Captopril failed to attenuate the vascular response in type 2 diabetes with microalbuminuria

This study is designed to study the effect if captopril on forearm blood flow aiming to understanding the mechanism of vascular response in type 2 diabetics with microalbuminuria. Department of pharmacology, College of Medicine, Al-Mustansiriyah University, Baghdad- Iraq Design; Arandomized Controlled-Clinical Trial. -24Hour Uriary Albumin Excretion -Echocardiogarphic Study -Doppler Ultrasonographic Study of Brachial Artery. The Initil echocardiographic data of diabetics with regarding the left ventricular dimensions. Single dose of nitroglycerin alttreed theleft ventricular dimension of controls but not the diabetics. Captopril of 12.5 mg/day for 7 days resulted in a significant effect on the aortic root dimension in controls but not in diabetics. Doppler study revealed that reactive hyperemia produced a significant improvement in brachial blood flow in controls rather than in diabetics in term of mean velocity. Nitroglycerin improved the blood flow in diabetics by 11.7% increment of mean velocity Vs 3.4% in controls, while captopril failed to show this effect [7.0% Vs 1.7% increment in controls and diabetics respectively]. The vascular response in type 2 diabetes mellitus with microalbuminuria was influenced by dysfunction rather than the structure of blood vessels by the evidence of effect of nitroglycerin and not captopril

Ciprofloxacin ear drop for active chronic suppurative otitis media; It is safe and effective

This study was designed to show the efficacy of Ciprofloxacin ear drop in 30 patints [40 ears] with active chronic suppurative otitis media [CSOM]. It was performed at Al-Rasheed Military Hospital, Baghdad, Iraq [between may-2001 and jun-2002]. The study was a pilot, observational screening study. Measurements performed included clinical assessment [healing rate and adverse effects] and culture and sensitivity of ear discharge. Results have shown that ciprofloxacin ear-drop was found effective in reducing the otorrhea and making the discharge aseptic. This effect seems to be dose dependant since it is more pronounced and rapid at the higher dose. The success rates after 8 days were 93.3% and 60% for 0.5% and 0.25% of Ciprofloxacin concentration respectively. No important adverse effects were reported during the course of treatment. In addition there were no signe of local intolerance or ototoxicity during the period of drug administration. Ciprofloxacin ear-drop appeared to be safe and effective in treating active CSOM

Hyperhomocysteinemia as an independent risk factor for coronary artery disease

We examined whether hyperhomocysteinemia is an independent risk factor for the development of coronary artery disease [CAD] in randomly selected 25 male patients who have angiographically proved CAD and without any of classical cardiovascular risk factors. And 20 male healthy volunteers are enrolled in this study. The outcome measures include; coronary angiography, ECG, SBp, DBp, FBS, Fasting plasma total Homocysteine [tHcy], Lipid profile, and anthropometric measures. The results showed that all patients and volunteers were below 45 years age, no one of the patients had obesity, hypertension, diabetes mellitus, dyslipidemia or smoking habit. The results: there were no significant difference between patients and controls regarding age, BMI, WHR, SBp, DBp, FBS, and Lipid profile [P>0.05]. While there were a significant higher levels in fasting plasma tHcy in patients compared to that of controls [P< 0.05]. Our results indicate that fasting plasma tHcy levels may act as an independent risk factor for development of CAD, and this result may open anew line of treatment of cardiovascular disease by using drugs that affect the levels of plasma homocystein