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J. pediatr. (Rio J.) ; 98(1): 104-110, Jan.-Feb. 2022. tab, graf
Article in English | LILACS | ID: biblio-1360562


Abstract Objective: To estimate the prevalence and factors associated with overweight/obesity development in adolescents with early diagnosed phenylketonuria treated exclusively by diet. Methodology: In this cross-sectional study anthropometric measurements, serum phenylalanine levels, and 10 metabolites associated with lipid and carbohydrate metabolism were analyzed in 101 adolescents aged 10-20 years. Adolescents were categorized into overweight/obesity and eutrophic/low body mass index groups. These patients were compared using Student's t-test, Pearson's chi-square test, Wald's chi-square test for multivariate analysis. Further, to verify whether the prevalence of overweight/obesity found in the study population was similar to that in the general population, the authors compared the nutritional status of 46 patients aged 13-17 years with that of healthy students of the same age from the National School Health Survey using the chi-square test for adherence. The significance threshold was p < 0.5. Results: The prevalence of overweight/obesity in adolescents was 27.7%. There was no difference in prevalence between sexes. Older age was a protective factor and Increased Homeostasis Model Assessment Insulin Resistance index and high phenylalanine and low-density lipoprotein cholesterol levels were predictive factors for overweight/obesity. The equality hypothesis was not rejected in the comparison of nutritional states of 46 patients aged 13-17 years and healthy students of the same age. Conclusion: The prevalence of overweight/obesity in phenylketonuria adolescents was similar to what is found in healthy adolescents.

Humans , Child , Adolescent , Adult , Young Adult , Phenylketonurias/complications , Phenylketonurias/epidemiology , Pediatric Obesity/complications , Pediatric Obesity/epidemiology , Body Mass Index , Prevalence , Cross-Sectional Studies , Causality , Overweight/complications , Overweight/diagnosis , Overweight/epidemiology
Rev. bras. ginecol. obstet ; 43(11): 834-839, Nov. 2021. tab, graf
Article in English | LILACS | ID: biblio-1357075


Abstract Objective It has been suggested that excess body weight could represent a risk factor for infertility outcomes. The present study aimed to evaluate the association of overweight and anovulation among infertile women with regular menstrual cycles. Methods We conducted a retrospective case-control study with consistently anovulatory patients undergoing assisted reproduction treatment. The patients were stratified into normal weight (body mass index [BMI]: 18.5-24.9kg/m2) and overweight (BMI: 25.0- 29.9kg/m2).Those with polycystic ovary syndrome or obesity were excluded. The groups were matched for age, duration of infertility, prolactin, follicle stimulating hormone (FSH), thydroid stimulating hormone (TSH), luteinizing hormone (LH), and estradiol levels. Results Overweight was significantly associated with anovulation, when using the World Health Organization (WHO) criteria for anovulation: progesterone levels>5.65 ng/ml and ultrasonography evidence of follicle collapse (odds ratio [OR]: 2.69; 95% confidence interval [CI95%]: 1.04-6.98). Conclusion Body mass index above the normal range jeopardizes ovulation among non-obese infertile women with regular menstrual cycles.

Resumo Objetivo O excesso de peso corporal tem sido associado como fator de risco para infertilidade. Este estudo teve como objetivo avaliar a associação de sobrepeso e anovulação entre mulheres inférteis com ciclos menstruais regulares. Métodos Realizamos um estudo retrospectivo de caso-controle com mulheres com anovulação consistente em tratamento por reprodução assistida. As pacientes foram estratificadas entre aquelas com peso normal (índice de massa corporal [IMC]: 18,5- 24,9 Kg/m2) e as com sobrepeso (IMC: 25,0-29,9 Kg/m2). As pacientes com síndrome do ovário policístico ou obesidade foram excluídas. Os grupos foram pareados por idade, duração da infertilidade, níveis de prolactina, hormônio folículo-estimulante (FSH), hormônio tiroestimulante (TSH), hormônio luteinizante (LH) e estradiol. Resultados O excesso de peso associou-se significativamente à anovulaçãoquando usados os critérios de anovulação da Organização Mundial de Saúde (OMS): níveis de progesterona>5,65 ng/ml e evidência ultrassonográfica de colapso folicular (razão de chances [RC]: 2,69; IC95%: 1,04-6,98). Conclusão O IMC acima da faixa normal compromete a ovulação em mulheres inférteis não obesas com ciclos menstruais regulares.

Humans , Female , Polycystic Ovary Syndrome/complications , Infertility, Female/complications , Anovulation/complications , Case-Control Studies , Retrospective Studies , Overweight/complications , Follicle Stimulating Hormone , Menstrual Cycle
Arch. endocrinol. metab. (Online) ; 65(4): 462-467, July-Aug. 2021. tab
Article in English | LILACS | ID: biblio-1339106


ABSTRACT Objective: Describe the demographic, clinical, and biochemical characteristics of overweight or obese people with severe COVID-19 pneumonia and evaluate its association with mechanical ventilation requirements in a Mexican cohort. Subjects and methods: Data were obtained from medical electronic records. Patients were divided in three groups according to the World Health Organization (WHO) classification of body mass index (BMI): lean, overweight and obese. Baseline characteristics and clinical course were compared among these 3 groups. Results: The study included a total of 355 patients with confirmed COVID-19 diagnoses. Patients with obesity and overweigh, according to the WHO classification, had no significantly increased risk of requiring intubation and invasive mechanical ventilation (IMV) compared to lean subjects, with an odds ratio (OR) of 1.82 (95% CI, 0.94-3.53). A post hoc and multivariate analysis using a BMI > 35 kg/m2 to define obesity revealed that subjects above this cut off had as significantly increased risk of requiring IMV after with an OR of 2.86 (95% CI, 1.09-7.05). Conclusion: We found no higher risk of requiring IMV in patients with overweight or obesity while using conventional BMI cutoffs. According to our sensitivity analyses, the risk of IMV increases in patients with a BMI over 35 kg/m2.

Humans , Respiration, Artificial , COVID-19 , Body Mass Index , Risk Factors , Overweight/complications , SARS-CoV-2 , Obesity/complications
Prensa méd. argent ; 107(3): 162-166, 20210000. tab
Article in English | LILACS, BINACIS | ID: biblio-1361246


Introducción: La osteoartritis es una enfermedad que progresa con el tiempo y culmina en la destrucción de articulaciones y ligaduras. La Investigación Básica de Salud (RISKESDAS) 2013 muestra que East Nusa Tenggara tiene la prevalencia más alta de la enfermedad reumática en Indonesia, alrededor del 33,1%. Método: Esta investigación es un estudio observacional-analítico con un diseño transversal. Esta investigación tiene como objetivo determinar los factores que afectan la osteoartritis de los ancianos en el Centro de Salud Comunitario de Sikumana, distrito de Maulafa, ciudad de Kupang durante el período de diciembre de 2018 a febrero de 2019. Resultado: En esta investigación, índice de masa corporal / IMC (PR = 1,21, p = 0,037) tiene una correlación significativa con la osteoartritis de los ancianos, sin embargo, el género (RP = 1,02, p = 0,839) y los antecedentes de trauma de rodilla (RP = 1,08, p = 0,453) no tienen una correlación significativa con la osteoartritis de los ancianos. Conclusión: un cuerpo con sobrepeso aumenta la presión mecánica de la articulación de la rodilla, lo que provoca la osteoartritis. En esta investigación, las mujeres tienen un mayor riesgo de sufrir osteoartritis en comparación con los hombres. Cuanto mayor sea el IMC, la prevalencia de la osteoartritis aumenta significativamente. Alrededor del 41% de los ancianos con osteoartritis tienen obesidad. Entre otros riesgos, la obesidad muestra una correlación con la prevalencia de osteoartritis. Se debe aumentar la conciencia de los pacientes sobre el índice de masa corporal (IMC) para reducir la prevalencia de la osteoartritis.

Introduction: Osteoarthritis is a disease that progresses over time and culminates in the destruction of articular and joints. Basic Health Research (RISKESDAS) 2013 shows that East Nusa Tenggara have the highest prevalence of the rheumatic disease in Indonesia, about 33,1 %. Method: This research is an observational-analytic study with a cross-sectional design. This research aims to determine the factors affecting Osteoarthritis of the Elderly at Sikumana Community Health Center, Maulafa District, Kupang City during the period of December 2018 to February 2019. Result: In this research, body mass index/BMI (PR=1,21, p=0,037) has a significant correlation to osteoarthritis of the elderly, yet gender (PR=1,02, p=0,839) and history of knee trauma (PR=1,08, p=0,453) have no significant correlation to osteoarthritis of the elderly. Conclusion: An overweight body increases the mechanical pressure of the knee joint, which causes osteoarthritis. In this research, women have a higher risk of osteoarthritis compared to men. The higher the BMI, the prevalence of osteoarthritis increases significantly. Around 41 % of the Elderly with Osteoarthritis have obesity. Amongst any other risks, obesity shows a correlation with the prevalence of Osteoarthritis. Patients' awareness of the body mass index (BMI) should be increased to reduce the prevalence of osteoarthritis.

Humans , Aged , Aged, 80 and over , Osteoarthritis/etiology , Body Mass Index , Cross-Sectional Studies , Osteoarthritis, Knee/complications , Overweight/complications , Age Factors , Obesity
Int. braz. j. urol ; 47(1): 8-19, Jan.-Feb. 2021. tab, graf
Article in English | LILACS | ID: biblio-1134333


ABSTRACT Objective: Recently, several studies have found that obesity had a protective effect against varicocele, but no meta-analysis has confirmed this finding. Therefore, we conducted this meta-analysis to investigate the association between body mass index (BMI) and varicocele. Material and Methods: We searched for studies in PubMed, Science Direct and the Cochrane Library from inception until February 2018. The association between BMI and varicocele was assessed by pooling the odds ratios (ORs). Results: Eleven eligible studies with a total study population of 1.376.658 participants were included in our analysis. According to BMI, the subjects were defined as belonging to the obese, overweight and underweight groups. Our results showed that the obese group had a lower risk of varicocele when compared with the normal weight group (odds ratio [OR] 0.46, 95% confidence intervals [CIs] 0.37-0.58). Additionally, an overweight BMI had a protective effect against varicocele (OR 0.70, 95% CIs, 0.56-0.86). However, underweight patients had a more than 30% higher risk of varicocele (OR 1.31, 95% CI, 1.04-1.64). Furthermore, there was no publication bias in any of the analyses. Conclusions: Our study demonstrates that BMI is negatively associated with the presence of varicocele.

Humans , Male , Varicocele/epidemiology , Body Mass Index , Odds Ratio , Overweight/complications , Overweight/epidemiology , Obesity/complications
Arch. cardiol. Méx ; 90(4): 490-497, Oct.-Dec. 2020. tab, graf
Article in English | LILACS | ID: biblio-1152824


Abstract Background: Overweight and obesity (O/O) generate lipotoxicity of the cardiac fiber and increase the incidence and progression of aortic valve stenosis. The low cardiac output syndrome (LCOS) is a timing complication after to aortic valve replacement (AVR) surgery. Objective: The objective of the study was to investigate if body mass index (BMI) kg/m2 is a risk factor associated with LCOS and mortality in the post-operative period of AVR. Methods: A historic cohort study was designed, including patients with severe aortic stenosis (SAS), who were subjected to AVR. Results: 152 patients were included, 45 (29.6%), with normal weight (NW), 60 were overweight (39.5%), and 47 obese (30.9%). The prevalence of systemic hypertension (HT) was higher in O/O (p < 0.0001). Incidence of LCOS was 44.7%, being more frequent in the O/O groups compared to the NW group, 43.3%, 68.1%, and 22.2%, respectively, (p < 0.05 in overweight and p < 0.0001 in the obese). Assessing the presence or absence of LCOS associated with BMI as a numerical variable, we found that women, HT, BMI, left ventricular mass, and valve size, were associated with LCOS (p < 0.02, p < 0.02, p < 0.001, p < 0.032, and p < 0.045, respectively). Mortality was higher in patients who had LCOS (p < 0.02). Multivariate model showed that BMI was an independent risk factor for LCOS (odds ratio [OR] 1.21 [95% CI 1.08-1.35], p < 0.001). Conclusion: BMI is a risk factor associated to LCOS in the post-operative period of AVR in patients with SAS.

Resumen Antecedentes: El sobrepeso y la obesidad (O/O) generan lipotoxicidad de la fibra cardíaca y aumentan la incidencia y progresión de la estenosis de la válvula aórtica. El síndrome de bajo gasto cardíaco (SBGC) es una complicación postquirúrgica de la cirugía de reemplazo de válvula aórtica (RVA). Objetivo: Investigar si el índice de masa corporal kg/m2 (IMC) es un factor de riesgo asociado con SBGC y mortalidad en el postoperatorio de RVA. Métodos: Se diseñó un estudio de cohorte histórico, que incluyó pacientes con estenosis aórtica importante (EAI), que fueron sometidos a RVA. Resultados: Se incluyeron 152 pacientes, 45 (29.6%), con peso normal (N), 60 tenían sobrepeso (39.5%) y 47 obesos (30.9%). La prevalencia de hipertensión sistémica (HT) fue mayor en O/O (p < 0.0001). La incidencia de SBGC fue del 44.7%, siendo más frecuente en los grupos O/O en comparación con el grupo N, 43.3%, 68.1%, 22.2% respectivamente, (p < 0.05 en sobrepeso y p < 0.0001 en obesos). Al evaluar la presencia o ausencia de SBGC asociado con el IMC como una variable numérica, encontramos que las mujeres, HT, IMC, masa ventricular izquierda y tamaño de la válvula, se asociaron con SBGC (p < 0.02, p < 0.02, p < 0.001, p < 0.032, p < 0.045, respectivamente). La mortalidad fue mayor en pacientes con SBGC (p < 0.02). El modelo multivariado mostró que el IMC fue un factor de riesgo independiente asociado a SBGC [OR 1.21 (IC 95% 1.08-1.35), p < 0.001]. Conclusión: El IMC es un factor de riesgo asociado a SBGC en el postoperatorio de RVA en pacientes con EAI.

Humans , Male , Female , Middle Aged , Aged , Aged, 80 and over , Aortic Valve Stenosis/surgery , Postoperative Complications/epidemiology , Cardiac Output, Low/epidemiology , Heart Valve Prosthesis Implantation/adverse effects , Postoperative Complications/mortality , Cardiac Output, Low/etiology , Cardiac Output, Low/mortality , Body Mass Index , Incidence , Retrospective Studies , Risk Factors , Cohort Studies , Heart Valve Prosthesis Implantation/methods , Overweight/complications , Ideal Body Weight , Obesity/complications
Femina ; 48(10): 623-630, 20201031. ilus
Article in Portuguese | LILACS | ID: biblio-1127709


A contracepção de emergência tem como objetivo prevenir uma gravidez indesejada após uma relação sexual desprotegida, falha do método contraceptivo regular ou agressão sexual. Dentre os métodos disponíveis atualmente, destaca-se a pílula hormonal de levonorgestrel (LNG) como uma das principais estratégias utilizadas, tendo em vista o perfil de segurança desse fármaco e a facilidade de acesso e utilização dele. No entanto, embora o efeito de tal molécula seja satisfatório, pesquisas sugerem que altos índices de massa corporal implicam uma redução da eficácia contraceptiva da pílula de LNG. Nesse sentido, esse estudo visa evidenciar, mediante revisão de literatura, a relação entre esse fármaco e sua competência em mulheres com sobrepeso ou obesidade, bem como expor quais medidas devem ser tomadas para evitar a gravidez indesejada nessas pacientes. Embora existam divergências, foi observado que a maior parte dos estudos indica que a composição corporal das pacientes pode influenciar na eficácia contraceptiva da molécula de LNG, de forma sinérgica ou não com outros fatores, especialmente quando considerado o IMC > 25 kg/m² ou peso > 75 kg, uma vez que o risco de gravidez pode aumentar de 1,5 até 4,4 vezes quando comparado aos padrões de normalidade, com tendência de crescimento em relação aos parâmetros de sobrepeso/obesidade.(AU)

The main goal of the emergency contraceptive is to prevent a non-planned pregnancy after the sexual relationship without condom, after the fail of the usual contraceptive or the sexual assault. Among all the currently available methods, the hormonal pill of levonorgestrel (LNG) has its importance as one of the most used strategies, due of its safety, easy access and use. However, in spite of the fact that this molecule has a good effect, some researches suggest that a high level of the body mass reduces the efficacy of the contraceptive pill of LNG. In this context, this study objective is to clarify, by using literature review, the relation between this drug and its competence in overweight/obese women, as well to expose which other options could be taken to avoid a non-planned pregnancy in those patients. Despite of the fact that there are divergences, the most part of the studies shows that patient's body composition can influence on the contraceptive effectiveness of the LNG molecule, sinergically or not to other factors, especially when the IMC > 25 kg/m² or the body weight > 75 kg, once the pregnancy risk can be raised from 1,5 to 4,4 times when compared to regular standards, with growth tendency when related to overweigh/obesity parameters.(AU)

Humans , Female , Pregnancy , Levonorgestrel/therapeutic use , Levonorgestrel/pharmacokinetics , Contraceptives, Postcoital/therapeutic use , Overweight/complications , Obesity/complications , Databases, Bibliographic , Contraception/adverse effects
Rev. Col. méd. cir ; 159(1): 26-30, abr 2020. tab
Article in Spanish | LILACS, LIGCSA | ID: biblio-1247559


Objetivo: describir el riesgo cardiovascular de pacientes con diabetes mellitus tipo 2 (DM2), según los valores de proteína C reactiva ultrasensible (PCR-us). Material y métodos: estudio descriptivo transversal, realizado en el Patronato del Diabético de zona 1, Ciudad de Guatemala, en el cual participaron 196 pacientes mayores de 50 años de edad, obteniéndose características sociodemográficas, medidas antropométricas. Además, se tomaron muestras de sangre que fueron procesadas en iCroma ll para determinar los valores de Proteína C reactiva ultrasensible (PCR-us). Resultados: los pacientes que aceptaron formar parte del estudio, tuvieron una media de edad de 62±8.62 DE; 74.4% (146) fueron del sexo femenino; 54% (106) eran católicos y el 82.1% (161), residían en la Ciudad de Guatemala. El estado nutricional fue normal en el 26% (50), el 11% (21) tenía sobrepeso y 63% (125), obesidad. Para índice cintura cadera (ICC) con respecto al sexo femenino, se obtuvo una media de 0.89±0.05 DE y una media 0.97±0.05 DE del sexo masculino. Respecto al riesgo cardiovascular, se obtuvo una media en valores de PCR-us de 2.9±2.8 DE, con 76% (148) de los pacientes en riesgo cardiovascular moderado/alto. Conclusiones: los valores de PCR-us tuvieron una media de 2.9±2.8 DE y 8 de cada 10 pacientes están en riesgo moderado/alto. De los pacientes estudiados, 7 de cada 10 fueron mujeres, con una media para a edad de 62 años. Se encontraron 7 de cada 10 con sobrepeso u obesidad, con una media para índice cintura cadera con respecto al sexo elevado.

Objective: to describe the cardiovascular risk of patients with type 2 diabetes mellitus, according to the values of ultrasensitive C-reactive protein (PCR-us). Material and methods: descriptive cross-sectional study, carried out on 196 patients over 50 years of age, from the Diabetic Board of Trustees in Zone 1, Guatemala. Data on sociodemographic characteristics, anthropometric measurements and blood were obtained. The blood samples were processed in iCroma ll to determine the values of ultrasensitive reactive Protein C (PCR-us). Results: the patients who accepted to be part of the study had a mean age of 62 ± 8.62 SD years; 74.4% (146) were female; 54% (106) were catholic, and 82.1% (161) resided in Guatemala City. Nutritional status was normal in 50 patients (26%), 21, overweight (11%) and 125, obese (63%). For the waisthip index, with respect to the female, an average of 0.89 ± 0.05 SD and for males, an average 0.97 ± 0.05 SD were obtained. Regarding cardiovascular risk, an average in PCR-us values of 2.9 ± 2.8 SD was obtained; 76% (148) of patient were at moderate / high cardiovascular risk.

Humans , Male , Female , Middle Aged , Aged , C-Reactive Protein/analysis , Cardiovascular Diseases/blood , Diabetes Mellitus, Type 2/blood , Biomarkers , Cardiovascular Diseases/etiology , Cardiovascular Diseases/prevention & control , Nutritional Status , Cross-Sectional Studies , Risk Factors , Diabetes Mellitus, Type 2/complications , Overweight/complications , Social Factors , Obesity/complications
Rev. Assoc. Med. Bras. (1992) ; 66(3): 300-306, Mar. 2020. tab, graf
Article in English | LILACS, SES-SP | ID: biblio-1136211


SUMMARY OBJECTIVES To compare the serum concentrations of adipokines resistin and chemerin in children and adolescents with eutrophic and overweight and to evaluate their relationship with anthropometric, biochemical, and blood pressure variables. METHODS a cross-sectional epidemiological study was conducted with 234 students enrolled in public elementary schools in the city of Juiz de Fora / MG. Anthropometric evaluation, biochemistry, and blood pressure measurement were performed. Statistical analyzes included the Student-t or Mann-Whitney tests, Pearson or Spearman correlation, used according to the distribution of the variables, and linear regression analysis, by means of the evaluation of the effect of the independent variables on the serum levels of chemerin and resistin, adjusted for age and sex. For the data analysis, SPSS® software version 21.0 and STATA® version 10.1 were used, assuming a significance level of 5%. RESULTS the concentrations of chemerin were higher in eutrophic individuals than in those with excess weight (p> 0.05). In contrast, levels of resistin were higher in the young with excess weight than in the eutrophic ones (p <0.05). In the multiple linear regression analysis, the levels of chemerin were associated with the values of resistin, systolic, and diastolic blood pressure. Resistance levels maintained association only with BMI and chemerin values. CONCLUSION the adipokines analyzed presented a distinct profile in the groups of children and adolescents with eutrophic and overweight.

RESUMO OBJETIVOS Comparar as concentrações séricas das adipocinas resistina e quemerina em crianças e adolescentes com eutrofia e excesso de peso e avaliar sua relação com as variáveis antropométricas, bioquímicas e a pressão arterial. MÉTODOS Estudo epidemiológico transversal realizado com 234 estudantes matriculados em escolas públicas do ensino fundamental no município de Juiz de Fora/MG. Realizou-se avaliação antropométrica, bioquímica e aferição da pressão arterial. As análises estatísticas compreenderam os testes t de Student ou Mann-Whitney, correlação de Pearson ou Spearman, utilizados de acordo com a distribuição das variáveis, e análise de regressão linear, realizada por meio da avaliação do efeito das variáveis independentes nos níveis séricos de quemerina e resistina, ajustado por idade e sexo. Para a análise dos dados foram utilizados os softwares SPSS® versão 21.0 e Stata® versão 10.1, admitindo-se nível de significância de 5%. RESULTADOS As concentrações de quemerina foram maiores nos indivíduos eutróficos do que nos com excesso de peso (p>0,05). Em contrapartida, os níveis de resistina estiveram maiores nos jovens com excesso ponderal do que nos eutróficos (p<0,05). Na análise de regressão linear múltipla, os níveis de quemerina apresentaram associação com os valores de resistina, pressão arterial sistólica e diastólica. Os níveis de resistina mantiveram associação apenas com os valores de IMC e quemerina. CONCLUSÃO As adipocinas analisadas apresentaram perfil distinto nos grupos de crianças e adolescentes com eutrofia e com excesso de peso.

Humans , Male , Female , Child , Adolescent , Chemokines/blood , Overweight/blood , Adiponectin/blood , Resistin/blood , Anthropometry , Cross-Sectional Studies , Intercellular Signaling Peptides and Proteins , Overweight/complications , Overweight/metabolism , Adipokines
Einstein (Säo Paulo) ; 18: eAO5075, 2020. tab
Article in English | LILACS | ID: biblio-1101100


ABSTRACT Objective To evaluate the nutritional risk factors in patients eligible for hematopoietic stem cell transplantation. Methods A cross-sectional, descriptive study conducted with patients recruited from an hematology outpatient clinic. Study variables included demographic and clinical data, patient-generated global subjective assessment findings, anthropometric indicators, food intake and oxidative stress levels. The level of significance was set at 5% (p<0.05). Results The sample comprised 72 patients, mean age of 48.93 years (14.5%). Multiple myeloma was the most prevalent condition (51.4%) in this sample. Most patients (55.6%) were overweight according to body mass index and at risk of cardiovascular disease according to waist circumference, conicity index and percentage of body fat. Sarcopenia was associated with risk of cardiovascular disease, hip-to-waist ratio (p=0.021), muscle strength depletion (p<0.001), food intake (p=0.023), reduced functional capacity (p=0.048), self-reported well-nourished status; p=0.044) and inadequate vitamin B6 (p=0.022) and manganese (p=0.026) intake. Elevated oxidative stress, detected in 33.3% of patients in this sample, was not associated with sarcopenia. Conclusion Most patients in this sample were overweight and sarcopenic. Lean mass depletion was associated with risk of cardiovascular disease, reduced muscle strength, food intake changes, reduced functional capacity, self-reported well-nourished status and inadequate intake of vitamin B6 and manganese, but not with oxidative stress.

RESUMO Objetivo Avaliar os fatores de riscos nutricionais em pacientes pré-transplante de célula-tronco hematopoiética. Métodos Estudo transversal, descritivo, realizado com pacientes de um ambulatório de hematologia. As variáveis estudadas foram demográficas, dados clínicos, avaliação subjetiva global produzida pelo próprio paciente, indicadores antropométricos, ingestão alimentar e estresse oxidativo. Os dados foram considerados estatisticamente significativos quando p<0,05. Resultados A amostra do estudo foi constituída por 72 pacientes, com média de idade de 48,93 (14,5%) anos e com mieloma múltiplo (51,4%) como a patologia mais prevalente. Conforme índice de massa corporal, 55,6% dos pacientes encontravam-se com excesso de peso. De acordo com a circunferência da cintura, índice de conicidade e percentual de gordura corporal, houve prevalência de risco para doença cardiovascular. A sarcopenia foi associada ao risco de doença cardiovascular pela relação cintura/quadril (p=0,021), depleção da força muscular (p<0,001), além da ingestão alimentar (p=0,023), da capacidade funcional reduzida (p=0,048) e do diagnóstico de "bem nutrido" (p=0,044), conforme a avaliação subjetiva global, e com consumo inadequado de vitamina B6 (p=0,022) e de manganês (p=0,026). Dentre os avaliados, 33,3% apresentaram estresse oxidativo elevado sem associação com sarcopenia. Conclusão Pacientes do pré-transplante se apresentam, em sua maioria, com excesso de peso, mas com sarcopenia, estando essa ausência de massa magra associada a risco de doença cardiovascular, depleção da força muscular, alteração da ingestão alimentar, redução da capacidade funcional, classificação de "bem nutrido", segundo a avaliação subjetiva global e consumo inadequado de vitamina B6 e manganês, não estando associada a estresse oxidativo.

Humans , Male , Female , Adult , Nutrition Assessment , Risk Assessment/methods , Hematopoietic Stem Cell Transplantation/adverse effects , Energy Intake/physiology , Cardiovascular Diseases/etiology , Cardiovascular Diseases/physiopathology , Anthropometry , Nutritional Status/physiology , Cross-Sectional Studies , Risk Factors , Oxidative Stress/physiology , Eating/physiology , Overweight/complications , Overweight/physiopathology , Muscle Strength/physiology , Sarcopenia/complications , Sarcopenia/physiopathology , Middle Aged , Multiple Myeloma/surgery , Multiple Myeloma/physiopathology
Rev Rene (Online) ; 21: 42272, 2020.
Article in English, Portuguese | LILACS, BDENF | ID: biblio-1053529


Objetivo: avaliar a associação dos fatores de risco com os níveis pressóricos elevados em universitários. Métodos: estudo descritivo, transversal, desenvolvido com 203 universitários, por meio de questionário autoaplicável, construído com base no instrumento para Vigilância de Fatores de Risco e Proteção Para Doenças Crônicas por Inquérito Telefônico do Ministério da Saúde. A análise dos dados foi realizada pelo teste Tau de Kendall. Resultados: dos participantes do estudo, 164 (80,8%) possuíam níveis pressóricos referentes à pressão arterial normal, nove (4,4%) pré-hipertensão, 30 (14,8%) hipertensão. Quanto ao estilo de vida, 16 (7,9%) eram fumantes, 12 (5,9%) faziam uso abusivo de álcool, 137 (67,5%) eram ativos, 64 (31,5%) possuíam adiposidade abdominal, 29 (14,3%) estavam com sobrepeso ou obesidade e 32 (15,8%) faziam uso excessivo de sal. Conclusão: os fatores de risco relacionados aos níveis pressóricos elevados foram: ter 35 anos ou mais de idade, adiposidade abdominal, sobrepeso ou obesidade. (AU)

Humans , Male , Female , Adult , Students , Hypertension/etiology , Cross-Sectional Studies , Risk Factors , Age Factors , Overweight/complications , Life Style
Rev. Paul. Pediatr. (Ed. Port., Online) ; 38: e2019080, 2020. tab, graf
Article in English | LILACS | ID: biblio-1092141


ABSTRACT Objective: To evaluate the nutritional status and gastrointestinal changes in children with autism spectrum disorder (ASD). Methods: Cross-sectional, descriptive analysis of 39 children with ASD aged between three and ten years old, registered in the participating association. Nutritional status was evaluated by body mass index/age and weight/age, according to the guidelines from the World Health Organization. In order to investigate whether gastrointestinal alterations occurred, the interviewees answered a questionnaire about the presence of these symptoms within the last 30 days. In order to evaluate food consumption, a 24-hour recall questionnaire was applied and the food reported were grouped as: gluten sources, casein and ultra-processed sources. For the statistical analysis, Epi-Info software version 7.2 was used. Multivariate logistic regression analysis was performed to evaluate the variables associated with gastrointestinal alterations. Results: There was a high prevalence of overweight children with autism spectrum disorder (64.1%). No child was underweight. Thirty-four children (84.2%) had gastrointestinal symptoms. Consumption of gluten was associated with gastrointestinal symptoms (β=0.38; 95%CI 0.07-0.75; p=0.02). Conclusions: The high prevalence of being overweight should be considered during the follow-up visits of children with ASD. The influence of gluten consumption on the presence of gastrointestinal symptoms was observed in this study, and the causes involved in these alterations need to be further investigated.

RESUMO Objetivo: Avaliar o estado nutricional e a presença de alterações gastrintestinais em crianças com transtorno do espectro autista. Métodos: Estudo transversal, descritivo, composto por 39 crianças autistas com idades entre três e dez anos, cadastradas na associação participante. O estado nutricional foi analisado a partir do índice de massa corporal/idade e do peso/idade, tendo como referências as curvas da Organização Mundial da Saúde. Para investigação das alterações gastrintestinais, o entrevistado respondeu sobre a presença de alterações nos últimos 30 dias. Na avaliação do consumo alimentar foi aplicado um recordatório de 24 horas e os alimentos listados foram categorizados em: fontes de glúten, fontes de caseína e ultraprocessados. A análise estatística utilizou o software Epi-Info, versão 7.2. Foi realizada a análise de regressão logística multivariada para avaliar os fatores associados às alterações gastrintestinais. Resultados: Observou-se alta prevalência de excesso de peso nas crianças com transtorno do espectro autista (64,1%), não sendo registrada nenhuma criança com déficit de peso. Um total de 34 crianças (84,2%) apresentava alterações gastrintestinais. O consumo de glúten esteve associado às manifestações gastrintestinais (β=0,38; IC95% 0,07-0,75; p=0,02). Conclusões: A elevada prevalência do excesso de peso deve ser tratada com maior atenção em crianças com transtorno do espectro autista. Foi observada a influência do consumo de glúten no aparecimento das alterações gastrintestinais, sendo necessário que as causas envolvidas nessas alterações sejam mais bem investigadas.

Humans , Male , Female , Child, Preschool , Child , Nutritional Status , Overweight/complications , Autism Spectrum Disorder/complications , Gastrointestinal Diseases/complications , Body Mass Index , Diet Records , Cross-Sectional Studies , Surveys and Questionnaires , Glutens/administration & dosage , Glutens/adverse effects
Int. braz. j. urol ; 45(4): 790-797, July-Aug. 2019. tab
Article in English | LILACS | ID: biblio-1019876


ABSTRACT Objective The purpose of this study was to determine whether the presence of obesity was related with symptoms of nocturnal enuresis (NE) and the efficacy of behavioral intervention in the treatment of NE. Materials and Method The patients diagnosed with primary monosymptomatic nocturnal enuresis (PMNE) were studied retrospectively. NE severity was classified as mild, moderate, and severe according to the frequency of enuresis. The children were divided into three groups, namely normal weight (5th-84th percentile), overweight (85th-94th percentile), and obesity (≥95th percentile), according to their Body Mass Index (BMI) percentage. The relationship between obesity level and enuresis severity was analyzed. After three months of behavioral therapy, the efficacy of treatment among normal, overweight, and obese groups were evaluated. Moreover, the predictive risk factors for treatment failure were investigated. Results The rates of severe enuresis in patients with normal weight, overweight, and obesity were 63.9%, 77.5%, and 78.6%, respectively. Obese children depicted higher odds of having severe enuresis compared with normal-weight children (OR: 1.571; 95% confidence interval [CI]: 1.196-2.065; P=0.001). The odds of presenting with severe enuresis were 1.99 times higher in children who are obese or overweight compared to children with normal weight (OR: 1.994; 95% CI: 1.349-2.946; P=0.001). The complete response of the normal group was higher than those of the overweight and obese groups (26.8% vs. 14.0%, P=0.010; 26.8% vs. 0.0%, P=0.000). Overweight children showed higher complete response than obese ones (14.0% vs. 0.0%, P=0.009). Logistic regression analysis revealed that obesity level and enuresis frequency were significantly related to the treatment failure of behavioral intervention. Conclusions Obesity is associated with severe enuresis and low efficacy of behavioral therapy in children with nocturnal enuresis.

Humans , Male , Female , Child, Preschool , Child , Adolescent , Behavior Therapy/methods , Nocturnal Enuresis/etiology , Nocturnal Enuresis/therapy , Pediatric Obesity/complications , Reference Values , Severity of Illness Index , Body Mass Index , Logistic Models , Sex Factors , Retrospective Studies , Risk Factors , Treatment Failure , Overweight/complications
Rev. Bras. Saúde Mater. Infant. (Online) ; 19(2): 275-283, Apr.-June 2019. tab
Article in English | LILACS | ID: biblio-1013141


Abstract Objectives: to investigate the relationship between the Diet Quality Index Adapted for Pregnant Women (IQDAG) and excess maternal body weight. Methods: a cross-sectional study was conducted with 754 adult pregnant women, in Ribeirão Preto, São Paulo, between 2011 and 2012. The criteria proposed by Atalah were used to classify the body mass index (BMI). Adjusted multinomial logistic regression models were employed to investigate the relationship between the IQDAG and being overweight and obese, estimating the odds ratio (OR) and the 95% confidence interval (CI95%). Results: the mean (SD) age of women was 28 (5) years, 33.4% were overweight and 25.6% obese. The pregnant women with higher scores in the IQDAG were less likely to be overweight [OR= 0.56 (CI95% = 0.37-0.85)] or obese [0.43 (0.26-0.71)]; those with higher scores in the "Fiber" [0.51 (0.33; 0.78)] and "Iron" [0.62 (0.40-0.96)] components were less likely to be overweight. However, women with higher scores in the percentage of energy from ultra-processed foods were more likely to be overweight [1.72 (1.10-2.94)] or obese [5.24 (2.80-9.80)], when compared to women with lower scores. Conclusions: poorer quality maternal diets were observed among the women who were overweight and obese during pregnancy.

Resumo Objetivos: investigar a relação entre o Índice de Qualidade da Dieta Adaptado para Gestantes (IQDAG) e o excesso de peso materno. Métodos: estudo transversal conduzido entre 754 gestantes adultas em Ribeirão Preto, SP, entre 2011 e 2012. Os critérios propostos por Atalah foram empregados para a classificação do índice de massa corporal (IMC). Modelos de regressão logística multinomial ajustados foram utilizados para investigar a relação da pontuação do IQDAG com o sobrepeso e obesidade, estimando-se o odds ratio (OR) e seu intervalo de confiança de 95% (IC95%). Resultados: a média (DP) de idade das mulheres foi de 28 (5) anos, 33,4% e 25,6% eram portadoras de sobrepeso e obesidade, respectivamente. As gestantes com maior pontuação do IQDAG apresentaram menor chance de sobrepeso [OR= 0,56 (IC95%= 0,37-0,85)] e obesidade [0,43 (0,26-0,71)]; as com maior pontuação para os componentes "Fibras" [0,51 (0,33-0,78)] e "Ferro" [0,62 (0,40-0,96)] apresentaram menor chance de sobrepeso. Em contrapartida, mulheres com maior pontuação para o percentual do valor energético proveniente dos alimentos ultraprocessados apresentaram maior chance de sobrepeso [1,72 (1,10-2,94)] e obesidade [5,24 (2,80-9,80)], quando comparadas com as mulheres com menor pontuação. Conclusões: pior qualidade da dieta materna foi observada entre as mulheres portadoras de sobrepeso e obesidade no período gestacional.

Humans , Female , Pregnancy , Nutrition Surveys , Overweight/complications , Maternal Nutrition , Brazil , Body Mass Index , Maternal and Child Health , Industrialized Foods , Obesity/complications
Gac. méd. Méx ; 155(3): 236-242, may.-jun. 2019. tab
Article in English, Spanish | LILACS | ID: biblio-1286498


Resumen Introducción: La hiperuricemia es un factor de riesgo para enfermedad cardiovascular, pero su impacto no ha sido bien documentado. Objetivo: Evaluar el impacto de la hiperuricemia en los parámetros metabólicos y los factores de riesgo cardiovascular en mexicanos aparentemente sanos. Método: Estudio trasversal de 768 adultos jóvenes. Se buscó asociación de la hiperuricemia con alteraciones de los parámetros metabólicos y factores de riesgo cardiovascular (hipertensión, dislipidemia mixta y síndrome metabólico). Se aplicaron modelos loglineales y de regresión para determinar la influencia de la hiperuricemia. Se aplicó análisis multivariado de varianza para observar la interacción de la hiperuricemia y el sobrepeso u obesidad en los cambios de los parámetros metabólicos. Resultados: Los parámetros metabólicos fueron mayores en los individuos con hiperuricemia que con ácido úrico normal (< 0.05). La hiperuricemia se asoció significativamente con hipertensión (RM = 6.8, IC 95 % = 1.1-46), dislipidemia (RM = 2.5, IC 95 % = 1.3-4.7) y síndrome metabólico (RM = 2.3, IC 95 % = 1.1-4.6). La hiperuricemia y el sobrepeso u obesidad predicen significativamente los cambios en los parámetros metabólicos de riesgo cardiovascular (l de Wilks = 0.91, F [6.175] = 3.1, p = 0.007). Conclusiones: La hiperuricemia está asociada significativamente con las alteraciones metabólicas y los distintos factores de riesgo cardiovascular.

Abstract Introduction: Hyperuricemia is a risk factor for cardiovascular disease, but its impact has not been properly documented. Objective: To assess the impact of hyperuricemia on metabolic parameters and cardiovascular risk factors (CRF) in apparently healthy Mexicans. Method: Cross-sectional study of 768 young adults. Association of hyperuricemia with alterations in metabolic parameters and CRF (hypertension, mixed dyslipidemia, metabolic syndrome) was sought. Log-linear and regression models were used to determine the influence of hyperuricemia. A multivariate analysis of variance was applied to observe the interaction of hyperuricemia and overweight or obesity with changes in metabolic parameters. Results: Metabolic parameters were higher in patients with hyperuricemia than with normal uric acid (all < 0.05). Hyperuricemia was significantly associated with hypertension (OR=6.8, 95 % CI: 1.1-46), dyslipidemia (OR=2.5, 95% CI: 1.3-4.7) and metabolic syndrome (OR=2.3, 95% CI: 1.1-4.6). Hyperuricemia and overweight or obesity significantly predict changes in cardiovascular risk metabolic parameters (Wilks’ l=0.91, F (6.175)=3.1, p=0.007). Conclusions: Hyperuricemia is significantly associated with metabolic alterations and different CRF.

Humans , Male , Female , Adolescent , Young Adult , Cardiovascular Diseases/etiology , Metabolic Syndrome/epidemiology , Hyperuricemia/complications , Dyslipidemias/epidemiology , Hypertension/epidemiology , Cardiovascular Diseases/epidemiology , Cross-Sectional Studies , Risk Factors , Overweight/complications , Mexico/epidemiology , Obesity/complications
Rev. Soc. Cardiol. Estado de Säo Paulo ; 29(2): 148-154, abr.-jun. 2019. graf
Article in English, Portuguese | LILACS | ID: biblio-1009485


As doenças cardiovasculares continuam sendo a principal causa de morte no Brasil desde o final da década de 1960, a despeito da tendência de queda observada nos últimos anos. A mudança de estilo de vida relacionada à urbanização e globalização, com alta ingestão calórica e menor gasto energético, o rápido aumento da população idosa devido à maior expectativa de vida levaram à maior prevalência de obesidade e dislipidemias e, consequentemente, doenças cardiovasculares e metabólicas. Pesquisas de base populacional, estudos de coorte e de caso e de controle apontam para a importância do crescimento dos fatores de risco e diferenças regionais indicam que as políticas públicas e o atendimento médico devem priorizar intervenções de saúde tendo como objetivo a prevenção e controle dos fatores de risco mais prevalentes em nosso meio. A abordagem terapêutica da obesidade deve incluir não apenas a redução isolada do peso, e sim, atrelada à melhora metabólica ampla que se associe à diminuição do risco de complicações cardiovasculares. De um modo geral, a perda de peso é mais frequentemente alcançada ao longo dos primeiros meses ou do primeiro ano de exposição aos fármacos e embora alguns sejam mais efetivos, eventos adversos são frequentes, limitando o tratamento a longo prazo. O grande avanço e a maior segurança nos últimos anos vieram com o uso de medicamentos antiiperglicemiantes, como análogos de GLP-1, permitindo o uso a longo prazo com manutenção de resultados e adicionando benefícios cardiovasculares. A abordagem terapêutica das dislipidemias no paciente obeso é imperativa para a evolução desse perfil de pacientes, nos quais múltiplos fatores fisiológicos, bioquímicos, metabólicos e clínicos, estão interconectados e diretamente relacionados com aumentos substanciais do risco de diabetes, de doença aterosclerótica cardiovascular e mortalidade por todas as causas

Cardiovascular disease has been the no. 1 cause of death in Brazil since the late 1960s, despite the downtrend observed in recent years. Lifestyle changes related to urbanization and globalization, high calorie intake and lower energy expenditure, combined with a rapidly aging population due to increased life expectancy, have led to a greater prevalence of obesity and dyslipidemia, and consequently, cardiovascular and metabolic diseases. Population-based surveys, cohort and case-control studies underline the importance of the growth of risk factors, and regional differences indicate that public policies and medical care must prioritize health interventions in order to prevent and control the most prevalent risk factors in our country. The therapeutic approach to obesity must include not only weight reduction alone, but also in combination with comprehensive metabolic improvement, which is associated with a reduced risk of cardiovascular complications. In general, weight loss is more frequently achieved in the first few months or first year of exposure to medications, and although some drugs are more effective, adverse events are common, limiting treatment options to long-term therapy. The major advances and greater safety seen in recent years were achieved with the use of anti-hyperglycemic agents such as GLP-1 analogues, enabling long-term use with maintenance of results and adding cardiovascular benefits. The therapeutic approach to dyslipidemia in obese patients is imperative for the progress of this patient population, in which multiple physiological, biochemical, metabolic and clinical factors are interlinked and directly related to substantial increases in the risk of diabetes, atherosclerotic cardiovascular disease, and all-cause mortality

Humans , Male , Female , Diet , Dyslipidemias/therapy , Obesity/prevention & control , Obesity/therapy , Time Factors , Brazil , Cardiovascular Diseases/mortality , Body Mass Index , Epidemiology , Prevalence , Risk Factors , Atherosclerosis , Overweight/complications , Life Style
Rev. cuba. pediatr ; 91(1): e729, ene.-mar. 2019.
Article in Spanish | LILACS | ID: biblio-985596


RESUMEN Introducción: La obesidad es un problema de salud mundial y su frecuencia se está incrementando tanto en adultos como en niños. Una de sus complicaciones es la glomerulopatía asociada a la obesidad. Objetivo: Informar acerca de esta enfermedad y la actitud del pediatra para tratar de evitarla. Métodos: Revisión de la literatura médica más reciente sobre la enfermedad y el incremento de la obesidad en la edad pediátrica en las bases de datos PubMed, SciELO y LILACS. Se utilizaron las palabras clave: glomerulopatía relacionada con la obesidad, obesidad y sobrepeso en el niño, tratamiento de la obesidad. Resultados: La obesidad en el niño es en alto porcentaje de causa nutricional y en esta condición los factores ambientales y socioculturales juegan importante papel. La predisposición a padecer la glomerulopatía de la obesidad comienza desde la niñez. El tratamiento de los pediatras en estos casos estará dirigido a la prevención de la enfermedad puesto que se puede desarrollar en la adultez. Cuando fracasan las medidas preventivas, queda la posibilidad de la cirugía bariátrica con poca experiencia en la edad pediátrica y retos éticos importantes y a pesar de que pudiera ser una alternativa de tratamiento, no es aceptada hasta el presente en forma amplia. Conclusiones: La glomerulopatía de la obesidad, por lo general, no aparece hasta la adultez, pero es necesario prevenirla desde la edad pediátrica y para su prevención los pediatras deben estar atentos a los factores de riesgo que pueden aparecer desde las primeras etapas de la vida(AU)

ABSTRACT Introduction: Obesity is a global health problem and its frequency is increasing as much as in adults than in children. One of its complications is glomerulopathy associated to obesity. Objective: To inform on this disease and the attitude of pediatricians towards this trying to avoid it. Methods: Reviewing of the most recent medical literature on this disease and the increase of obesity in the pediatric age in PubMed, SCIELO and LILACS databases. The keywords used for the search were: glomerulopathy related to obesity, obesity and overweight in children, and obesity treatment. Results: Obesity in children is in a high percentage due to nutritional causes and in this disease environmental and sociocultural factors play an important role. The predisposition to suffer from glomerulopathy by obesity starts in childhood. The treatment prepared by the pediatricians in these cases will be directed to the prevention of the disease because it can be developed in adulthood. When preventive measures fail, there is the possibility of performing a bariatric surgery, having in this regard few experiences in the pediatric ages and important ethical challenges; and instead of being an alternative treatment, it is not widely accepted. Conclusions: Generally, glomerulopathy of obesity doesn't appear until adulthood, but it is necessary to prevent it since the pediatric age; and for its prevention pediatricians must be attentive to the risk factors that can appear from the earliest stages of life(AU)

Humans , Male , Female , Child, Preschool , Child , Adolescent , Glomerulosclerosis, Focal Segmental/complications , Pediatric Obesity/complications , Nephrosis, Lipoid/complications , Glomerulonephritis, Membranous/prevention & control , Overweight/complications , Pediatric Obesity/epidemiology