAS. CONCLUSION: BI has a very strong possibility of CMJ compression, while AAS and pannus formation have a high proportion in CMJ compression. Hence bilateral wrist joint erosion can be used as an indicator for the timing of screening test for cervical involvement. We suggest the early recommendation of cervical spine examination for the diagnosis of cervical involvement in order to prevent morbidity and mortality.


Subject(s)
Academic Medical Centers , Arthritis, Rheumatoid , Diagnosis , Humans , Incidence , Logistic Models , Magnetic Resonance Imaging , Mass Screening , Mortality , Risk Factors , Spine , Wrist Joint
13.
Clinical Endoscopy ; : 175-181, 2019.
Article in English | WPRIM | ID: wpr-763411

ABSTRACT

BACKGROUND/AIMS: The aim of this study was to describe the diagnostic yield of endoscopic ultrasound (EUS) in patients with isolated elevated levels of amylase and/or lipase. METHODS: A retrospective chart review was conducted at a large academic medical center from 2000 to 2016. Patients were selected based on having elevated amylase, lipase, or both, but without a diagnosis of pancreatitis or known pancreatobiliary disease. Patients were excluded if they had abnormal liver function tests or abnormal imaging of the pancreas. RESULTS: Of 299 EUS procedures performed, 38 met inclusion criteria. Symptoms were present in 31 patients, most frequently abdominal pain (87%). In 20 patients (53%), initial EUS most commonly found chronic pancreatitis (n=7; 18%), sludge (5; 13%), or new diagnosis of pancreas divisum (3; 8%). In the asymptomatic patients (7), 3 had a finding on EUS, most importantly sludge (2), stone (1), and pancreas divisum (1). No patients were diagnosed with a mass or pancreatic cyst. During the follow up period, 6 patients (22%) had cholecystectomy. CONCLUSIONS: In our study of patients with isolated elevations in amylase and/or lipase without acute pancreatitis who underwent EUS, approximately 50% had a pancreatobiliary finding, most commonly chronic pancreatitis or biliary sludge.


Subject(s)
Abdominal Pain , Academic Medical Centers , Amylases , Bile , Cholecystectomy , Diagnosis , Endosonography , Follow-Up Studies , Humans , Lipase , Liver Function Tests , Pancreas , Pancreatic Cyst , Pancreatitis , Pancreatitis, Chronic , Retrospective Studies , Sewage , Ultrasonography
14.
Article in English | WPRIM | ID: wpr-762698

ABSTRACT

PURPOSE: The purpose of this study was to investigate the prevalence of postthyroidectomy obesity, and the relationship between the extent of thyroidectomy and obesity. METHODS: A survey conducted at an outpatient clinic from June to October 2014 and retrospective charts for patients undergoing thyroidectomy at Konkuk University Medical Centers from June 2009 to December 2013 were reviewed. We compared clinical characteristics and pre- and postoperative obesity-related factors in 227 patients who underwent total thyroidectomy or lobectomy. RESULTS: Patients included 39 males and 188 females with a mean age of 46.0 ± 11.0 years; the mean follow-up period was 23.9 ± 16.7 months, and 90 of the 227 patients showed postthyroidectomy obesity. In effect of operative extent on postoperative obesity, patients who underwent TT (48.2 years) than those who underwent lobectomy (43.4 years). TT group had longer follow-up and the frequency of menopause was higher than in the lobectomy group. No differences in postthyroidectomy obesity, body weight change, or body mass index (BMI), change among 2 groups. The predictors of postthyroidectomy obesity were older age, female, heavy alcohol consumption (P = 0.029), higher preoperative BMI (P < 0.001), larger postoperative weight gain (P = 0.024), and larger BMI change. However, the extent of thyroidectomy did not affect postthyroidectomy obesity. Preoperative BMI (P < 0.001) and heavy alcohol consumption (P = 0.03) were independent factors of postthyroidectomy obesity. CONCLUSION: The extent of thyroidectomy does not affect postthyroidectomy obesity. Preoperative BMI and heavy alcohol consumption are risk factors for postthyroidectomy obesity. Studies are needed to suggest preoperative life style modification to prevent postthyroidectomy obesity.


Subject(s)
Academic Medical Centers , Alcohol Drinking , Ambulatory Care Facilities , Body Mass Index , Body Weight Changes , Female , Follow-Up Studies , Humans , Life Style , Male , Menopause , Obesity , Prevalence , Retrospective Studies , Risk Factors , Thyroid Neoplasms , Thyroidectomy , Weight Gain
16.
Article in French | AIM | ID: biblio-1263854

ABSTRACT

Introduction : les pathologies allergiques constituent un problème de santé publique. Les acarienssont des pneumallergènes responsables des rhinites allergiques et des crises d'asthme. Aucun travail spécifique sur la sensibilisation aux acariens chez les enfants n'a été réalisé au Togo. La présente étude avait pour objectif d'analyser le profil et les facteurs associés à la sensibilisation aux acariens chez les enfants consultant dans l'unité de pneumo-allergologie du CHU Campus de Lomé. Patients et méthodes : ils'agissait d'une étude prospective et descriptive réalisée du 1er janvier 2015 au 31 décembre 2017 dans l'unité de pneumo-allergologie du CHU-Campus de Lomé. Etaient inclus dans cette étude, les enfants âgés de zéro à 18 ans ayant consulté dans l'unité de pneumo-allergologie et qui après acceptation et réalisation des tests cutanés étaient sensibilisés aux acariens. Les paramètres étudiés étaient les données sociodémographiques, l'environnement domestique, les données cliniques et les résultats des prick-tests. L'analyse des données a été faite avec Epidata 3.1. Résultats : durant la période d'étude, la fréquence de sensibilisation aux acariens était de 82,9%. L'âge moyen des enfants était de 8 +/- 5,1 ans. Il y avait une prédominance féminine avec une sexe ratio de 0,88. Le principal motif de consultation était la rhinite. Près de sept enfants sur dix vivaient dans des habitats anciens (67,5%), situés à proximité d'une route non bitumée (68,6%) et cohabitaient avec des animaux en particulier le chien (23%). Les différents types d'acariens rencontrés chez les enfants après prick-test étaient le Dermatophagoides Ptéronyssinus, le Dermatophagoides farinae et le Blomia tropicalis. Conclusion : la sensibilisation aux acariens chez les enfants est élevée et il faudrait accentuer l'information sur les mesures de prévention


Subject(s)
Academic Medical Centers , Acari , Allergy and Immunology , Immunization , Office Visits , Togo
17.
Article in French | AIM | ID: biblio-1263857

ABSTRACT

Introduction : l'hépatite aiguë est fréquente et représente un problème de santé publique dans les pays en développement. Les étiologies sont dominées par l'hépatite A en Afrique subsaharienne et en Asie du Sud-Est. Cependant, très peu d'études locales ont porté sur cette pathologie. Objectif : Étudier les aspects épidémiologiques, cliniques et évolutifs des hépatites aiguës chez les enfants hospitalisés au CHNEAR. Matériel et Méthodes : il s'agissait d'une étude rétrospective réalisée au CHNEAR de Dakar du 1er janvier 2007 au 31 décembre 2017. Étaient inclus les enfants hospitalisés pour une hépatite aiguë. Les données socio démographiques, cliniques, paracliniques et évolutives ont été recueillies. L'analyse des données uni et bivariée était faite grâce au logiciel R studio version 3.5.0. Résultats : au total, 35 000 enfants étaient hospitalisés durant la période d'étude parmi lesquels 71 patients avaient une hépatite aiguë déterminant une prévalence hospitalière de 0,2%. L'âge moyen à l'admission était de 65 mois avec un sex-ratio de 1,5. L'ictère cutanéo-muqueux était le principal signe physique (81,7%). La cytolyse était constante avec une moyenne des ALAT de 549UI/L. Une insuffisance hépatocellulaire était notée chez 24% des patients. L'étiologie était dans la grande majorité des cas indéterminée (66,2%). L'hépatite A représentait 15,5% et la phytothérapie (18,3%). L'évolution était favorable dans l'ensemble sans aucun cas de rechute. La létalité était de 16,9%. Conclusion : l'étiologie des hépatites demeurent encore indéterminées dans une large proportion au CHNEAR de Dakar. Le pronostic reste réservé pour les formes graves avec insuffisance hépatocellulaire


Subject(s)
Academic Medical Centers , Child , Disease Progression , Hepatitis A/diagnosis , Hepatitis A/epidemiology , Hepatitis A/etiology , Hepatitis, Viral, Human , Senegal
18.
Article in French | AIM | ID: biblio-1263858

ABSTRACT

Introduction : l'échec thérapeutique rapporté dans diverses études est une difficulté inhérente au traitement antirétroviral au long cours. L'objectif dans cette étude était de déterminer les facteurs associés à l'échec thérapeutique chez les enfants au CNHU-HKM de Cotonou afin d'améliorer leur prise en charge. Méthodes : il s'agissait d'une étude transversale couvrant la période du 1er septembre 2014 au 31 août 2015. Les données (caractéristiques socio-démographiques, cliniques et immuno-virologiques, thérapeutique, observance) de 44 enfants en échec thérapeutique avaient été comparées à celles de 136 enfants en succès thérapeutique. La comparaison des proportions était faite avec le test du Chi 2. L'association était significative lorsque p était inférieur à 0,05. Résultats : la prévalence de l'échec thérapeutique était de 24,4%. Les enfants en échec étaient des adolescents dans 56,8 % des cas. Les facteurs significativement associés à l'échec thérapeutique après analyse multivariée étaient la mauvaise observance (p<0,0001 OR 14,19), la survenue de comorbidité comme la tuberculose (p=0,003 OR 7,97), les schémas thérapeutiques complexes (p=0,016 OR 0,17) et les substitutions de molécules plus de deux fois dans la même ligne thérapeutique (p<0,0001 OR 0,038). Conclusion : il est nécessaire d'établir des procédures de gestion des adolescents permettant une annonce du statut assez tôt et les prescriptions d'ARV doivent être simples


Subject(s)
Academic Medical Centers , Benin , Treatment Failure
19.
Article in English | AIM | ID: biblio-1263859

ABSTRACT

Introduction : l'incidence de la bronchiolite est en augmentation constante dans notre hôpital. De multiples études ont été effectuées sur les molécules à utiliser pour l'aérosolthérapie pour améliorer la prise en charge de la bronchiolite. L'objectif de cette étude était de comparer l'efficacité du SSH 3% versus salbutamol et adrénaline. Méthodes : il s'agissait d'une étude comparative menée sur une période de sept mois au Centre Hospitalier Universitaire Mère Enfant Ambohimiandra, incluant tous les nourrissons de 29 jrs à deux ans admis pour bronchiolite. Les aérosols ont été effectués tous les 3 heures pour chaque groupe de population. L'efficacité de chaque molécule à partir des scores cliniques de Wang et RDAI, la fréquence cardiaque, et la SaO2 ont été évaluées. Résultats : au total 122 nourrissons ont été inclus. 60 avaient moins de trois mois dont 30 étaient sous SSH 3 % et 30 sous adrénaline, 62 avaient plus de trois mois dont 31 étaient sous SSH 3% et 31 sous salbutamol. Une amélioration nette du score clinique RDAI dès la H12 (p=0.01), de la fréquence cardiaque dès la H24 (p=0.01), et de la SaO2 dès la H1 (p=0,004) ont été observé chez les nourrissons moins de trois mois sous SSH 3%. Il n'y pas eu de différence avec celui du salbutamol Conclusion : la SSH 3% était plus efficace que l'adrénaline dans le traitement de la bronchiolite aigue chez les nourrissons moins de trois mois


Subject(s)
Academic Medical Centers , Albuterol , Bronchiolitis , Epinephrine , Infant , Madagascar
20.
Article in French | AIM | ID: biblio-1263860

ABSTRACT

Introduction : la transmission verticale du virus de l'hépatite B (VHB) peut être prévenue par la vaccination et l'administration précoce d'immunoglobuline spécifiques anti-HBs. En Côte d'Ivoire, seule la vaccination est faite à la sixième semaine de vie dans le cadre du programme élargi de vaccination (PEV). L'objectif de ce travail était d'étudier la réponse vaccinale du nouveau-né après vaccination précoce à la naissance. Patients et méthodes : une étude prospective longitudinale à visée descriptive et analytique conduite du 1er octobre 2016 au 31 octobre 2017 au CHU de Cocody. Toutes les parturientes admises en salle d'accouchement du CHU de Cocody, ont été dépistées au VHB. Les nouveau-nés de mères Ag HBs positif, qui ont reçu quatre doses de vaccin contre le VHB ont été inclus. Résultats : pendant la période d'étude 1668 femmes ont été dépistées au VHB. Celles qui étaient positives au VHB étaient 5,57 %. Les nouveau-nés retenus étaient au nombre de 45. Leurs mères avaient une charge virale moyenne de 8 217 417Ul/ml et elles avaient accouché par voie basse dans 76% des cas. Ces nouveau-nés étaient nés à terme (97,8%) et présentaient à neuf mois de vie un taux moyen d'Ac antiHBs de 437,2 UI/ml. Ils étaient immunisés contre le VHB dans 89% des cas. Il avait été noté 2,2 % d'infection. La charge virale élevée chez la mère était statistiquement liée à la non-réponse vaccinale (p=0,010). Conclusion : la vaccination contre le VHB débutée précocement, prévient l'infection périnatale du VHB et confère une immunité contre le VHB


Subject(s)
Academic Medical Centers , Cote d'Ivoire , Disease Management , Hepatitis B/diagnosis , Infant, Newborn
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